Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Wallis, Amy; Jackson, Melinda L.; Ball, Michelle; Lewis, Donald P.; Bruck, Dorothy

doi:10.1002/9781118993811.ch31

Cited by 3 publications

(3 citation statements)

References 118 publications

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“…Studies suggest that the deficits of "inhibitory control" may cause loss of focus, decrease in efficiency, and other attention-related dysfunctions. 8,9 There are several techniques for recovery from attention fatigue that have been investigated, i.e., rest allowances, 10 sleep, 11 mindfulness, yoga-based therapies, 12 and nature experience (NE). 13 Recently, there has been a growing interest to investigate the beneficial effects of brief interactions with natural environment on attention restoration.…”

Section: Introductionmentioning

confidence: 99%

Effect of Nature Experience on Fronto-Parietal Correlates of Neurocognitive Processes Involved in Directed Attention: An ERP Study

Sahni

Kumar

2020

Annals of Neurosciences

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Background: Several studies have demonstrated that brief interactions with natural environments can improve cognitive functioning. However, the neurocognitive processes that are affected by natural surroundings are not yet fully understood. It is argued that the “elements” in natural environment evoke “effortless” involuntary attention and may affect the neural mechanisms underlying inhibition control central to directed attention. Methods: The present study used electroencephalography (EEG) to investigate the effects of nature experience on neurocognitive processes involved in directed attention. During EEG recordings, participants ( n = 53) were presented nature audio/video as stimuli to evoke nature experience, and flanker task was administered both before and after nature experience. An open eye rest condition was included randomly in either before or after nature experience cognitive task as a control condition. Results: The event-related potential analysis demonstrated a significant improvement in the response time after the nature experience. The analysis also demonstrated a significant difference for the inhibitory control process in fronto-parietal N2 ( P < .01) and P3 ( P < .05) for incongruent trials subsequent to nature experience. The spectral analysis also found an increase in alpha in all five brain regions (all Ps < .01) and fronto-central theta power ( P < .01). Conclusion: The findings suggest that improved inhibitory control processes could be one of the aspects of enhanced directed attention after nature experience. Increased alpha along with theta indicates a relaxed yet alert state of mind after nature experience.

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Section: Introductionmentioning

confidence: 99%

Effect of Nature Experience on Fronto-Parietal Correlates of Neurocognitive Processes Involved in Directed Attention: An ERP Study

Sahni

Kumar

2020

Annals of Neurosciences

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“…We acknowledge the complexity and heterogeneity of ME/CFS. Explanation of other pathophysiological mechanisms in ME/CFS (including but not limited to neuro-immune, oxidative stress and inflammatory pathways, [ 116 , 147 , 153 , 155 , 156 ] was beyond the scope of the current review. We stress that d -lactate theory may be relevant for a select subgroup and if not causative, may be a factor that perpetuates or exacerbates neurological symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the impact of nutritional deficiencies in d -la, this may interact with the symptom presentation in ME/CFS and the potential for excess d -lactate accumulation or issues with metabolism. Nutritional deficiencies in ME/CFS may have varied origins, including but not limited to, genetic vulnerabilities, stress, infection, inadequate dietary sources and/or impaired metabolism that are factors involved in the etiology of ME/CFS [ 153 ]. Dietary modifications appear helpful for some ME/CFS patients (self-report in [ 154 ]) and in clinical case reports [ 148 ].…”

Section: Part B Narrative Reviewmentioning

confidence: 99%

Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lactic acidosis: a systematic review

et al. 2017

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BackgroundThe pursuit for clarity in diagnostic and treatment pathways for the complex, chronic condition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continues. This systematic review raises a novel question to explore possible overlapping aetiology in two distinct conditions. Similar neurocognitive symptoms and evidence of d-lactate producing bacteria in ME/CFS raise questions about shared mechanisms with the acute condition of d-lactic acidosis (d-la).Methods d-la case reports published between 1965 and March 2016 were reviewed for episodes describing both neurological symptoms and high d-lactate levels. Fifty-nine d-la episodes were included in the qualitative synthesis comparing d-la symptoms with ME/CFS diagnostic criteria. A narrative review of d-la mechanisms and relevance for ME/CFS was provided.ResultsThe majority of neurological disturbances reported in d-la episodes overlapped with ME/CFS symptoms. Of these, the most frequently reported d-la symptoms were motor disturbances that appear more prominent during severe presentations of ME/CFS. Both patient groups shared a history of gastrointestinal abnormalities and evidence of bacterial dysbiosis, although only preliminary evidence supported the role of lactate-producing bacteria in ME/CFS.LimitationsInterpretation of results are constrained by both the breadth of symptoms included in ME/CFS diagnostic criteria and the conservative methodology used for d-la symptom classification. Several pathophysiological mechanisms in ME/CFS were not examined.ConclusionsShared symptomatology and underlying microbiota–gut–brain interactions raise the possibility of a continuum of acute (d-la) versus chronic (ME/CFS) presentations related to d-lactate absorption. Measurement of d-lactate in ME/CFS is needed to effectively evaluate whether subclinical d-lactate levels affect neurological symptoms in this clinical population.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-017-1229-1) contains supplementary material, which is available to authorized users.

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The regulatory effects of lactic acid on neuropsychiatric disorders

et al. 2022

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Lactic acid is produced mainly in astrocytes in the brain and serves as a substance that supplies energy to neurons. In recent years, numerous studies identified the potential effects of lactic acid on the central nervous system and demonstrated its role in regulating brain function as an energy metabolism substrate or cellular signaling molecule. Both deficiency and accumulation of lactic acid cause neurological dysfunction, which further lead to the development of neuropsychiatric disorders, such as Major depressive disorder, Schizophrenia, Alzheimer’s disease, and Multiple sclerosis. Although an association between lactic acid and neuropsychiatric disorders was reported in previous research, the underlying pathogenic mechanisms remain unclear. Therefore, an in-depth understanding of the molecular mechanisms by which lactic acid regulates brain function is of significance for the early diagnosis and prevention of neuropsychiatric disorders. In this review, we summarize evidence that is focused on the potential mechanisms of lactic acid as a signaling molecule involved in the pathogenesis of neuropsychiatric disorders and propose a new mechanism by which lactic acid regulates brain function and disease through the microbiota–gut–brain axis to offer new insight into the prevention and treatment of neuropsychiatric diseases.

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Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Cited by 3 publications

References 118 publications

Effect of Nature Experience on Fronto-Parietal Correlates of Neurocognitive Processes Involved in Directed Attention: An ERP Study

Effect of Nature Experience on Fronto-Parietal Correlates of Neurocognitive Processes Involved in Directed Attention: An ERP Study

Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lactic acidosis: a systematic review

The regulatory effects of lactic acid on neuropsychiatric disorders

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