Cognitive function over the treatment course of depression in middle-aged patients: correlation with brain MRI signal hyperintensities

Neu, Peter; Bajbouj, Malek; Schilling, A.; Godemann, F.; Berman, R.; Schlattmann, Peter

doi:10.1016/j.jpsychires.2004.06.004

Cited by 115 publications

(82 citation statements)

References 45 publications

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“…Similar to the acute state, a specific pattern of deficits in remission remains to be determined, though evidence of CI is regularly found in domains also emphasized in the context of acute depression, that is, psychomotor function [19,24,25], attention [6,8,20,26], memory and learning [6,8,19,27,28], and executive function [6,18,19,26,[28][29][30].…”

Section: Over the Course Of Depressionmentioning

confidence: 99%

Cognitive Impairment Along the Course of Depression: Non-Pharmacological Treatment Options

et al. 2018

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Major Depressive Disorder (MDD) is one of the most common psychiatric disorders, with a large global impact on both the individual and the society. In this narrative review, we summarize neurocognitive deficits during acute and (partially) remitted states of depression. Furthermore, we outline the potential negative effect of cognitive impairment (CI) on functional recovery, and discuss the role of several variables in the development of CI for MDD patients. Though there is cumulating evidence regarding persistent CI in unipolar depression, research on treatment options specific for this patient group is still scarce. Hence the central aim of our review is to present non-pharmacological interventions, which are thought to reduce CI in affected MDD patients. We discuss cognitive remediation therapy (CRT), physical exercise, yoga, mindfulness-based therapy, and modern neuromodulation approaches like neurostimulation and neurofeedback training. In conclusion, we propose future directions for research on CI in depression. Looking further ahead, we suggest creative interventional designs that include a direct comparison of different non-pharmacological treatment approaches on neurocognition and functional outcome of MDD. Furthermore, additive and synergistic effects of CRT with other treatment approaches should be examined and compared to create multimodal and even personalized intervention programs.

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Section: Over the Course Of Depressionmentioning

confidence: 99%

Cognitive Impairment Along the Course of Depression: Non-Pharmacological Treatment Options

et al. 2018

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“…These results provide further support for the hypothesis that BDNF may be central to the development of depressive mood states (Lang et al 2004). In addition, two studies (Neves-Pereira et al 2002;Sklar et al 2002) suggest that the BDNF locus is associated with bipolar disorder.…”

Section: Neurotrophic Factorsmentioning

confidence: 99%

“…This could suggest that deficits are related to antidepressant medications. Conversely, memory deficits could persist after remission (Neu et al 2005), even in euthymic state (Kessing 1998). Thus, memory impairment may be linked to other factors than medication, such as other illness characteristics.…”

Section: Cognitive Deficits In Major Depressionmentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

226

126

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Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

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“…MDD patients are thought to exhibit pronounced SVF impairment due to a disorganized semantic retrieval strategy [10], attenuated category switching ability [8], or failure to inhibit irrelevant semantic activation [9]. According to the cognitive theory of major depression, patients have disorganized (biased) semantic representations and have trouble suppressing task-irrelevant thoughts or maladaptive rumination [11].…”

Section: Introductionmentioning

confidence: 99%

Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression

Takamura

Okamoto²,

Okada³

et al. 2016

Neuropsychobiology

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Background: Patients with major depressive disorder (MDD) exhibit cognitive impairment, and evidence suggests that the semantic version of the verbal fluency task is a reliable cognitive marker of the disorder. Here, using functional magnetic resonance imaging (fMRI), we investigated the dysfunction of neural processing in acute depression and examined the effects of a 6-week pharmacological intervention. Methods: Sixteen patients with MDD participated in 2 fMRI sessions, and 16 healthy control (HC) subjects participated in 1 fMRI session. During each fMRI session, the participants performed a semantic verbal fluency task. Brain activity during the task was compared between groups (MDD 1st fMRI vs. HC) and times (MDD 1st fMRI vs. 2nd fMRI). Results: Significant brain hypoactivation was observed in MDD patients at the prefrontal, lateral parietal, and limbic regions compared to HC, and MDD patients exhibited hyperactivation at the left precuneus compared to HC. Hypoactivity of the left dorsolateral prefrontal cortex (DLPFC) and hyperactivity of the precuneus were normalized with treatment. Conclusions: Hypoactivation of the left DLPFC and hyperactivation of the precuneus should be considered as dysregulation of anticorrelated brain networks during a cognitive demanding task. This failure of network regulation may be an important factor in the pathophysiology of MDD.

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Cognitive function over the treatment course of depression in middle-aged patients: correlation with brain MRI signal hyperintensities

Cited by 115 publications

References 45 publications

Cognitive Impairment Along the Course of Depression: Non-Pharmacological Treatment Options

Cognitive Impairment Along the Course of Depression: Non-Pharmacological Treatment Options

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression

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