Cognitive Function of Patients With Nasopharyngeal Carcinoma With and Without Temporal Lobe Radionecrosis

Cheung, Mei-chun; Chan, Agnes S.; Law, Stephen C.K.; Chan, James C.; Tse, Vincent K. C.

doi:10.1001/archneur.57.9.1347

Cited by 107 publications

(87 citation statements)

References 34 publications

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“…In addition, a number of neural psychology test studies have revealed that patients with cranial irradiation experienced a decrease in cognitive function (24). Previous studies have been limited to the WM due to radiation sensitivity.…”

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confidence: 99%

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

et al. 2017

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Abstract. The aim of the present study was to investigate the microstructural characteristics of the brain lobes following radiotherapy (RT) for patients with nasopharyngeal carcinoma (NPC) at distinct times. Diffusion tensor imaging (DTI) and 3D-T1-weighted imaging was performed in 70 age-and sex-matched subjects, 24 of whom were pre-treatment patients. The patients were divided into three groups, according to the time following completion of RT. Fractional anisotropy (FA) and gray matter (GM) volume were determined. The DTI data were analyzed using tract-based spatial statistics and the GM volume was analyzed using voxel-based morphometry (VBM). Compared with the pre-RT group, the mean FA values in the left parietal lobe white matter (WM) and right cerebellum decreased significantly in the post-RT 0-6 month group (P<0.05). In addition, the mean FA values in the right parietal lobe WM decreased significantly in the post-RT 6-12 month group (P<0.05), compared with the pre-RT group. The FA level in the right temporal lobe remained significantly decreased, compared with that in the pre-RT group (P<0.05) for 1 year after RT. Furthermore, compared with pre-RT group, the GM volume in the bilateral frontal lobe, right occipital lobe, left parietal lobe, right temporal lobe and left cerebellum decreased significantly in the post-RT 0-6 month group (P<0.05), and in the bilateral temporal lobe, parietal lobe, right frontal lobe and left cerebellum, the GM volume decreased significantly in the post-RT 6-12 month group (P<0.05). The GM volume in the right temporal lobe, bilateral frontal lobe and bilateral cerebellum remained significantly decreased compared with that in the pre-RT group (P<0.05) for 1 year after RT. A combination of DTI and VBM may be used to determine radiation-induced brain injury in patients treated for NPC.

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confidence: 99%

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

et al. 2017

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“…Data on neurocognitive functioning in patients with head and neck cancer (HNC) are primarily limited to eight small studies [8][9][10][11][12][13][14][15]. Six studies [8][9][10][11][12][13] evaluated the neurocognitive effects of potential radiation-induced brain injury.…”

Section: Introductionmentioning

confidence: 99%

“…Six studies [8][9][10][11][12][13] evaluated the neurocognitive effects of potential radiation-induced brain injury. The study samples included only patients with either nasopharyngeal or paranasal sinus tumors, in which treatment entailed incidental radiation to normal brain tissue and thus the potential for direct radiation damage.…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive function in patients with head and neck cancer undergoing primary or adjuvant chemoradiation treatment

Bond

Dietrich

Gilbert

et al. 2016

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Purpose Cancer and cancer therapy-related neurocognitive changes negatively affect quality of life, yet few studies have examined neurocognitive changes in patients with head and neck cancer. The purpose of this study was to evaluate neurocognitive performance in patients with head and neck cancer at baseline before starting treatment and 3 months after treatment completion to assess treatment-associated changes in performance. Methods Patients with head and neck cancer who were to receive primary or adjuvant chemoradiation (N = 55) underwent neuropsychological testing before and 3 months posttreatment. Changes in neurocognitive performance were assessed using a practice effect adjusted Reliable Change Index.Results At baseline, 38 % of patients exhibited global neurocognitive impairment. Posttreatment, 21.8 % demonstrated declines in neurocognitive performance in at least one domain. Declines in domain-specific performance ranged from 1.8 to 12.7 % with the greatest decline in language, specifically verb retrieval. Domain-specific improvements ranged from 0 to 7.3 %. Conclusions Patients had a high prevalence of baseline neurocognitive impairment. While neurocognitive performance posttreatment remained unchanged in the majority, almost 13 % suffered declines in language. Small percentages of patients exhibited improvements in their performance. Long-term effects and risk factors for neurocognitive decline in this population should be studied on a larger scale.

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“…Tang et al [35] reported that NPC patients with radiation-induced brain injury (RI) exhibited negative emotions, impaired cognitive function and quality of life (QOL). The accumulated studies showed that the radiation-induced functional impairments included the disorder of short-term memory [36], personality changes [37] and motor abilities [38], a marked anterograde memory impairment for verbal material [39], neuropsychological impairments in recent memory, immediate and delayed verbal recall, and immediate visual recall [40].…”

Section: Resultsmentioning

confidence: 99%

Identify the radiotherapy-induced abnormal changes in the patients with nasopharyngeal carcinoma

Wang

Zhao

Zhang³

et al. 2017

ADMET DMPK

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<p class="ADMETabstracttext">Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma, which often causes inevitable brain injury in the process of treatment. The majority of patients has no abnormal signal or density change of the conventional magnetic resonance imaging (MRI) and computed tomography (CT) examination in the long-term follow-up after radiation therapy. However, when there is a visible CT and conventional MR imaging changes, the damage often has been severe and lack of effective treatments, seriously influencing the prognosis of patients. Therefore, the present study aimed to investigate the abnormal changes in nasopharyngeal carcinoma (NPC) patients after RT. In the present study, we exploited the machine learning framework which contained two parts: feature extraction and classification to automatically detect the brain injury. Our results showed that the method could effectively identify the abnormal regions reduced by radiotherapy. The highest classification accuracy was 82.5 % in the abnormal brain regions. The parahippocampal gyrus was the highest accuracy region, which suggested that the parahippocampal gyrus could be most sensitive to radiotherapy and involved in the pathogenesis of radiotherapy-induced brain injury in NPC patients.</p>

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Cognitive Function of Patients With Nasopharyngeal Carcinoma With and Without Temporal Lobe Radionecrosis

Cited by 107 publications

References 34 publications

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

Neurocognitive function in patients with head and neck cancer undergoing primary or adjuvant chemoradiation treatment

Identify the radiotherapy-induced abnormal changes in the patients with nasopharyngeal carcinoma

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