Cognitive function in schizophrenia and its association with socio-demographics factors

Talreja, Bharti T; Shah, Saurabh; Kataria, Lakhan

doi:10.4103/0972-6748.123619

Cited by 44 publications

(49 citation statements)

References 46 publications

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“…This method was not used in the present study because a majority of patients with schizophrenia (70% or more) have cognitive dysfunction, including difficulties in attention, concentration, memory, language, and executive function. 33 Dialogue with subsequent agreement between co-researchers (researcher triangulation) was one of the major methods to increase trustworthiness in this study. 28 The 3 authors' combined clinical and research experience was considered to be complementary and of importance to the analysis.…”

Section: Trustworthinessmentioning

confidence: 99%

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Barriers, Benefits, and Strategies for Physical Activity in Patients With Schizophrenia

2014

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In accordance with patients' perceptions, there may be biopsychosocial determinants of physical activity behavior that are unique for this group of patients. Future studies should investigate whether physical activity interventions for patients with schizophrenia benefit from individual analyses of barriers and reward for physical activity in combination with the use of tailored strategies such as personal support and activity planning.

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Section: Trustworthinessmentioning

confidence: 99%

“…or gardening. 33 f Answers to a question about time spent per week in planned and structured physical exercise (eg, running, participating in aerobics, or ball games). 33 Uppsala University, and the Regional Research Council in Uppsala-Ö rebro region.…”

Section: Role Of the Funding Sourcementioning

confidence: 99%

Barriers, Benefits, and Strategies for Physical Activity in Patients With Schizophrenia

2014

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“…As far as we are aware, it remains unknown whether unaffected siblings of patients with a psychotic disorder perform below the expected level in school. Furthermore, cognitive functioning in psychotic disorder is associated with sociodemographic factors, such as childhood trauma and stress [ 3 ] and urban habitat [ 18 ]. Stress and altered functioning of the hypothalamic–pituitary–adrenal (HPA) axis, with harmful effects of stress and glucocorticoids on the brain is a possible explanation for this association [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Psychotic disorder and educational achievement: a family-based analysis

Frissen

Lieverse

Drukker

et al. 2015

Soc Psychiatry Psychiatr Epidemiol

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BackgroundEarly social and cognitive alterations in psychotic disorder, associated with familial liability and environmental exposures, may contribute to lower than expected educational achievement. The aims of the present study were to investigate (1) how differences in educational level between parents and their children vary across patients, their healthy siblings, and healthy controls (effect familial liability), and across two environmental risk factors for psychotic disorder: childhood trauma and childhood urban exposure (effect environment) and (2) to what degree the association between familial liability and educational differential was moderated by the environmental exposures.MethodsPatients with a diagnosis of non-affective psychotic disorder (n = 629), 552 non-psychotic siblings and 326 healthy controls from the Netherlands and Belgium were studied. Participants reported their highest level of education and that of their parents. Childhood trauma was assessed with the Dutch version of the Childhood Trauma Questionnaire-Short Form. Urban exposure, expressed as population density, was rated across five levels.ResultsOverall, participants had a higher level of education than their parents. This difference was significantly reduced in the patient group, and the healthy siblings displayed intergenerational differences that were in between those of controls and patients. Higher levels of childhood urban exposure were also associated with a smaller intergenerational educational differential. There was no evidence for differential sensitivity to childhood trauma and childhood urbanicity across the three groups.ConclusionIntergenerational difference in educational achievements is decreased in patients with psychotic disorder and to a lesser extent in siblings of patients with psychotic disorder, and across higher levels of childhood urban exposure. More research is required to better understand the dynamics between early social and cognitive alterations in those at risk in relation to progress through the educational system and to understand the interaction between urban environment and educational outcomes.

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“…[15]. As seen in some past Indian studies [16], the proportion of patients of schizophrenia with cognitive impairment was estimated at 70%. Using a confidence level of 95% and an absolute precision level of 10%, we obtained a sample of 38, out of the 70 patients we expected to seek within the age group of 18 -60 years.…”

Section: Sample Selection and Methodsmentioning

confidence: 99%

A Study of the Association between Psychotropic Drugs and Cognitive Dysfunction in Patients with Schizophrenia

Chaudhari¹,

Mazumdar²,

Nair³

et al. 2019

Indian Journal of Mental Health

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Background: Cognitive deficits among patients with schizophrenia are now recognized as being widely prevalent and one of the most disabling aspects of the illness, as they are associated with poor functional outcomes. Psychotropic medications and benzodiazepines, which are often used in these patients could impact cognition as could the extrapyramidal side-effects. Yet, here are hardly any Indian studies on the subject. The aim of this study was to determine whether cognitive dysfunction among patients with schizophrenia is associated with extrapyramidal symptoms, anticholinergic burden of psychotropic drugs and benzodiazepine dosage Methodology: 40 clinically stable, outpatients suffering from schizophrenia, without any pre-existing neurological disorders between the ages of 18 to 60 years, who had been compliant with medications were selected. Extrapyramidal symptoms (EPS) were assessed using the modified Simpson-Angus scale, anticholinergic burden (ACB) was evaluated using the Anticholinergic burden scale. The benzodiazepine dosage was noted. Cognition was assessed using the Stroop Color and Word Test and the Wisconsin Card sorting test. The correlations between scores on EPS and ACB and neuropsychological tests were carried out using partial correlations controlling for positive and negative symptoms. Results: There were no significant associations noted between extrapyramidal symptoms, anticholinergic burden, benzodiazepine dosage and performance on the neurocognitive tests used. Conclusion: Methodological differences make it difficult to construct comparisons across studies but there is some evidence to support our findings.

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Cognitive function in schizophrenia and its association with socio-demographics factors

Cited by 44 publications

References 46 publications

Barriers, Benefits, and Strategies for Physical Activity in Patients With Schizophrenia

Barriers, Benefits, and Strategies for Physical Activity in Patients With Schizophrenia

Psychotic disorder and educational achievement: a family-based analysis

A Study of the Association between Psychotropic Drugs and Cognitive Dysfunction in Patients with Schizophrenia

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