Cognitive function and ^99mTc-ECD brain SPECT are significantly correlated in patients with primary Sjögren syndrome: a case–control study

Abstract

Neuropsychological testing and (99m)Tc-ECD brain SPECT seem to be the most sensitive tools to detect subclinical CNS dysfunction in pSS. The strong correlation between cortical hypoperfusion in (99m)Tc-ECD brain SPECT and cognitive dysfunction suggests an organic aetiology of CNS dysfunction in pSS. These data should be confirmed in a larger study.

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

“…As Table 2 shows in items 2,4,5 and 6 of RAVLT test the difference between controls and PSS patients was close to the significance level (borderline). We believe that a larger sample could help understand the difference between the performance of PSS and healthy controls in other parts of the test; thus, confirming that PSS Brazilian patients show critical memory impairment, as presented in other studies 22,18,23 .…”

“…Memory and executive function are the most common cognitive alterations observed in PSS 22,18,23 . In the present study, we found a significant difference in cognitive performance between PSS patients and controls in conceptual flexibility (i.e., inhibition control), one aspect of executive function.…”

Prevalence of Sjögren's syndrome with dementia in a memory clinic

“…These contradicting results may stem largely from the heterogeneous pathology of CNS SS, in which both leukocytoclastic angiitis and lymphocytic infiltration are associated in the process [5,12].…”

“…CNS SS with cognitive decline also demonstrates neuroradiaological changes in the brain: magnetic resonance imaging (MRI) frequently shows small punctate lesions in the perivascular and subcortical white matter of the brain [10,11], while some appears to be normal [5,12]. These contradicting results may stem largely from the heterogeneous pathology of CNS SS, in which both leukocytoclastic angiitis and lymphocytic infiltration are associated in the process [5,12].…”

Central and peripheral neurological complications of primary Sjögren's syndrome

“…Also common in pSS, and independently of depressive disorders, are cognitive changes with poor concentration and memory and abnormalities in neuropsychometric testing, including executive dysfunction, visuospatial disorders and long-or short-term memory deficits [5,64]. Brain MRI is usually normal (80% of the cases) or can revealed white matter lesions of the fronto-parietal subcortical regions [5,64].…”