Cognitive function and platelet membrane fluidity in Alzheimer's disease

Zubenko, George S.; Huff, F. Jacob; Becker, James T.; Beyer, Julia; Teply, Ivana

doi:10.1016/0006-3223(88)90227-2

Cited by 13 publications

(4 citation statements)

References 60 publications

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“…These differences are important enough to make results from clinical series of cases found in more highly selected populations less generalizable to the general population, which is the population of interest for prevalence and prevention research as well as research aiming to improve patient care [26,27]. Use of highly selected study populations likely explains why many “discoveries” in AD research have not been enduring because they were not reproducible in more representative populations (e.g., platelet membrane fluidity [28,29]).…”

Section: Experience Using the Group Health Medical Records System mentioning

confidence: 99%

Passive case‐finding for Alzheimer's disease and dementia in two U.S. communities

Knopman

Petersen

Rocca

et al. 2011

Alzheimer's & Dementia

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Passive surveillance for disease is a public health approach that relies on documentation available within existing health records for the region or communities being studied. Its 2 primary advantages over active case-finding are the lower cost of research and the lower burden on the population studied. The effectiveness of passive case-finding depends on the comprehensiveness of the healthcare coverage in a given community and the adequacy of the available medical records. The Rochester Epidemiology Project has permitted dementia case detection for Olmsted County, Minnesota, using a medical records-linkage system. These data were compared with case ascertainment using direct assessment of individuals in an epidemiologic study of the same community. At Group Health Research Institute, investigators compared dementia and Alzheimer’s disease cases detected using an electronic medical record database search with those identified by a parallel active case-finding study. The advantages and disadvantages of passive case-finding are discussed, concluding that the purpose of the study should determine the case-finding approach that is employed.

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Section: Experience Using the Group Health Medical Records System mentioning

confidence: 99%

Passive case‐finding for Alzheimer's disease and dementia in two U.S. communities

Knopman

Petersen

Rocca

et al. 2011

Alzheimer's & Dementia

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“…A possible familial basis for this subtype has been proposed based on life table analysis of familial cases [19], This hypoth esis was not supported in several other investigations [17,35,46], most of which, however, defined family his tory without controlling for whether or not relatives lived to the age of expression of AD. One study [47] has suggested that prominent language impairment may be associated with an abnormality of platelet membrane fluidity that may be genetically determined.…”

Section: Commentmentioning

confidence: 99%

Prevalence and Prognostic Value of Neurologic Abnormalities in Alzheimer's Disease

Huff

Belle

Shim

et al. 1990

Dement Geriatr Cogn Disord

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The prevalence of abnormal neurologic symptoms and signs in mildly to moderately demented patients with Alzheimer''s disease (AD) was determined by comparison with healthy control subjects, and abnormal findings in AD were examined in relation to progression of dementia, as reflected in the annual rate of change in scores on a dementia scale. Abnormalities on mental status testing were more prevalent in AD than abnormalities on symptom scales or findings on the remainder of the neurologic examination. Recent memory impairment was the most prevalent abnormality, whereas impaired object naming was most strongly associated with progression of dementia. Prominent impairment of naming and other language abilities early in the course of dementia may identify a subtype of AD characterized by more rapid progression.

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“…Zubenko et al [6] found increased PMF in 50% of AD subjects who met NINCDS/ADRDA criteria. Those with increased PMF had more evidence of left parietal dysfunction (based on psychological test results) than patients with normal PMF.…”

Section: Introductionmentioning

confidence: 99%

Clinical Diagnosis of Alzheimer's Disease

Burns¹

1991

Dement Geriatr Cogn Disord

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There are a number of ways in which a clinical diagnosis of dementia of the Alzheimer type can be made – the application of clinical criteria is the commonest but ancillary techniques such as neuroimaging, peripheral markers and neurophysiological investigations are helpful. The NINCDS/ADRDA criteria are the most consistent in correctly predicting, during life, who will have the neuropathological findings of Alzheimer''s disease and as such represent the gold standard for clinical diagnosis. Platelet membrane fluidity and the results of nasal biopsy may also be helpful but the specificity of abnormalities for Alzheimer''s disease has yet to be established. Computerised tomography and single photon emission tomography are the two most applicable and widely available neuroimaging techniques and, with single photon emission tomography, characteristic patterns of blood flow distribution are seen in Alzheimer''s disease. Even with the application of clinical guidelines and appropriate use of ancillary investigations, there is still diagnostic misclassification in up to 20% of cases for the refinement of clinical criteria and prospective clinico-pathological studies along with clinical criteria for other types of dementia are required.

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Cognitive function and platelet membrane fluidity in Alzheimer's disease

Cited by 13 publications

References 60 publications

Passive case‐finding for Alzheimer's disease and dementia in two U.S. communities

Passive case‐finding for Alzheimer's disease and dementia in two U.S. communities

Prevalence and Prognostic Value of Neurologic Abnormalities in Alzheimer's Disease

Clinical Diagnosis of Alzheimer's Disease

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