Cognitive function and plasma BDNF levels among manganese-exposed smelters

Zou, Yue; Li, Qing; Zeng, Xianmin; Shen, Yongchun; Zhong, Ying; Liu, Jing; Li, Qin; Chen, Kangcheng; Lv, Yingnan; Huang, Damin; Liang, Guiqiang; Zhang, Wei; Chen, Lang; Yang, Yiping; Yang, Xiaobo

doi:10.1136/oemed-2013-101896

Cited by 37 publications

(24 citation statements)

References 42 publications

(44 reference statements)

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“…Meanwhile, our previous studies showed that plasma BDNF levels are also associated with the extent of Mn exposure and cognitive impairments in Mn-exposed workers Zou et al, 2014). In the present study, the plasma BDNF levels were negatively correlated with the Mn treatment dose; by contrast, the plasma BDNF levels were positively correlated with the hippocampal BDNF levels.…”

Section: Discussioncontrasting

confidence: 51%

“…However, whether plasma BDNF can be a biomarker of Mn-induced cognitive deficits in the body remains unknown. Combined with our previous study Zou et al, 2014), plasma BDNF levels are associated with Mn exposure levels and cognitive impairment in Mn-exposed workers. Therefore, we assessed plasma BDNF levels to investigate whether plasma BDNF can be a reliable effect biomarker of Mn…”

Section: Introductionmentioning

confidence: 69%

“…Hence, we have carried out a series of studies to investigate these relationships. Our results Zou et al, 2014) revealed that Mn exposure is associated with cognitive deficits and decreased plasma BDNF levels.…”

Section: Introductionmentioning

confidence: 74%

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Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway

Liang

Zhang

et al. 2015

Food and Chemical Toxicology

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 69%

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Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway

Liang

Zhang

et al. 2015

Food and Chemical Toxicology

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“…On the other hand, high manganese levels can be neurotoxic. Excessive levels of manganese lead to cognitive impairments and extrapyramidal symptoms 11 .…”

Section: Introductionmentioning

confidence: 99%

Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats

Liu

Mei

et al. 2017

Sci Rep

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The therapeutic effects of iron, zinc and magnesium trace elements, as well as rifaximin were investigated and compared in HE rats. In this study, HE rats were treated with either ferrous sulfate (HE-Fe, 30 mg/kg/day), zinc sulfate (HE-Zn, 30 mg/kg/day), magnesium sulfate (HE-Mg, 50 mg/kg/day) or rifaximin (HE-Rf, 50 mg/kg/day), which was mixed with water and administered orally for 61 days. The Morris water maze (MWM) and open-field tests were used to evaluate cognitive and locomotor function. The blood ammonia levels before and after administration of the glutamine challenge test, manganese concentration and glutamine synthetase (GS) activity were measured. Significantly longer MWM escape latencies, less locomotor activity, higher blood ammonia levels, higher brain manganese concentrations and higher GS activity were observed in HE rats. However, HE-Mg and HE-Rf rats had significantly shorter MWM escape latencies, increased locomotor activity, lower blood ammonia, lower brain manganese concentrations and lower GS activity. Partial improvements were observed in HE-Fe and HE-Zn rats. The results indicated that oral administration of magnesium can significantly improve the cognitive and locomotor functions in HE rats by reducing the brain manganese concentration and regulating GS activity.Hepatic encephalopathy (HE) is a major complication of cirrhosis and (or) portal-systemic shunting 1 . Its pathogenesis is not completely clear. It has been suggested that nitrogen metabolism dysfunction may cause neurological symptoms 2 . HE significantly affects the quality of daily life and may ultimately lead to death; however, HE can be reversed with the appropriate treatment 1, 2 . HE patients are known to have higher levels of ammonia in their blood. Thus, current HE treatments focus on non-absorbable disaccharides (e.g., lactulose) or antibiotics (e.g., rifaximin) to reduce ammoniagenesis in the intestines and lower blood ammonia levels 3 . Recent studies showed that trace element concentrations varied in cirrhotic patients with HE 4 . Lower serum zinc, magnesium and iron but higher serum manganese and copper were reported in cirrhotic patients [5][6][7] . Zinc, magnesium, and iron are co-enzymes of a variety of metabolic enzymes. Deficiencies in zinc, magnesium and iron levels may lead to metabolic disorders and negatively impact behavior and cognition [8][9][10] . On the other hand, high manganese levels can be neurotoxic. Excessive levels of manganese lead to cognitive impairments and extrapyramidal symptoms 11 . Oral administration of zinc effectively improves HE symptoms 12 . However, whether oral administration of iron or magnesium is also beneficial is not known. Previous studies demonstrated that trace elements, such as iron and magnesium, can influence manganese absorption in the intestines 13,14 . We hypothesize that iron and magnesium supplementation may improve HE by reducing intestinal manganese absorption and subsequently

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“…The Montreal Cognitive Assessment (MoCA) is a neurocognitive function test which rapidly screens for mild cognitive impairment with high sensitivity and specificity 20–22. We assessed the affect of Mn exposure on the nervous system using the MoCA as a cognitive screening tool 23. The Non-Motor Symptoms Scale (NMSS) and the Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT) are neurobehavioral function tests.…”

Section: Methodsmentioning

confidence: 99%

Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study

Zou

Liu

et al. 2014

BMJ Open

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ObjectiveTo determine the relationship between biomarkers of exposure, disease and susceptibility, and early health effects and long-term diseases related to occupational manganese (Mn) exposure.DesignBaseline survey of a longitudinal cohort study of workers in a ferromanganese refinery.ParticipantsA total of 1888 individuals (1197 men, 691 women; average seniority 15.34 years) were enrolled in the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study. Participants were between 18 and 60 years of age (mean 40.31 years), had worked in the ferromanganese refinery for at least 1 year and lived in the local area.ResultsThe GXMEWHC study included a baseline survey. Participants were divided into four groups according to manganese (Mn) cumulative exposure index (Mn-CEI) levels: an internal control group (Mn-CEI <1.0 mg/m3 year), a low exposure group (1.0 mg/m3 year≤Mn-CEI<2.0 mg/m3 year), a medium exposure group (2.0 mg/m3 year≤Mn-CEI<5.0 mg/m3 year) and a high exposure group (Mn-CEI≥5.0 mg/m3 year). Genome-wide association studies of quantitative trait loci and binary trait loci in 500 Mn-exposed workers were performed using Illumina Infinium HumanExome BeadChip arrays. Stored plasma, DNA, hair and urine are available for further study. Participants will be followed up every 3 years.ConclusionsThe GXMEWHC study provides abundant data for exploring the systemic health effects of occupational Mn exposure using biomarkers of exposure, disease and susceptibility.

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Cognitive function and plasma BDNF levels among manganese-exposed smelters

Abstract: Mn exposure may be associated with decreased plasma BDNF levels and cognition impairment in this large cross-sectional study.

Cited by 37 publications

References 42 publications

Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway

Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway

Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats

Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study

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