Cognitive Frontal Lobe Dysfunction in Obsessive-Compulsive Disorder

Schmidtke, Klaus; Schorb, Alexander; Winkelmann, G.; Hohagen, Fritz

doi:10.1016/s0006-3223(97)00355-7

Cited by 160 publications

(100 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are in agreement with previous researches [29,30]. To explain this finding, it can be said that the executive function deficits may be related to the problems in organization and strategization of the cognitive stimuli and resources for achieving the highest efficiency [6].…”

Section: Discussionsupporting

confidence: 93%

Comparison of Executive Function in Obsessive Compulsive Disorder Patients With Good Insight, Poor Insight and Healthy People

Toobaei

Shairi

Shams

et al. 2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: This research seeks to make a comparison between executive functions of the obsessive compulsive disorder (OCD) patients, with poor and high insight levels and normal people. Patients and Methods: In this casual comparative study, 22 OCD patients with high insight level, 5 OCD patients with poor insight level (based on YBOCS' 11th item score) and 23 normal subjects were selected using convenience sampling technique. The subjects were evaluated using two groups of clinical and neuropsychiatric instruments. The clinical instruments included Y-BOCS, BDI-II and GHQ-12. The executive functions were assessed using the Tower of London test, the Stroop and the Wisconsin Card Sorting tests. Results:The obtained results showed a significant difference between OCD patients and normal people in a number of executive functions. However, comparison between OCD patients with high and poor insight levels showed no significant difference in the executive functions variables. Conclusions: Executive functions (EF) may contribute to the psychopathology of OCD. Therefore examining EF can play an important role in assessment and treatment of OCD.

show abstract

Section: Discussionsupporting

confidence: 93%

Comparison of Executive Function in Obsessive Compulsive Disorder Patients With Good Insight, Poor Insight and Healthy People

Toobaei

Shairi

Shams

et al. 2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Similarly, in another study, no correlation was found between neuropsychological test scores and YBOCS scores of patients with OCD (46). Failure to determine a correlation between YBOCS scores and neuropsychological findings appears to be the common conclusion of many studies (5,14,47,48).…”

Section: Discussionmentioning

confidence: 92%

Executive Functions of Obsessive Compulsive Disorder and Panic Disorder Patients in Comparison to Healty Controls

Kurt¹,

Yıldırım

Topçuoğlu

2017

Arch Neuropsychiatr

View full text Add to dashboard Cite

“…Although OCD patients are not markedly impaired on simple reversal learning, they have impairments in other tasks sensitive to OFC function such as alternation learning, a task related to reversal learning (Freedman et al, 1998). They also show impairments on laboratory tests of frontal lobe function involving response shifting and inhibitory processing that correlate with the severity of their symptoms (Veale et al, 1996;Rosenberg et al, 1997;Schmidtke et al, 1998;Hollander and Rosen, 2000). The serotonergic system is also implicated in OCD, for example, via the therapeutic effects of specific serotonin reuptake inhibitors (SSRIs) (Baumgarten and Grozdanovic, 1998;El Mansari and Blier, 2006).…”

Section: Obsessive-compulsive Disorder and Reversal Learningmentioning

confidence: 99%

Dissociable Effects of Selective 5-HT2A and 5-HT2C Receptor Antagonists on Serial Spatial Reversal Learning in Rats

Boulougouris

Glennon

Robbins

2007

Neuropsychopharmacol

199

183

View full text Add to dashboard Cite

Serotonin (5-hydroxytryptamine, or 5-HT) is strongly implicated in the ability to shift behavior in response to changing stimulus-reward contingencies. However, there is little information on the contribution of different 5-HT receptors in reversal learning. Thus, we investigated the effects of systemic administration of the 5-HT 2A antagonist M100907 (0, 0.01, 0.03, and 0.1 mg/kg, i.p.) and the 5-HT 2C antagonist SB 242084 (0, 0.1, 0.3, and 1.0 mg/kg, i.p.) on the performance of an instrumental two-lever spatial discrimination and serial spatial reversal learning task, where both levers were presented and only one was reinforced. The rat was required to respond on the reinforced lever under a fixed ratio 3 schedule of reinforcement. Following attainment of criterion, a series of within-session reversals was presented. Neither M100907 nor SB 242084 altered performance during spatial discrimination and retention of the previously reinforced contingencies. M100907 significantly impaired reversal learning by increasing both trials to criterion (only at the highest dose) and incorrect responses to criterion in Reversal 1, a pattern of behavior manifested as increased perseverative responding on the previously reinforced lever. In contrast, SB 242084 improved reversal learning by decreasing trials and incorrect responses to criterion in Reversal 1, with significantly fewer perseverative responses. These data support the view that 5-HT 2A and 5-HT 2C receptors have distinct roles in cognitive flexibility and response inhibition. The improved performance in reversal learning observed following 5-HT 2C receptor antagonism suggests these receptors may offer the potential for therapeutic advances in a number of neuropsychiatric disorders where cognitive deficits are a feature, including obsessive-compulsive disorder.

show abstract

Cognitive Frontal Lobe Dysfunction in Obsessive-Compulsive Disorder

Cited by 160 publications

References 39 publications

Comparison of Executive Function in Obsessive Compulsive Disorder Patients With Good Insight, Poor Insight and Healthy People

Comparison of Executive Function in Obsessive Compulsive Disorder Patients With Good Insight, Poor Insight and Healthy People

Executive Functions of Obsessive Compulsive Disorder and Panic Disorder Patients in Comparison to Healty Controls

Dissociable Effects of Selective 5-HT2A and 5-HT2C Receptor Antagonists on Serial Spatial Reversal Learning in Rats

Contact Info

Product

Resources

About