Cognitive Dysfunction, Mood Disorders, and Fatigue as Complications of Cancer

Dietrich, Jörg; Parsons, Michael

doi:10.1007/978-3-319-57901-6_12

Cited by 4 publications

(5 citation statements)

References 260 publications

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“…Depression is common in women receiving therapy for the treatment of breast cancer (Reece, Chan, Herbert, Gralow, & Fann, 2013), and some treatment side effects may exacerbate mood disturbance due to other neurocognitive changes commonly experienced as a result of cancer therapies (Dietrich & Parsons, 2018;Winocur, Johnston, & Castel, 2018). Women with breast cancer are at long-term increased risk for depression, including both severe episodes leading to hospitalization and use of antidepressants (Suppli et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Recovery in early stage breast cancer—An Australian longitudinal study

Edward

Chipman²,

Stephenson

et al. 2019

Int J of Nursing Practice

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Background The majority of breast cancer patients will experience some level of emotional distress, with some patients having long‐term psychological maladjustment. Personal and social resources play a role in recovery yet the interplay between these factors warrants further examination. This study aimed to investigate the interaction of psychosocial factors impacting women in their breast cancer trajectory, at 2 years or less following diagnosis (stages I‐III). Design A longitudinal cohort study approach was used in this study. Methods The sample consisted of n = 49 participants. Data were collected between June 2013 and October 2013 and followed for 12 months across the trajectory of the disease. Results The mean age was 56.6 years (SD 11.6 years). Most participants had stage I or stage II breast cancer. Time (over three time points—4 weeks, 6 months, and 12 months) after diagnosis was significantly associated with the body image (P = .003) and age (P = .004). Conclusion Older women with breast cancer reported less concern regarding body image than their younger peers. These findings suggest that posttreatment younger women may require access to psychological support posttreatment.

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Section: Discussionmentioning

confidence: 99%

Recovery in early stage breast cancer—An Australian longitudinal study

Edward

Chipman²,

Stephenson

et al. 2019

Int J of Nursing Practice

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“…These involve the cancer, the side effects of cancer treatments, comorbid and psychological conditions (Dietrich & Parsons, 2018).…”

Section: Table (5)mentioning

confidence: 99%

Effectiveness of applying fatigue Nursing Guidelines on Oncology Patient Health Outcome

Elshahat¹,

Sherief

Shaheen³

et al. 2019

Port Said Scientific Journal of Nursing

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Background: Cancer related fatigue recognizes as one of the most regularly stated and distressing side effects reported by most of cancer patients and significant has long-term effect on the quality of life. Indeed, Fatigue can affect on the patient's life including physical, psychological, social and spiritual aspects. Aim: evaluate the effect of applying fatigue nursing guidelines on oncology patient health outcome. Research design: Quasi experimental design was used in this study. Sample: A convenient sample of 94 cancer patients with a fatigue reported 4 or more on a 0 to 10 numeric screening scale. Setting: the study was conducted in oncology unit at Mansoura University and Port Said General Hospitals. Methods: The study implement the National Comprehensive Cancer Network guidelines for cancer related fatigue, Functional Assessment of Chronic Illness Therapy Fatigue Scale and Fatigue management barriers were measured at baseline, one month, and three months after intervention. Results: Participants experienced significant improvements in fatigue degrees at one-month assessment, and these improvements were continued at three-month assessment. Conclusion: The nursing fatigue guideline based on the National Comprehensive Cancer Network fatigue guideline was effective in reducing fatigue severity.

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“…1,2 Chronic use of such substances may often be accompanied by un (under) diagnosed psychiatric co-morbidities. 3 Treatment of cancer is reported to be commonly associated with cognitive alterations [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] (CA, including cognitive impairmenteCIe that refers to those secondary changes, denoting a reduction in an individual's mental abilities including but mostly limiting to perception, attention, language, action planning, learning and memory, thinking, reasoning, understanding, and problem solving; Cognitive disorders, CD refers to a set of disorders that significantly impairs the cognitive function of an individual to the point where normal functioning in society is impossible without treatment) and emotional frailty (EF). 19,20 There are epidemiological, longitudinal and biomarker based studies that reports of the effect of the radiological, surgical or chemotherapeutic effects on CA/EF among cancer survivors, notably from breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…As such CA are common during or after chemotherapy, they are popularly referred in cancer literature as "Chemobrain" or "Chemofog". [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Certain cancer longitudinal studies that included baseline assessments for CA revealed a high prevalence of neurocognitive dysfunction, in treatment naïve states. Prevalence of such CA during, posttreatment and survival period among HNSCC patients to extent of 47% of the study population.…”

Section: Introductionmentioning

confidence: 99%

Risk of cognition alteration and emotional frailty via circulating transcriptome in treatment naïve head and neck squamous cell cancer patients

Anusa

Thavarajah

2019

Journal of Oral Biology and Craniofacial Research

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Background: There is a dearth of research examining the association between differential expression (DE) of genetic transcritome associated with cognition alteration (CA) and emotional frailty (EF) in treatment naïve head and neck squamous cell carcinoma (HNSCC) patients. The present study was undertaken to identify the DE of mRNA of CA-EF in HNSCC tumor and correlate with clinical and other known genetic factors that promote oncogenesis as well as CA-EF. Material and methods: Using Genome-Wide Association Studies, putative genes associated with CA-EF(Prixie Fixie score ≥0.10) were identified. The DE of the mRNA of the thus selected genes were obtained from The CANCER GENOME ATLAS-HNSCC patients along with clinical details. The DE of mRNA pertaining to known factors such as inflammation, serotonergic and dopaminergic functions as well as clinical parameters were studied for association with the risk of DE of CA-EF. Appropriate statistics were performed and P ≤ 0.05 was taken as significant. Results: A total of 520 HNSCC patients formed study group. There were 77 (14.81%) patients at risk for CD, 41 (7.9%) for CI and 113 (21.73%) for EF risk. In all, 103 (19.81%) HNSCC patients of this cohort had DE of mRNA of genes associated with CA. Inflammation, circadian genes, mTOR pathway, invasion and metastasis set of genes had a significant association with the risk of DE of CA-EF. Discussion: Transcriptome's have been postulated to mediate CA-EF by targeted action on human brain. Differential Expression of putative genes associated with CA-EF have been demonstrated in HNSCC tumor. These DE could predispose the patients to CA-EF by the action of gene-environmental as well as psycho-social constructs. As CA-EF could adversely influence the treatment and alter the quality of life among survivors, screening for CA-EF at HNSCC presentation becomes imperative.

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Cognitive Dysfunction, Mood Disorders, and Fatigue as Complications of Cancer

Cited by 4 publications

References 260 publications

Recovery in early stage breast cancer—An Australian longitudinal study

Recovery in early stage breast cancer—An Australian longitudinal study

Effectiveness of applying fatigue Nursing Guidelines on Oncology Patient Health Outcome

Risk of cognition alteration and emotional frailty via circulating transcriptome in treatment naïve head and neck squamous cell cancer patients

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