Cognitive dysfunction in obsessive‐compulsive disorder

Okasha, Ahmed; Rafaat, M.; Mahallawy, N. A. El; Nahas, G. El; Dawla, A. Seif El; Sayed, Mona El; Kholi, S. El

doi:10.1034/j.1600-0447.2000.101004281.x

Cited by 90 publications

(78 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although most studies suggest that performance of OCD patients was similar to those of healthy controls [Zielinski et al, 1991;Abbruzzese et al, 1995;Gross-Isseroff et al, 1996;Abbruzzese et al, 1997;Deckersbach et al, 2000;Moritz et al, 2001;Moritz et al, 2002], some studies have reported deficits in WCST [Boone et al, 1991;Hymas et al, 1991;Lucey et al, 1997;Okasha et al, 2000;Tukel et al, 2012].…”

Section: Discussionmentioning

confidence: 98%

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Tükel

Gürvit

Özata

et al. 2012

American J of Med Genetics Pt B

View full text Add to dashboard Cite

In the present study, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism is associated with obsessive-compulsive disorder (OCD) and also investigated the association between the BDNF Val66Met polymorphism and the performance on tests measuring executive functions in a sample of patients with OCD. A total of 100 patients diagnosed with OCD according to DSM-IV criteria and 110 control subjects were included in this study. Single nucleotide polymorphism (G/A) leading to Val to Met substitution at codon 66 in BDNF was screened in the DNA samples of all participants. The genotype frequencies of BDNF Val66Met polymorphism were compared in OCD patients and healthy controls. The four subgroups of OCD and healthy control subjects, determined according to being Val homozygous or carrying a Met allele, were also compared according to their performance in a battery of neuropsychological tests of executive functions and verbal memory. There was no significant difference for the allele and genotype distributions of BDNF Val66Met polymorphism between the OCD and healthy control groups. Compared to the other three subgroups, OCD-Met carriers were slower on Trail-Making Test part A (TMT A), part B (TMT B) score and its speed-corrected score (TMT B-A). OCD-Met carriers had also poor performance on verbal fluency tasks and several CVLT measures compared only to the healthy control-Met carriers. These results demonstrate that the BDNF Val66Met polymorphism does not appear to be a risk factor for OCD. However, the presence of a BDNF Met allele, which is a known attenuator of BDNF activity, may be associated with a poorer executive functioning in OCD.

show abstract

Section: Discussionmentioning

confidence: 98%

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Tükel

Gürvit

Özata

et al. 2012

American J of Med Genetics Pt B

View full text Add to dashboard Cite

show abstract

“…Previous studies demonstrated that patients with OCD exhibit extensive cognitive functional dysfunction including the domains of attention, memory, abs tract thinking, and spatial memory 6,7 . Research has shown that OCD patients with depression have obviously decreased executive function 8 .…”

Section: Discussionmentioning

confidence: 99%

Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder

Guo

Zhao

et al. 2014

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Objective: To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD). Method: Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST). Results: The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors. Conclusion: OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment.Keywords: obsessive-compulsive disorder, regional cerebral blood flow, cognitive function. ResumoObjetivo: Estudar a relação entre a perfusão sanguínea regional cerebral e as funções cognitivas em pacientes com transtorno obsessivo compulsivo (TOC). Método: Foram estudados 139 pacientes com TOC e 139 controles. As imagens do fluxo sanguíneo cerebral foram feitas por single photon emission computed tomography e o radioactivity rate (RAR) foi calculado usando como referência a radioatividade do córtex cerebelar. As funções cognitivas foram avaliadas através do Wisconsin Card Sorting Test (WCST). Resultados: O RAR do lobo pré-frontal, do lobo temporal anterior e do lobo occipital direito foram mais elevados nos pacientes do que nos controles (P<0.05). Quanto ao WCST, os escores de números corretos (P<0.01) e de classificação (P<0.05) foram menores no grupo TOC do que nos controles; entretanto, os escores de erros e de erros persistentes nos controles foram mais elevados do que nos pacientes (P<0.01). O RAR do lobo pré-frontal direito estava relacionado de modo negativo com os números corretos; o RAR do lobo temporal anterior apresentava correlação positiva com os erros; o RAR do lobo pré-frontal direito e do tálamo esquerdo apresentavam correlação positiva com erros persistentes. Conclusão: Pacientes com TOC apresentaram perfusão sanguínea cerebral mais intensa no lobo pré-frontal e no lobo temporal anterior. O lobo pré-frontal direito, o lobo temporal e o tálamo esquerdo podem estar relacionados com alterações cognitivas.Palavras-chave: transtorno obsessivo-compulsivo, fluxo sanguíneo regional cerebral, função cognitiva.Obsessive-compulsive disorder (OCD) is an intractable psychiatric condition. OCD morbidity is 2-3%, which severely affects patients' quality of life 1 . In order to investigate the biological basis underlying changes in cerebral function in patients with OCD, we assessed cerebral blood flow (CBF) with single-photon emission computed tomograph...

show abstract

“…Wisconsin Card Sorting Test (WCST) is a widely used neuropsychological test that measures the ability of set-shifting. There are studies demonstrating the impairment in this function in patients with OCD (6,7,8,9). On the other hand, there are also studies published that conclude that there are no impairments of set-shifting in OCD (10,11,12,13).…”

Section: Introductionmentioning

confidence: 98%

Executive Functions of Obsessive Compulsive Disorder and Panic Disorder Patients in Comparison to Healty Controls

Kurt¹,

Yıldırım

Topçuoğlu

2017

Arch Neuropsychiatr

View full text Add to dashboard Cite

Cognitive dysfunction in obsessive‐compulsive disorder

Abstract: OCD patients have a characteristic pattern of cognitive dysfunction that differs among patients of varied severity, chronicity and symptom type. We suggest a striatofrontoparietal neural pathophysiology. OCD seems to be a heterogeneous disorder, both clinically and pathophysiologically.

Cited by 90 publications

References 18 publications

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Brain‐derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive–compulsive disorder

Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder

Executive Functions of Obsessive Compulsive Disorder and Panic Disorder Patients in Comparison to Healty Controls

Contact Info

Product

Resources

About