Cognitive Dysfunction in Diabetic Patients with Special Reference to Age of Onset, Duration and Control of Diabetes

Abstract

Aims of this study was to determine the relationship between diabetes and cognitive impairment is respect of the age of onset and duration of diabetes, other complication of diabetes mellitus and effect of short term glycemic control on cognitive impairment. In the clinical study 50 diabetic patients were examined clinically for evidence of cognitive dysfunction by "Kolkata Cognitive Screening Battery". The scores were compared with the normative data on global cognitive functioning in a population within an urban Indian context. Those having cognitive impairment, follow up was done for six months with adequate anti-diabetic drugs to control their blood sugar strictly (HbA1C <7%). Those who had adequate blood sugar control were again interviewed similarly. The scores were compared with previous values. Results show that cognitive dysfunction was associated with diabetes. Recognition, fluency and immediate memory were most commonly affected. Calculation was least affected. No significant correlation found between cognitive decline with either duration or age of onset of diabetes. The cognitive decline appeared to be reversible as improvement of some mental faculties after strict blood sugar control. In conclusion we have found that cognitive decline was associated with diabetes but not directly related to the duration and age of onset of diabetes. On the other hand, control of diabetes lead to improvement of cognitive function.

Cognitive Impairment Among Older Adults With Diabetes Mellitus in Puducherry: A Community-Based Cross-Sectional Study

“…The present study could not observe a favorable association of physical activity with cognitive impairment. There was no association between the duration of diabetes and cognitive impairment, which was similar to the results obtained in a study by Mukherjee et al [17].…”

“…Female gender, widowhood status, illiteracy, and the presence of probable symptomatic hypoglycemia were found to be significant predictors of cognitive impairment in multivariate analysis ( Table 5). [14][15][16][17][18]. This difference in proportion was probably due to variation in the study population, study tool, and different cutoff scores used for defining the cognitive impairment.…”

Relationship between self-reported weight change, educational status, and health-related quality of life in patients with diabetes in Luxembourg

“…Indeed, health-related quality of life (HRQOL) is influenced by clinical changes that are consequences of treatment and monitoring of the disease [ 3 – 5 ]. Furthermore, diabetes has multiple physical and psychological effects on patients [ 6 ].…”

Cognitive Dysfunction in Diabetes Mellitus

“…Control of DM can help in improving cognitive function of the patients. Other habits such as smoking, poor control of sugar intake as well as life style can enhance the effect of cognitive impairment [32].…”