Cognitive deficits in clinical and familial high risk groups for psychosis are common as in first episode schizophrenia

The association between cognitive deficits and depressive symptoms in at-risk mental state: A comparison with first-episode psychosis

“…While cognitive performance in ARMS and FEP has been previously compared (Keefe et al, 2006;Eastvold et al, 2007;Simon et al, 2007Simon et al, , 2012Ozgurdal et al, 2009;Jahshan et al, 2010;Kim et al, 2011;Üçok et al, 2013), the severity of depressive symptoms in ARMS and FEP participants has not been reported. In addition, few studies have examined the relationship between depressive symptoms and cognitive deficits in ARMS participants.…”

The muscarinic system, cognition and schizophrenia

“…Likewise, longitudinal studies examining symptom progression amongst high-risk adolescents depict a progressive decline in various cognitive domains, including verbal and working memory (Lencz et al, 2006;Simon et al, 2007), attention (Wood et al, 2008) and executive functioning (Kim et al, 2011;Üç ok et al, 2013). Such progressive developmental or prodromal cognitive decline is not a feature of other psychiatric disorders such as bipolar (Lewandowski et al, 2011;Sørensen et al, 2012) and has been shown to precede the onset of psychosis by an average of nine years (Van Oel et al, 2002), causing some to argue that early cognitive decline is a hallmark feature of schizophrenia (see Kahn and Keefe, 2013).…”

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

“…Visual memory, verbal learning, attention, working memory, executive function and social cognition are common cognitive domains impaired in FEP compared to the performance of healthy controls (Bora et al, 2014, Aas et al, 2014, Üçok et al, 2013. It is important to elucidate the trajectory of cognitive dysfunction following an initial psychotic episode, and any clinical or biological determinants of such progression, which can only be established by longitudinal studies of cognitive function.…”