Cognitive deficit is correlated with sleep stability in insomnia: A cardiopulmonary coupling study

Zhang, Xuan; Song, Bingxin; Liu, Yanyan; Wan, Yahui; Zhou, Kai; Xue, Rong

doi:10.1002/brb3.2068

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…They found increased LFC and a lower HFC/LFC ratio among the insomnia group ( Schramm et al, 2013 ). Zhang et al (2021) studied insomnia patients with cognitive impairment and found decreased HFC indicating predominance of unstable sleep compared to insomnia patients with normal cognition. However, Jarrin et al (2016) found that improvements in some sleep parameters in insomnia patients subjected to 6 weeks of cognitive behavior therapy was associated with decreased HFC.…”

Section: Cardiopulmonary Coupling In Other Sleep Disordersmentioning

confidence: 99%

Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease

Ashry

Thomas

2021

Front. Neurosci.

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The interactions of heart rate variability and respiratory rate and tidal volume fluctuations provide key information about normal and abnormal sleep. A set of metrics can be computed by analysis of coupling and coherence of these signals, cardiopulmonary coupling (CPC). There are several forms of CPC, which may provide information about normal sleep physiology, and pathological sleep states ranging from insomnia to sleep apnea and hypertension. As CPC may be computed from reduced or limited signals such as the electrocardiogram or photoplethysmogram (PPG) vs. full polysomnography, wide application including in wearable and non-contact devices is possible. When computed from PPG, which may be acquired from oximetry alone, an automated apnea hypopnea index derived from CPC-oximetry can be calculated. Sleep profiling using CPC demonstrates the impact of stable and unstable sleep on insomnia (exaggerated variability), hypertension (unstable sleep as risk factor), improved glucose handling (associated with stable sleep), drug effects (benzodiazepines increase sleep stability), sleep apnea phenotypes (obstructive vs. central sleep apnea), sleep fragmentations due to psychiatric disorders (increased unstable sleep in depression).

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Section: Cardiopulmonary Coupling In Other Sleep Disordersmentioning

confidence: 99%

Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease

Ashry

Thomas

2021

Front. Neurosci.

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“…The pathogenesis may be related to increased sympathetic activity, dysregulation of the hypothalamic-pituitary axis, and increased inflammation ( Javaheri and Redline, 2017 ). Moreover, insomnia is considered a risk factor for HTN ( Cappuccio and Miller, 2017 ; Bathgate and Fernandez-Mendoza, 2018 ), cognitive impairment ( Irwin and Vitiello, 2019 ; Zhang et al, 2021 ), obesity, and diabetes ( Knutson et al, 2017 ; Mokhlesi et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation

et al. 2022

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Insomnia, whether chronic or intermittent, is a common central nervous system disease. Ciwujia Tablet (CWT) is a well-known traditional Chinese medicine (TCM) made from the extract of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. This medication is commonly used for treating insomnia in China, but the lack of in-depth research focused on the chemical ingredients of CWT creates a gap in knowledge regarding its effective constituents against insomnia. Considering that the therapeutic material basis, targets, and pathways related to this drug have not been fully investigated by scholars in the field, the focus of this study is on identifying the chemical ingredients or structural characteristics of CWT by the UPLC-Q-TOF-MS/MS technique. Besides, concepts of network pharmacology were also used to investigate the targets and pathways of CWT. An insomnia rat model was established by intraperitoneal injection of p-chlorophenylalanine, and the results were verified through various experiments. A total of 46 ingredients were identified in CWT, such as eleutheroside B, eleutheroside E, isofraxidin, and chlorogenic acid. Among them, 17 ingredients with good solubility, favorable gastrointestinal absorption, and high bioavailability were selected for network pharmacological analysis. It was concluded that CWT participated in the regulation of neurotransmitter levels, modulation of ion transport, neurotransmitter receptor activity, synaptic transmission, dopaminergic transmission and other essential processes. Results from the animal experiments showed that CWT can increase the content of inhibitory neurotransmitters 5-HT and GABA in the brain, reduce the synthesis of excitatory escalating transmitters DA and NE, shorten the sleep latency and prolong the sleep duration of insomnia rats. Furthermore, CWT could significantly alleviate the symptoms of insomnia in model rats. Identifying the chemical ingredients of CWT in this experiment is of great significance for exploring its potential curative effects, which provides a solid basis for further understanding the therapeutic value of this medication.

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Cardiopulmonary Coupling

Penzel

Thomas

2022

Advances in the Diagnosis and Treatment of Sleep Apnea

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Cognitive deficit is correlated with sleep stability in insomnia: A cardiopulmonary coupling study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 35 publications

Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease

Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease

Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation

Cardiopulmonary Coupling

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