Cognitive decline in moyamoya: influence of chronic cerebral hypoxia, history of stroke, or comorbid conditions?

Kossorotoff, Manoëlle

doi:10.1111/j.1469-8749.2011.04159.x

Cited by 13 publications

(9 citation statements)

References 5 publications

(17 reference statements)

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“…7,26,31 However, some researchers have suggested that there are other relevant risk factors or comorbid conditions that lead to dysexecutive syndrome, such as clinical stroke history, bilateral or unilateral disease, and younger age at onset. 16,20,33 Therefore, a study of dysexecutive syndrome in different clinical MMD subtypes is warranted. Hence, in the current study, we aimed to determine which aspects of executive function are impaired in patients with MMD compared with healthy controls, and to identify the clinical subtypes and mechanisms underlying dysexecutive function in these patients.…”

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confidence: 99%

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes

Fang

Hua

Zhang

et al. 2016

JNS

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obJective Dysexecutive syndrome is common in patients with moyamoya disease (MMD), a chronic cerebrovascular disease that is characterized by stenosis of the bilateral internal carotid arteries and progressive collateral revascularization, and MMD can be classified as ischemic or hemorrhagic according to the disease presentation and history. In this study, the authors aimed to determine which aspects of executive function are impaired in patients with MMD, in addition to the specific dysexecutive functions present among its clinical subtypes and the mechanisms underlying dysexecutive function in these patients. [SART]) to 49 patients with MMD and 47 IQ-, age-, education-, and social status-matched healthy controls. The dysexecutive questionnaire (DEX) was also used to assess participants' subjective feelings about their executive function. A total of 39 of the patients were evaluated by CT perfusion (CTP) before the assessments were performed, and the correlations among the performances of the patients on the above tests with the parameters of cerebral blood volume, cerebral blood flow (CBF), mean transit time (MTT), and time-to-peak (TTP) in the frontal lobes of these patients were also analyzed. results Many aspects of executive function in the patients with MMD were significantly poorer than those in the healthy controls, and the patients performed particularly poorer on the VF test, HSCT, N-back test, and SART. The patients with hemorrhagic MMD exhibited worse executive inhibition, executive processing, and semantic inhibition compared with those with ischemic MMD, but the latter group presented a worse working memory and poorer sustained attention. There were no significant differences in the DEX scores between the patients with MMD and healthy controls. The other findings were as follows: CBF was significantly positively correlated with the number correct on part B of the HSCT (r = 0.481, p = 0.01) and accuracy on the 0-back task of the N-back (r = 0.346, p = 0.031); MTT was significantly positively correlated with accuracy on the 2-back task of the N-back (r = 0.349, p = 0.034) and factor 5 of the DEX (r = 0.359, p = 0.032); and TTP was significantly positively correlated with the number correct on part B of the HSCT (r = 0.402, p = 0.034) and the 1-back reaction time of the N-back (r = 0.356, p = 0.026). coNclusioNs The patients with MMD exhibited impairments in semantic inhibition, executive processing, working memory, and sustained attention, but they were not aware of these deficits. Moreover, differences in dysexecutive function existed between the different subtypes of MMD. Hypoperfusion of the frontal lobe may be related to working memory and semantic inhibition impairments in patients with MMD.

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confidence: 99%

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes

Fang

Hua

Zhang

et al. 2016

JNS

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“…She also had intellectual disability, attributed to the deleterious effect of chronic cerebral hypoxia in MMD. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Morning glory disc anomaly and facial hemangiomas in a girl with moyamoya syndrome

Sathyan

Chackochan

2018

Indian J Ophthalmol

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Moyamoya disease (MMD) is a chronic progressive, occlusive cerebrovascular disease in the circle of Willis and the feeding arteries. Morning glory disc anomaly (MGDA) is characterized by an abnormal excavated optic disc with radial emergence of blood vessels from the rim of the disc. We describe a case of moyamoya syndrome (MMS), a rare entity among Indian ethnicity, associated with MGDA and regressed facial capillary hemangiomas, which are relatively less reported presentations of MMD. This report emphasizes on the role of neuroimaging in MGDA, so as to facilitate early detection and management of life-threatening intracranial pathologies such as MMS.

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“…8,42 Disease bilaterality and duration of symptoms were the main factors associated with cognitive deficits, whereas age was not. 43 The role of a detrimental diffuse and prolonged ischemic-hypoxic mechanism in cognitive effects, similar to vascular cognitive impairment demonstrated in other brain hypoperfusion conditions in adults, has been suggested. 44 Our patient presenting with cognitive decline was found to have bilateral disease.…”

Section: Clinical Profilementioning

confidence: 99%

Clinicoradiological Profile of Childhood Moyamoya Disease: Indian Study of 30 Children with Literature Review

Lahoti¹,

Ray²

2018

Indian Journal of Physical Medicine and Rehabilitation

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Cognitive decline in moyamoya: influence of chronic cerebral hypoxia, history of stroke, or comorbid conditions?

Cited by 13 publications

References 5 publications

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes

Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes

Morning glory disc anomaly and facial hemangiomas in a girl with moyamoya syndrome

Clinicoradiological Profile of Childhood Moyamoya Disease: Indian Study of 30 Children with Literature Review

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