Cognitive Behavior in Heredodegenerative Ataxias

Botez-Marquard, T; Botez, M.I.

doi:10.1159/000116970

Cited by 80 publications

(29 citation statements)

References 22 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The remarkable result regarding perseverative errors was found after cerebellar rTMS when the new sequence had to be detected and after DLPFC rTMS when both sequences were performed. Perseverations are distinctive symptoms linked to prefrontal dysfunction (Hauser, 1999), and interestingly, they are also elicited by cerebellar damage (Mandolesi, Leggio, Graziano, Neri, & Petrosini, 2001;Schmahmann & Sherman, 1997;Botez-Marquard & Botez, 1993). This finding is in line with the view that cerebellar lesions might provoke ''frontal-like'' cognitive deficits, supported by clinical reports of severe problems in initiation/perseveration and cognitive planning in cerebellar patients (Hauser, 1999;Schmahmann & Sherman, 1997;Appollonio, Grafman, Schwartz, Massaquoi, & Hallett, 1993;Grafman et al, 1992;el-Awar et al, 1991).…”

Section: Discussionsupporting

confidence: 77%

The What and How of Observational Learning

Torriero

Oliveri

Koch

et al. 2007

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

Abstract& Neuroimaging evidence increasingly supports the hypothesis that the same neural structures subserve the execution, imagination, and observation of actions. We used repetitive transcranial magnetic stimulation (rTMS) to investigate the specific roles of cerebellum and dorsolateral prefrontal cortex (DLPFC) in observational learning of a visuomotor task. Subjects observed an actor detecting a hidden sequence in a matrix and then performed the task detecting either the previously observed sequence or a new one. rTMS applied over the cerebellum before the observational training interfered with performance of the new sequence, whereas rTMS applied over the DLPFC interfered with performance of the previously observed one. When rTMS applied over cerebellar or prefrontal site was delivered after the observational training, no influence was observed on the execution of the task. These results furnish new insights on the neural circuitry involved in the single component of observational learning and allow us to hypothesize that cerebellum and DLPFC interact in planning actions, the former by permitting the acquisition of procedural competencies and the latter by providing flexibility among already acquired solutions. &

show abstract

Section: Discussionsupporting

confidence: 77%

The What and How of Observational Learning

Torriero

Oliveri

Koch

et al. 2007

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

show abstract

“…Slowed information processing is the only feature consistently reported by the limited number of studies addressing cognitive function in FRDA [2,3,22,23,54,55]. Most researchers acknowledge the confounding effect of the motor impairment associated with FRDA on general reaction time tasks, and the difficulty in isolating cognitive function in tasks that require a motor response.…”

Section: Introductionmentioning

confidence: 99%

Impairment in motor reprogramming in Friedreich ataxia reflecting possible cerebellar dysfunction

et al. 2009

View full text Add to dashboard Cite

The cerebellar and spinocerebellar dysfunction seen in Friedreich ataxia (FRDA) has known effects on motor function. Recently, it was suggested that people with FRDA may also have impairment in motor planning, either because of cortical pathology or because of cerebello-cortical projections. Fifteen adults with FRDA and 15 matched controls completed a task requiring reciprocating movements between two buttons on a tapping board. Occasionally there was one of three "oddball" stimuli requiring reprogramming of movement. These were change in (1) direction, (2) extent or (3) direction and extent. We hypothesized that people with FRDA would have prolonged movement times due to their movement disorder, and that changes in preparation time would be affected in a way similar to controls, unless there was impairment in motor planning in FRDA. Movement execution and, to a lesser degree, movement preparation were impaired in individuals with FRDA. We argue this points to disturbed cortical function. There was a significant negative correlation between age of onset and all three reprogramming conditions, suggesting an impact of FRDA on developing motor planning. Future studies will be required to establish whether this dysfunction is due to cerebellar impairment interrupting cerebro-ponto-cerebello-thalamo-cerebral loops, primary cortical pathology or a combination of the two.

show abstract

“…Botez, Gravel, Attig, and Vézina (1985) first underscored the role of cerebellofrontal and cerebelloparietal associative loops as neural substrates of mild frontal-and parietal-like symptoms encountered in a patient with reversible cerebellar ataxia after chronic phenytoin intoxication. Many of their subsequent studies further explored the role of the cerebellum in visuospatial and visuoconstructive procedures (Botez, Léveillé, Lambert, & Botez, 1991;Botez-Marquard & Botez, 1993;Botez-Marquard, Léveillé, & Botez, 1994;Botez-Marquard & Routhier, 1995;Botez-Marquard, Pedraza, & Botez, 1996). Closely related to the view that the cerebellum participates in visuospatial functions, Molinari (1997, 1999) reported a patient with cerebellar atrophy who showed typical features of spatial or afferent dysgraphia.…”

mentioning

confidence: 99%