The Lateralized Linguistic Cerebellum: A Review and a New Hypothesis

Mariën, Peter; Engelborghs, Sebastiaan; Fabbro, Franco; Deyn, Peter Paul De

doi:10.1006/brln.2001.2569

Cited by 301 publications

(209 citation statements)

References 123 publications

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“…During the last century, the conception of the cerebellum has progressively evolved from that of a pure motor control device to that of a modulator of the cognitive functions tied to any area in cortex to which it is reciprocally connected (e.g., Andreasen & Pierson, 2008;Mariën et al, 2001;Stoodley & Schmahmann, 2010). The cerebellum has reciprocal links through pontine and dentate nuclei and thalamus mainly to frontal and association areas of the cerebral cortex (e.g., Mariën & Manto, 2015).…”

Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

“…The cerebellum has reciprocal links through pontine and dentate nuclei and thalamus mainly to frontal and association areas of the cerebral cortex (e.g., Mariën & Manto, 2015). These links include not only frontal motor areas, but also language-related areas such as Broca's region (Desmond et al, 2005;Mariën et al, 2001). As highlighted by Murdoch (2010), "this reciprocal connectivity forms a series of segregated neural loops that are hypothesized to facilitate linguistic function in the same way that the cerebellum enhances motor functions (Leiner et al, 1989).…”

Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

“…Several authors have argued that language processing is mostly confined to the right cerebellum (e.g., Stoodley & Schahmann, 2010;Mariën et al, 2001). Anatomically, projections between the The Cerebellum and Self-monitoring in Language Production 5 cerebral and cerebellar cortices are largely (though not exclusively) contralateral (e.g., Brodal, 1979).…”

Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

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Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Runnqvist

Bonnard

Gauvin

et al. 2016

Cortex

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Some language processing theories propose that, just as for other somatic actions, self-monitoring of language production is achieved through internal modeling. The cerebellum is the proposed center of such internal modeling in motor control, and the right cerebellum has been linked to an increasing number of language functions, including predictive processing during comprehension.Relating these findings, we tested whether the right posterior cerebellum has a causal role for self-monitoring of speech errors. Participants received 1Hz repetitive transcranial magnetic stimulation during 15 minutes to lobules Crus I and II in the right hemisphere, and, in counterbalanced orders, to the contralateral area in the left cerebellar hemisphere (control) in order to induce a temporary inactivation of one of these zones. Immediately afterwards, they engaged in a speech production task priming the production of speech errors.Language production was impaired after right compared to left hemisphere stimulation, a finding that provides evidence for a causal role of the cerebellum during language production. We interpreted this role in terms of internal modeling of upcoming speech through a verbal working memory process used to prevent errors.

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Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

Section: Functional Topography Of the Cerebellummentioning

confidence: 99%

See 1 more Smart Citation

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Runnqvist

Bonnard

Gauvin

et al. 2016

Cortex

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“…Notwithstanding, increased cerebellar activation was reported during movement imagination [Decety et al, 1994;Jueptner et al, 1997], preparation [Deiber et al, 1996;Krams et al, 1998], and observation with the aim to imitate [Grèzes et al, , 1999, although the highest activations are usually found during actual movement execution [Deiber et al, 1996;Jueptner et al, 1997;Krams et al, 1998]. Cerebellum plays also a significant role in the early phases of acquisition and planning of motor sequences [Doyon et al, 2002], and is known to participate in a wide variety of cognitive and emotional processes [e.g., see Marien et al, 2001;Middleton and Strick, 1998;Rapoport et al, 2000;Salman, 2002]. Moreover, a modular organization of internal models of tool manipulation has been recently reported in the cerebellum using fMRI [Imamizu et al, 2003], extending the predictions of the MOSAIC computational model [Haruno et al, 2001;Wolpert and Kawato, 1998] from to the "motor" to the "cognitive" cerebellum.…”

Section: Innervatory Patternsmentioning

confidence: 99%

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Peigneux

Linden

Garraux

et al. 2004

Human Brain Mapping

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Abstract:The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychological model for upper limb apraxia [Rothi LJ, et al. The Neuropsychology of Action. 1997. Hove, UK: Psychology Press]. Regional cerebral blood flow was measured in healthy volunteers using H 2 15O PET during performance of four tasks commonly used for testing upper limb apraxia, i.e., pantomime of familiar gestures on verbal command, imitation of familiar gestures, imitation of novel gestures, and an action-semantic task that consisted in matching objects for functional use. We also re-analysed data from a previous PET study in which we investigated the neural basis of the visual analysis of gestures. First, we found that two sets of discrete brain areas are predominantly engaged in the imitation of familiar and novel gestures, respectively. Segregated brain activation for novel gesture imitation concur with neuropsychological reports to support the hypothesis that knowledge about the organization of the human body mediates the transition from visual perception to motor execution when imitating novel gestures [Goldenberg Neuropsychologia 1995;33:63-72]. Second, conjunction analyses revealed distinctive neural bases for most of the gesture-specific cognitive processes proposed in this cognitive model of upper limb apraxia. However, a functional analysis of brain imaging data suggested that one single memory store may be used for "to-be-perceived" and "to-be-produced" gestural representations, departing from Rothi et al.'s proposal. Based on the above considerations, we suggest and discuss a revised model for upper limb apraxia that might best account for both brain imaging findings and neuropsychological dissociations reported in the apraxia literature.

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“…However as mentioned previously, work with cortical patients suggest that speech dyspraxia is more likely to be related to articulatory rehearsal problems than is speech dysarthria (Baddeley & Wilson, 1985;Bishop & Robson, 1989;Waters et al, 1992;Goerlich et al, 1995). Further, there is a growing consensus that the cerebellum contributes to components of language other than overt and covert articulation (for reviews see Mariën et al, 2001;Justus & Ivry, 2001), and it is not implausible that its contribution to verbal working memory could relate to phonological shortterm storage instead of or in addition to articulatory rehearsal. The current studies add to the case for a non-articulatory role for the cerebellum, and, if one is partial to the Baddeley-Hitch model, suggest consideration of how the cerebellum may be a component of both the phonological and articulatory sides of speech.…”

mentioning

confidence: 96%

Reduced phonological similarity effects in patients with damage to the cerebellum

et al. 2005

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Ten cerebellar patients were compared to ten control subjects on a verbal working memory task in which the phonological similarity of the words to be remembered and their modality of presentation were manipulated. Cerebellar patients demonstrated a reduction of the phonological similarity effect relative to controls. Further, this reduction did not depend systematically upon the presentation modality. These results first document that qualitative differences in verbal working memory may be observed following cerebellar damage, indicating altered cognitive processing, even though behavioral output as measured by the digit span may be within normal limits. However, the results also present problems for the hypothesis that the cerebellar role is specifically associated with articulatory rehearsal as conceptualized in the Baddeley-Hitch model of working memory. Keywordscerebellum; verbal working memory; speech perception; language; cognition; short-term memory; dysarthria; aphasia Researchers in cognitive neuroscience have in many cases looked to converging data from multiple methodologies when investigating a cognitive process of interest. The complementary perspectives of functional neuroimaging and cognitive neuropsychology are often employed in this regard; a strong case can be made for the involvement of a brain region in a given cognitive process when it is both metabolically active when healthy participants engage in the cognitive process, and when damage to this region disrupts the same cognitive process. Although the precise nature of this involvement may prove elusive to characterize, the brain region comes to be regarded as an essential component of the system in question. When the two methodologies of neuroimaging and neuropsychology do not converge, however, even the most basic question of whether a given region is involved in a cognitive process is difficult to address.One issue that must be kept in mind when making comparisons between data from neuroimaging and data from neuropsychology is that the two methods provide very different kinds of evidence about cognition. Neuroimaging studies have the potential to document qualitative aspects of cognitive processing that may not be evident from the behavioral outcome. In contrast, neuropsychological data -particularly that from standardized batteries that examine for gross impairment across a wide range of cognitive tasks -sometimes do not NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript allow for such an observation. Identical behavioral outcomes may become falsely equated with identical cognitive processes, when this most certainly is not always the case. 1 Neuropsychological studies must be designed such that the relevant qualitative as well as quantitative differences in a cognitive process may be observed.A relative lack of convergence in the neuroimaging and neuropsychological literatures was a part of the motivation for the current study, which investigated the verbal working memory abilities of patients with damage...

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The Lateralized Linguistic Cerebellum: A Review and a New Hypothesis

Cited by 301 publications

References 123 publications

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Reduced phonological similarity effects in patients with damage to the cerebellum

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