Cognitive and physical measures in rehabilitation of patients with lupus

Bleiberg, Joseph; Bunning, Robert D.

doi:10.1097/00002281-199809000-00008

Cited by 7 publications

(6 citation statements)

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“…Finally, we found no relationship between SLE activity and cognitive impairment, in agreement with previous studies, 37 although a detailed psychometric analysis was not carried out in our patients. Recently, several longitudinal studies have evaluated the cognitive impairment in SLE 38,39 and their relationship with anticardiolipin antibodies. 40,41 When we evaluated the impact of acute episodes on quality of life in our SLE patients, pain seemed to be the most important factor in impairing general functioning and occupational activity, since there were no signi®cant changes in physical disability between the two evaluations.…”

Section: Discussionmentioning

confidence: 99%

Psychiatric and psychosocial disorders in patients with systemic lupus erythematosus: a longitudinal study of active and inactive stages of the disease

Seguí

Ramos‐Casals²,

Garcı́a-Carrasco

et al. 2000

Lupus

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The objective was to analyze psychiatric disorders and psychosocial dysfunction in patients with systemic lupus erythematosus (SLE), studied longitudinally during active and subsequent inactive stage of their disease. During a 6 month period of study, we selected 20 consecutive patients with SLE who presented with a SLE flare. All patients fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. When patients entered the study, we performed psychiatric (CIS, RDC, STAI, HD, BDI, GHQ and MMS) psychosocial (GAS and VAS-P) scores assessment. One year later, we repeated the psychiatric and psychosocial assessment when patients showed inactive disease. The 20 patients evaluated were women, with a mean age of 34 y (SE 14.4, range 20-57). According to CIS evaluation, we diagnosed 8 (40%) psychiatric cases in the acute episode of SLE. The RDC diagnosis showed generalized anxiety in 5 patients, panic disorders in 2 patients and generalized anxiety plus depressive symptoms in one patient. One year later, when patients did not show disease activity, we diagnosed 2 (10%) psychiatric cases (P<0.05). When SLE patients were clinically inactive, they showed lower levels of psychological distress (GHQ scale, 1.8 vs 5.6, P<0.001), with a lower grade of anxiety measured by both HA (3.2 vs 8.2, P<0.01) and STAI-S (7.95 vs 20.90, P<0.001) scales. We also found a lower score in pain perception (VAS-P) (2.80 vs 4.25, P<0. 01) and higher occupational activity (VAS-P) (83.9 vs 66.2, P<0.01) and general functioning (GAS) (93.75 vs 83.50, P<0.05) during the inactive stage. No significant differences were found when we compared cognitive impairment, grade of depression and physical disability between inactive and active stages. We conclude that in SLE patients, psychiatric and psychosocial disorders during acute episodes are usually mild and seem to be related to the psychological impact of disease activity on patients. This type of psychiatric pathology is similar to that which would be expected in other groups coping with a stressful event, indicating that our patients did not react in a way specifically determined by their systemic disease.

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Section: Discussionmentioning

confidence: 99%

Psychiatric and psychosocial disorders in patients with systemic lupus erythematosus: a longitudinal study of active and inactive stages of the disease

Seguí

Ramos‐Casals²,

Garcı́a-Carrasco

et al. 2000

Lupus

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“…The Automated Neuropsychological Assessment Metrics (ANAM) system (96) has utility in screening for cognitive dysfunction in pediatric and adult SLE patients (97)(98)(99)(100). The ANAM subtests have strong correlations with traditional paper screening tasks such as the Trail Making Test, the Stroop Color Word Test, and the Digit Symbol Test (96,100) but do not examine complex aspects of memory, language, and visuospatial functions.…”

Section: Cognitive Assessment Of Patients With Slementioning

confidence: 99%

Cognitive dysfunction in systemic lupus erythematosus: Past, present, and future

Kozora¹,

Hanly²,

Lapteva³

et al. 2008

Arthritis & Rheumatism

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“…The Automated Neuropsychological Assessment Metrics (ANAM) system (96) has utility in screening for cognitive dysfunction in pediatric and adult SLE patients (97–100). The ANAM subtests have strong correlations with traditional paper screening tasks such as the Trail Making Test, the Stroop Color Word Test, and the Digit Symbol Test (96, 100) but do not examine complex aspects of memory, language, and visuospatial functions. The ANAM system is subject to practice effects (101, 102); it has limited sensitivity and may not be able to detect some of the changes in cognitive functioning in SLE patients.…”

Section: Cognitive Assessment Of Patients With Slementioning

confidence: 99%

Mammary serine protease inhibitor inhibits epithelial growth factor‐induced epithelial‐mesenchymal transition of esophageal carcinoma cells

Zhang¹,

Zhou²,

Lei³

et al. 2008

Cancer

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BACKGROUND:By using proteomic technology, the authors previously observed the substantial down‐regulation of mammary serine protease inhibitor (maspin) in esophageal squamous cell carcinoma and metastases. In the current study, they examined the effects of maspin re‐expression in a maspin‐null esophageal cancer cell line EC109 and also investigated the underlying mechanism.METHODS:A cell line with stable maspin expression was established. An epithelial growth factor (EGF)‐induced epithelial‐mesenchymal transition (EMT) model was used to mimic some aspects of the metastatic process in vitro. The effects of maspin reintroduction on EGF‐induced EMT and cell growth characteristics were evaluated. Comparative proteomic analysis of transfected cells versus parental cells was then performed to explore the potential mechanism.RESULTS:The introduction of maspin into EC109 cells was able to inhibit EGF‐induced EMT and altered cell growth characteristics, including the serum dependence, proliferative response to EGF stimulation, and colony formation ability in soft agar, indicating a conversion from a malignant phenotype to a benign phenotype. Proteomic analysis revealed a significant down‐regulation of a group of glycolytic enzymes in maspin‐transfected cells. In addition, maspin‐transfected cells expressed much lower levels of hypoxia‐inducible factor 1α than parental cells or empty vector transfected cells.CONCLUSIONS:Maspin exhibited a metastasis‐suppressive effect, which may be a consequence of the reversal of the malignant phenotype of EC109 cells. The switch of cellular metabolic phenotype to low glycolysis by the gain of maspin function may play a key role in the process. This finding provides additional evidence of the tumor metastasis‐suppressive activity of maspin and may indicate a new direction for future studies of the mechanism of maspin. Cancer 2009. © 2008 American Cancer Society.

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Cognitive and physical measures in rehabilitation of patients with lupus

Cited by 7 publications

References 0 publications

Psychiatric and psychosocial disorders in patients with systemic lupus erythematosus: a longitudinal study of active and inactive stages of the disease

Psychiatric and psychosocial disorders in patients with systemic lupus erythematosus: a longitudinal study of active and inactive stages of the disease

Cognitive dysfunction in systemic lupus erythematosus: Past, present, and future

Mammary serine protease inhibitor inhibits epithelial growth factor‐induced epithelial‐mesenchymal transition of esophageal carcinoma cells

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