Cognitive and motor functioning in patients with multiple sclerosis: Neuropsychological predictors of walking speed and falls

D'Orio, Vanessa L.; Foley, Frederick W.; Armentano, Francine; Picone, Mary Ann; Kim, Sonya; Holtzer, Roee

doi:10.1016/j.jns.2012.02.003

Cited by 111 publications

(93 citation statements)

References 60 publications

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“…Persons with MS have worse walking 1 and cognitive 2 performance than controls without MS, and there is evidence that these performance deficits are interrelated, 3,4 perhaps based on co-occurring damage in neural regions that are important for both functions. 5 If these tasks are associated based on similar neural regions, then it may be difficult to simultaneously perform well in these spheres of neurobehavioral function.…”

mentioning

confidence: 99%

Nonsignificant Associations Between Measures of Inhibitory Control and Walking While Thinking in Persons With Multiple Sclerosis

Sandroff

Benedict

Motl

2015

Archives of Physical Medicine and Rehabilitation

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mentioning

confidence: 99%

Nonsignificant Associations Between Measures of Inhibitory Control and Walking While Thinking in Persons With Multiple Sclerosis

Sandroff

Benedict

Motl

2015

Archives of Physical Medicine and Rehabilitation

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“…11 Several studies have investigated the factors relating to falls in people with MS. The factors that are most common are deficits of balance (7 studies), 1,2,4,[12][13][14][15] walking aid use and lower mobility status (6 studies 2,5,12,14,16,17 ), and a higher Expanded Disability Status Score (6 studies 4,5,10,13,14,17 ). Other authors have found that impairments of muscle tone and proprioception, 5 continence, 1 brainstem and middle cerebellar peduncal lesions, 13 and increasing numbers of symptoms 16 are associated with falls.…”

mentioning

confidence: 99%

Falls in People With Multiple Sclerosis Who Use a Walking Aid: Prevalence, Factors, and Effect of Strength and Balance Interventions

Coote

Hogan

Franklin

2013

Archives of Physical Medicine and Rehabilitation

104

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“…It is known that MS is associated with a wide range of cognitive problems. 23 Several cognitive domains including verbal memory 24 and cognitive processing speed 25 are associated with the frequency of prior falls, and executive function has been associated with the frequency of future falls. 26 There are also data linking the interaction between impairments of cognition and walking to fall risk in people with MS, 27 although others have not found this association.…”

Section: People With Varied Levels Of Cognitive Ability Should Be Incmentioning

confidence: 99%

Whom to Target for Falls-Prevention Trials

Cameron¹,

Coote²,

Sosnoff³

2014

International Journal of MS Care

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Multiple sclerosis (MS) is a chronic neurologic disease that may cause impairments in cognition, muscle strength, muscle tone, sensation, coordination, balance, and gait, all of which are associated with an increased risk of falls.1-7 A number of studies also demonstrate that people with MS fall frequently 1,3,5,6,[8][9][10][11][12] and fall significantly more often than healthy people of the same age and gender.11,13 Over 50% of people with MS fall in a 3-to 6-month period, and around 30% to 50% fall multiple times. 3,[5][6][7]9,10 People with MS also often sustain fallrelated injuries. 6,8,11,14 Falls in people with MS are also associated with reduced balance confidence, 15 social isolation, and reduced participation in occupational and leisure activities. 16,17 Although the cross-sectional data do not clarify the direction of these associations, it is theorized that falling likely contributes to reduced balance confidence, socialization, and participation in activities. Given the high frequency of falls in people with MS and the significant impact of these falls on people's lives, effective falls-prevention approaches are needed. MethodsThe International MS Falls Prevention Research Network (IMSFPRN) was established to help meet the need to develop and evaluate falls-prevention approaches for people with MS. The IMSFPRN held its inaugural meeting in March 2014 in Kingston, Ontario, Canada, to develop a falls-prevention intervention research protocol that could be executed at multiple sites. This meeting was attended by a multidisciplinary group of MS researchers, providers, patients, and representatives from MS support organizations and professional organizations. Different members of the group focused on and presented different specific aspects of trial design for discussion by all members of the group, and each aspect was discussed until consensus was reached. This article, which is derived from the meeting, focuses specifically on whom to include in future trials of MS falls-prevention interventions.

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Cognitive and motor functioning in patients with multiple sclerosis: Neuropsychological predictors of walking speed and falls

Cited by 111 publications

References 60 publications

Nonsignificant Associations Between Measures of Inhibitory Control and Walking While Thinking in Persons With Multiple Sclerosis

Nonsignificant Associations Between Measures of Inhibitory Control and Walking While Thinking in Persons With Multiple Sclerosis

Falls in People With Multiple Sclerosis Who Use a Walking Aid: Prevalence, Factors, and Effect of Strength and Balance Interventions

Whom to Target for Falls-Prevention Trials

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