Cognitive Affective Psychosis Syndrome in a Patient With Sporadic Olivopontocerebellar Atrophy

Duggal, Harpreet S.

doi:10.1176/jnp.17.2.260

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…Similar conditions have been reported in SCA3, 8 and 17 10–12. Recent reports have shown that the parkinsonism features in SCA2 are related to degeneration outside the cerebellum, including substantia nigra and striatum 13 14. These pathology and neuroimaging evidence of degeneration of either presynpatic or postsynaptic dopaminergic system provide bedrocks to explain beneficial treatment effects of levodopa in SCA2 parkinsonism.…”

Section: Discussionsupporting

confidence: 67%

Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2

Chen

Lin²,

Wu³

2012

Case Reports

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Section: Discussionsupporting

confidence: 67%

Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2

Chen

Lin²,

Wu³

2012

Case Reports

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“…In particular, damage to the vermis has been associated with disturbances in emotion regulation (18). Interestingly, the CCAS shares many commonalities with the classical frontal lobe syndrome, which is demonstrated by a patient with sporadic olivopontocerebellar atrophy who displayed behavioural disinhibition and unprovoked laughter (19), disturbances that are not uncommon in patients with frontal damage.…”

Section: Introductionmentioning

confidence: 99%

The cerebellum on the rise in human emotion

2005

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For decennia the cerebellum has largely been excluded from scientific enquiry beyond motor function. However, the intimate afferent and efferent connections to the midbrain and limbic system provide for the neuroanatomical foundation of cerebellar involvement in emotion and emotional disorders. Moreover, an increasing body of empirical evidence indicates that the cerebellum may be involved in emotion regulation. Both functional and structural abnormalities of the cerebellum have been demonstrated in emotional disorders, including depression and schizophrenia. Research shows that the functional repertoire of the cerebellum is broader than previously thought and its involvement in emotion is noteworthy.

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“…Reported psychopharmacological treatments include first-generation and atypical antipsychotics, 5Y7 either alone or combined with lithium 8 or antidepressants. 9 To our knowledge, use of clozapine, indicated for treatment-resistant schizophrenia, 10 has never been reported in refractory psychosis associated with cerebellar pathology, either alone or in combination with valproate.…”

Section: Discussionmentioning

confidence: 99%

Effective Treatment With Clozapine and Valproate for Refractory Schizophrenia-Like Psychosis After Cerebellar Hemorrhage

Almeida¹,

Serrao²,

Almeida³

et al. 2011

Clinical Neuropharmacology

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Background: The cerebellum has traditionally been regarded as an organ of motor coordination. However, the importance of the cerebellum in psychiatric disorders, behavior, and cognition is increasingly being recognized. There is no consensus concerning treatment of schizophrenia-like psychosis after cerebellar pathology. Reports describe the use of several antipsychotics, either alone or in combination with antidepressants or lithium. Clozapine is used for the treatment of refractory schizophrenia, but there are no reports of its use in the abovementioned situation.Case Presentation: We report the case of a 20-year-old woman who developed a schizophrenia-like psychosis after rupture of arteriovenous malformation at 13 years of age. The psychotic symptoms proved to be resistant to treatment, and several psychopharmacological schemas were tried. The clinical picture only showed consistent improvement with the combined use of clozapine and valproate. Conclusions:The relationship between chronic psychosis and cerebellar pathology remains poorly understood. Cases like the present one suggest that clozapine and valproate may be used safely and effectively in refractory schizophrenia-like psychosis associated with cerebellar pathology.

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Cognitive Affective Psychosis Syndrome in a Patient With Sporadic Olivopontocerebellar Atrophy

Cited by 14 publications

References 6 publications

Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2

Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2

The cerebellum on the rise in human emotion

Effective Treatment With Clozapine and Valproate for Refractory Schizophrenia-Like Psychosis After Cerebellar Hemorrhage

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