Cognitive abilities and clinical variables in bipolar I depressed and euthymic patients and controls

Yates, Denise Balem; Dittmann, Sandra; Kapczinski, Flávio; Trentini, Clarissa Marceli

doi:10.1016/j.jpsychires.2010.09.006

Cited by 22 publications

(19 citation statements)

References 84 publications

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“…In this study, subregions of the left orbitofrontal cortex were associated with poor WCST performance, including PPE, PR and NPE, implying an inefficient use of recent contextual information to optimize set shifting [25], reflecting executive dysfunction in euthymic bipolar patients [26,27,28]. The left side lateralization was also in line with previous research showing that left frontal damage might affect WCST performance more than right frontal damage [29].…”

Section: Discussionsupporting

confidence: 88%

“…In our early work, we found that chronic inflammation with significant elevation of serum hs-CRP levels may exist in acute mania, partial remission and full remission [3]. Hence, because CRP is associated with impaired frontal pathways and the corresponding executive function [16], the link between an elevated hs-CRP level and reduced volume of the orbitofrontal cortex may explain the persistent cognitive deficits in euthymic bipolar patients [26,27,28]. …”

Section: Discussionmentioning

confidence: 99%

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The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

Chung

Huang

et al. 2013

Neuropsychobiology

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Objective: C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) levels are linked to the structural volume change of a specific brain region along with cognitive performance. Methods: We recruited 17 physically healthy patients with bipolar I disorder (DSM-IV), aged 18-45 years and euthymic, to undergo the Wisconsin Card Sorting Test (WCST) and volumetric magnetic resonance imaging at 1.5 T. The analytic method was based on the hidden Markov random field model with an expectation-maximization algorithm, and the volume of each brain region was presented as a percentage of the total intracranial volume. Results: Among the various regions, only the orbitofrontal cortex had a significantly negative correlation with serum hs-CRP levels after adjustment for age and gender (left and right orbitofrontal cortex: r = -0.62, p < 0.01, and r = -0.67, p < 0.005, respectively). Regarding cognitive function, poor WCST performance was also associated with certain subregions of the orbitofrontal cortex. Conclusion: Elevation of serum hs-CRP levels, an indicator of inflammation, may be associated with reduced volume of the orbitofrontal cortex. Persistent inflammation in the euthymic phase of bipolar disorder may involve the pathogenesis or pathophysiology of alteration of the frontal pathway.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

Chung

Huang

et al. 2013

Neuropsychobiology

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“…20 of this book (Staging). Overall, the severity of the disease is strongly related to neurocognitive function (Yates et al 2011 ). Onset in childhood or adolescence is related to more severe impairment (Jamrozinski 2010 ).…”

Section: The Effect Of Age and Age At Onset And Personal Psychiatric mentioning

confidence: 99%

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Fountoulakis

2014

Bipolar Disorder

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“…Bipolar depression is commonly associated with fatigue and somnolence (Angst et al 2006 ;Mitchell et al 2001Mitchell et al , 2008Perlis et al 2009) as well as cognitive impairment, with such problems being documented across the bipolar spectrum (Bora et al 2011 ;Solé et al 2011 ;Yates et al 2011). Therefore, stimulants which promote alertness and wakefulness and potentially enhance cognitive function appear to be potential treatment options in bipolar-depressed subjects not responding to first-line treatment (Shelton & Reddy, 2008).…”

Section: Introductionmentioning

confidence: 99%

Use of adjunctive stimulants in adult bipolar depression

Dell’Osso

Ketter

2012

Int. J. Neuropsychopharm.

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Cognitive abilities and clinical variables in bipolar I depressed and euthymic patients and controls

Cited by 22 publications

References 84 publications

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Use of adjunctive stimulants in adult bipolar depression

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