Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats

Bhandarkar, Nikhil S.; Mouatt, Peter; Majzoub, Marwan E.; Thomas, Torsten; Brown, Lindsay; Panchal, Sunil K.

doi:10.3390/pathogens10111369

Cited by 28 publications

(11 citation statements)

References 75 publications

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“…The study found that individuals who lost weight more easily had higher levels of koala bacteria in their gut. In addition to its role in weight loss, this bacterium is a key regulatory factor in maintaining the dynamic balance of intestinal flora [ 46 ]. Therefore, an increase in the relative abundance of its flora may be beneficial.…”

Section: Discussionmentioning

confidence: 99%

Effects of Polymannuronic Acid on the Intestinal Microbiota in Mice after Long-Term Intragastric Administration

Zhang,

Wei,

et al. 2024

Marine Drugs

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Polymannuronic acid (PM) is an alginate oligosaccharide derived from brown algae with a characterized structure and excellent biological activities. Herein, mice were given different doses of PM through 30-day-long-term intragastric administration, and the contents of the jejunum, ileum, and colon were analyzed by 16S rRNA gene sequencing technology for microbial diversity, and relevant experiments were verified according to the analysis results so as to comprehensively evaluate the effects of PM on the intestinal flora. The PM (400 mg/kg and 100 mg/kg) could regulate the microflora balance at the phylum level and increase the microflora richness in the jejunum, ileum, and colon of the mice. The PM could induce more strains that are negatively correlated with Escherichia, thereby reducing the relative abundance of Escherichia. Analysis of bacterial function showed that high and low doses of PM could promote lipid metabolism in the bacterial communities. Moreover, the PM could reduce serum total cholesterol and cholesterol ester levels in a concentration-dependent manner. High-dose PM could lead to colonic intestinal inflammation by increasing the relative abundance of multiple bacterial groups in the jejunum, ileum, and colon. Moreover, high-dose PM could increase lipopolysaccharide-binding protein and interleukin-1β levels. Therefore, the dose of PM plays an important role in its efficacy, and its biological activity is dosedifferent.

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Section: Discussionmentioning

confidence: 99%

Effects of Polymannuronic Acid on the Intestinal Microbiota in Mice after Long-Term Intragastric Administration

Zhang,

Wei,

et al. 2024

Marine Drugs

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“…Coffee husk is one of the carbohydrate and fiber sources (Blinová et al, 2017) with a prebiotic potential that can be absorbed by the host but shows a good effect on microbiota growth in the intestine, such as Lactobacilli and Bifidobacteria, by effectively utilizing feed as the substrate and inducing digestive enzyme secretion, thus increasing gastrointestinal digestion process (Campos et al, 2012;Fiesel et al, 2014;Bhandarkar et al, 2021). This intestinal microflora will produce SCFAs (short-chain fatty acids), namely butyric and propionic acids.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of dietary coffee Coffee canephora husk supplementation on the growth, blood chemicals, and antioxidative activity of red Nile tilapia Oreochromis sp.

Afriansyah¹,

Setiawati²,

Suprayudi³

et al. 2023

Jurnal Akuakultur Indonesia

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Coffee by-products can be used as a feed additive for red Nile tilapia. This study aimed to evaluate the utilization of different dietary coffee husk supplementation dosages on the growth and antioxidative activity of red Nile tilapia (Oreochromis sp.). This study was designed following the completely randomized design experimental method, containing five dietary supplementation treatments, namely P0 (control, 0%), P1 (1%), P2 (2%), P3 (3%), and P4 (4%). Fish were reared for 8 weeks and fed three times a day. Parameters observed contained growth performance and antioxidative activity. The results showed that dietary coffee husk powder supplementation treatments provide higher growth than control treatment. Based on blood chemicals, coffee husk-supplemented diets could enhance the HDL content and reduce cholesterol, triglycerides, and LDL (P<0.05). Superoxide dismutase enzyme was also found higher in coffee husk supplemented diets than in control diet (P<0.05). The MDA level decreased on the coffee husk-supplemented diet treatment and was lower than the control treatment (P<0.05). Dietary supplementation of coffee husk could positively affect liver performance, based on hepatosomatic index and glycogen level. This study concludes that 4% coffee husk in the diet is considered the best treatment to improve the growth and antioxidation level of red Nile tilapia. Keywords: antioxidant, coffee husk, diet, growth, tilapia ABSTRAK Coffee by- product dapat digunakan dalam pakan ikan nila sebagai feed additive. Penelitian ini bertujuan untuk mengevaluasi pemanfaatan tepung kulit dengan dosis berbeda terhadap kinerja pertumbuhan dan antioksidan ikan nila merah (Oreochromis sp.). Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap yang terdiri dari lima perlakuan pakan, yaitu P0 (Kontrol), P1 (1%), P2 (2%), P3 (3%) dan P4 (4%). Pemeliharaan dilakukan selama 60 hari dengan frekuensi pemberian pakan sebanyak 3 kali sehari. Parameter yang diamati adalah kinerja pertumbuhan dan antioksidan. Hasil menunjukkan bahwa pemberian tepung kulit kopi dalam pakan memberikan pertumbuhan yang lebih tinggi dari perlakuan kontrol. Profil biokimia darah menunjukkan bahwa penambahan tepung kulit kopi meningkatkan HDL dan menurunkan kolesterol, trigliserida dan LDL pada ikan yang diberi pakan perlakuan yang mengandung kulit kopi lebih tinggi dibandingkan dengan control (P<0,05). Enzim SOD lebih tinggi pada ikan yang diberi pakan perlakuan kulit kopi dibandingkan control (P<0,05). Kadar MDA menurun pada perlakuan penambahan tepung kulit kopi dan lebih rendah dari perlakuan control (P<0,05). Suplementasi tepung kulit kopi berpengaruh positif terhadap kinerja hati yang ditunjukkan pada nilai indeks hepatosomatik dan glikogen hati. Penelitian ini menyimpulkan bahwa, penggunaan tepung kulit sebesar 4% dalam pakan dianggap paling baik dalam meningkatkan kinerja pertumbuhan dan antioksidan pada ikan nila. Kata kunci: antioksidan, kulit kopi, pakan, pertumbuhan, ikan nila

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“…Thus, the efficacy of coffee cherry pulp juice concentrate in blood lipid control could have potential application in preventing dyslipidemia and other related diseases. Interestingly, some animal studies using coffee pulp aqueous extract (CPE) also showed benefits in modulating glucose intolerance and hyperlipidemia [ 8 , 30 , 31 , 32 ]. The mechanisms of controlling blood sugar and lipids are likely through the inhibition of intestinal cholesterol absorption [ 8 ] and antioxidative effects from polyphenols such as chlorogenic acid (CGA), epicatechin (EC), and catechin [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Twelve-Week Safety and Potential Lipid Control Efficacy of Coffee Cherry Pulp Juice Concentrate in Healthy Volunteers

2023

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Coffee cherry pulp, a major waste product from coffee manufacturing, contains polyphenols with antioxidant activity. However, its clinical safety and health benefits are unclear. This randomized, double-blinded, placebo-controlled trial evaluated the safety and potential efficacy of coffee cherry pulp juice concentrate. A total of 61 participants were randomly divided into a study group (n = 30), receiving the juice, and a control group (n = 31), receiving a placebo drink of 14 g twice daily for 12 weeks. Adverse symptoms, changes in body weight, hematological and biochemical parameters, vital signs, and heart function were evaluated using subject diaries, interviews, blood and urine tests, and electrocardiograms. The results showed no intervention-related adverse events. Body weight, liver, renal function, complete blood counts, blood glucose, urinalysis, and electrocardiograms were not significantly altered throughout the study. Consuming the juice for at least 8 weeks significantly decreased cholesterol and LDL levels. The glucose levels were maintained significantly better than those of the placebo group. The findings suggest that continuously consuming 28 g/day of coffee pulp juice concentrate for 12 weeks is safe in healthy volunteers. Future studies could employ a dose of ≤28 g/day to investigate the efficacy of this novel food, especially for preventing dyslipidemia and diabetes.

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Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats

Cited by 28 publications

References 75 publications

Effects of Polymannuronic Acid on the Intestinal Microbiota in Mice after Long-Term Intragastric Administration

Effects of Polymannuronic Acid on the Intestinal Microbiota in Mice after Long-Term Intragastric Administration

Evaluation of dietary coffee Coffee canephora husk supplementation on the growth, blood chemicals, and antioxidative activity of red Nile tilapia Oreochromis sp.

Twelve-Week Safety and Potential Lipid Control Efficacy of Coffee Cherry Pulp Juice Concentrate in Healthy Volunteers

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