Coffee intake during pregnancy and neonatal low birth weight: data from a multicenter Italian cross sectional study

Mannucci, Carmen; Attard, Everaldo; Calapai, Fabrizio; Facchinetti, Fabio; D’Anna, Rosario; Vannacci, Alfredo; Santamaria, Angelo; Lenti, Maria Carmela; Righi, Maria; Perone, Marcello; Sorbara, Emanuela Elisa; Alibrandi, Angela; Oteri, Alessandro; Inferrera, Giuseppina; Calapai, Gioacchino

doi:10.1080/14767058.2020.1849120

Cited by 7 publications

(13 citation statements)

References 26 publications

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“…Average daily caffeine consumption has been shown to decrease slightly from the first to third trimester of pregnancy: 587 caffeine users with 59.2 ± 61.5 mg/day caffeine intake in the first trimester compared with 577 users (54.3 ± 55.4 mg/day) in the third trimester, respectively. In a study by Mannucci et al [18], which included 5,405 pregnant Italians, it was shown that 42.3% of them reported consuming coffee during pregnancy (70% consumed one cup/day, 23% two cups/day, and 6% at least three cups/day). Differences in the amount of caffeine consumed between Finnish and French and Italian women are most likely due to the general pattern of coffee consumption in these countries.…”

Section: Consuming Coffee During Pregnancy: Recommendations and Realitymentioning

confidence: 99%

“…In a cross-sectional study by Mannucci et al [57], involving 5,405 pregnant Italian women, the effect of coffee consumption during pregnancy on the birth weight of the newborn was assessed. It was shown that newborns of women who consumed ≥ 3 cups of coffee/day during pregnancy were characterized by significantly lower birth weight (OR = 1.566; 95% CI: 1.081-2.267, p = 0.018).…”

Section: Low Birth Weight and Childhood Obesitymentioning

confidence: 99%

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Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Surma

Witek

2022

Ginekol Pol

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Coffee is one of the most consumed beverages in the world. The impact of coffee consumption on human health has been the subject of many clinical studies and meta-analyses. Taking into account the results of these studies, it can be concluded that coffee has a number of health benefits in terms of the population, including the reduction of the risk of death from any cause. From a clinical point of view, the safety of coffee consumption in a specific subpopulation of pregnant women is important. A large percentage of women continue to consume this drink during pregnancy, while a significant proportion of them exceed the permissible daily dose of caffeine (≤ 200 mg). During pregnancy, the metabolism of caffeine slows down significantly, which prolongs its action and penetrates into the body of the fetus. These biochemical observations have become the driving force behind numerous clinical studies assessing the impact of coffee consumption during pregnancy on its course, complications and the health of the newborn. This review article summarizes the current knowledge of these important issues.

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Section: Consuming Coffee During Pregnancy: Recommendations and Realitymentioning

confidence: 99%

Section: Low Birth Weight and Childhood Obesitymentioning

confidence: 99%

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Surma

Witek

2022

Ginekol Pol

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“…Wraz z rozwojem ciąży zmniejsza się matczyny klirens kofeiny, co powoduje zwiększoną ekspozycję płodu na tę substancję, w wyniku czego dochodzi do wydłużenia okresu półtrwania kofeiny. Wzrost ekspozycji płodu na kofeinę może skutkować skurczem naczyń maciczno-łożyskowych i niedotlenieniem płodu, który ze względu na nierozwiniętą w pełni wątrobę i brak enzymu CYP1A2 nie jest w stanie jej metabolizować [1,3,4,5,6,10,11]. Kofeina zwiększa poziom cyklicznego monofosforanu adenozyny w komórkach poprzez hamowanie fosfodiesterazy, co może wpływać na wzrost i rozwój płodu [3].…”

Section: Discussionunclassified

Caffeine maternal intake and its effect on low birth weight of newborns - a literature review

LUCHOWSKA

SROCZYŃSKA

ŻACZEK

2022

J Educ Health Sport

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Introduction: Caffeine consumption during pregnancy is associated with a number of concerns related to fetal development. The daily amount of caffeine consumed has consequences depending on the doses taken.Aim of the study: The purpose of this study is to present the contemporary knowledge on the relationship between prenatal caffeine exposure and its effects on fetal development with special attention to low birth weight of newborns.Materials and methods: PubMed and Google Scholar medical databases were analyzed by typing the following keywords: caffeine, low birth weight, caffeine consumption during pregnancy, cohort studies. During analyzing the literature, data from 14 scientific articles from the last five years (2017-2022) were used.Results: In most of the articles using cohort studies and meta-analyses based on them, the authors emphasize the link between caffeine consumption and low neonatal birth weight and other health implications among children. However, some argue that caffeine consumption does not significantly affect low birth weight in newborns.Conclusions: The results are inconclusive and the study needs to be continued. Most authors confirm the association between caffeine consumption during pregnant and low birth weight while some do not. It seems reasonable to increase awareness among women about the sources of caffeine, the amount of caffeine consumption and the effects on the fetus before conception.

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“…The mechanism by which this occurs is unclear. However, prenatal exposure to cocaine (108,109), methamphetamine (110,111), caffeine (112,113), and nicotine (114,115) are linked to low birth weight. Thus, the cardiovascular effects of these stimulants on the adult offspring may be secondary to low birth weight rather than a direct effect of the drugs on the developing cardiovascular system.…”

Section: Potential Roles Of Common Mechanismsmentioning

confidence: 99%

Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

Rorabaugh

2021

Front. Cardiovasc. Med.

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Prenatal exposure to an adverse uterine environment can have long lasting effects on adult offspring through DNA methylation, histone acetylation, and other epigenetic effects that alter gene expression and physiology. It is well-known that consumption of CNS stimulants such as caffeine, nicotine, amphetamines, and cocaine during pregnancy can adversely impact the offspring. However, most work in this area has focused on neurological and behavioral outcomes and has been limited to assessments in young offspring. The impact of prenatal exposure to these agents on the adult cardiovascular system has received relatively little attention. Evidence from both animal and human studies indicate that exposure to CNS stimulants during the gestational period can negatively impact the adult heart and vasculature, potentially leading to cardiovascular diseases later in life. This review discusses our current understanding of the impact of prenatal exposure to cocaine, methamphetamine, nicotine, and caffeine on the adult cardiovascular system.

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Coffee intake during pregnancy and neonatal low birth weight: data from a multicenter Italian cross sectional study

Cited by 7 publications

References 26 publications

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Caffeine maternal intake and its effect on low birth weight of newborns - a literature review

Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

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