Coffee Intake and obesity

Pimentel, Gustavo D.; Micheletti, Thayana O.; Fernandes, Renata C.; Nehlig, Astrid

doi:10.1016/b978-0-12-816093-0.00024-0

Cited by 5 publications

(3 citation statements)

References 139 publications

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“…The influence of all silverskin extracts (S_LS, S_PS, and S_PS_C) on the intestinal absorption of glucose and fructose was studied. Although several studies report a positive effect of coffee silverskin on intestinal sugar uptake due to the presence of caffeine and CGAs [ 8 , 43 ], as far as we know, this is the first study that assesses the effect of this by-product on the intestinal uptake of both glucose and fructose. Regarding glucose ( 3 H-DG), all the extracts, at the highest concentration tested (1 mg/mL), were able to significantly reduce its uptake by Caco-2 cells ( Figure 4 a–c).…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have already documented that the major bioactive compounds identified and quantified in these extracts by HPLC-DAD (caffeine and CGAs) may act positively on sugar metabolism, namely by inhibiting intestinal glucose transporters [ 7 , 8 , 9 , 16 ]. In order to better understand the results described in Section 3.2 .…”

Section: Resultsmentioning

confidence: 99%

“…Of all the above-mentioned bioactive compounds, several studies have appointed CGAs as some of the major responsible for the positive modulation of coffee on glucose metabolism, particularly (but not only) due to their ability to inhibit intestinal glucose transporters [ 6 , 7 , 8 , 9 ]. The maintenance of glucose homeostasis is, indeed, of crucial importance to human physiology, and the dysregulation of this mechanism is known to be on the basis of metabolic syndrome (MetS) development [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Peixoto

Andrade

Machado

et al. 2022

Foods

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This study investigates the possibility of valorizing coffee silverskin through the recovery of its bioactive compounds using a sustainable extraction method that could be industrially applied. For that, aqueous extracts were prepared using ultrasonic-assisted extraction (laboratorial scale) and, for comparison, a scale-up of the process was developed using the Multi-frequency Multimode Modulated technology. A concentration procedure at the pilot scale was also tested. The three types of extracts obtained were characterized regarding caffeine and chlorogenic acids contents, and the effects on intestinal glucose and fructose uptake (including sugar transporters expression) in human intestinal epithelial (Caco-2) cells were ascertained. The phytochemical contents of the extracts prepared at the laboratory and pilot scale were comparable (caffeine: 27.7 vs. 29.6 mg/g freeze-dried extract; 3-, 4-, and 5-caffeoylquinic acids: 0.19 vs. 0.31, 0.15 vs. 0.42, and 1.04 vs. 1.98 mg/g, respectively; 4- and 5- feruloylquinic acids: 0.39 vs. 0.43 and 1.05 vs. 1.32 mg/g, respectively). Slight differences were noticed according to the extracts preparation steps, but in general, all the extracts promoted significant inhibitions of [1,2-3H(N)]-deoxy-D-glucose and 14C-D-fructose uptake, which resulted mainly from a decrease on the facilitative glucose transporter 2 (GLUT2) and sodium-glucose linked transporter 1 (SGLT1) genes expression but not on the expression of the facilitative glucose transporter 5 (GLUT5) gene. Moreover, a synergistic effect of caffeine and 5-caffeoylquinic acid on sugars uptake was found. The results clearly show that the Multi-frequency Multimode Modulated technology is a viable option to be applied at an industrial level to recover bioactive components from silverskin and obtain extracts with antidiabetic potential that could be used to develop functional food products or dietary supplements.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Peixoto

Andrade

Machado

et al. 2022

Foods

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Anti‐obesity effect of plant diterpenes and their derivatives: A review

Islam

Ali

Mubarak

2020

Phytotherapy Research

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Obesity is a medical condition in which excess body fat is accumulated by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. Obesity increases the risk of various diseases and conditions, including cardiovascular diseases, diabetes, cancer, and depression. This review focuses on most recent reports pertaining to the antiobesity activity of plant-derived diterpenes in different databases. For this, a search (until August 2019) was conducted in the PubMed and Science Direct databases with the following keywords: "plant diterpenes" or "plant diterpenoids" paired with "obesity" or "antiobesity effects." Overall, 729 references that used the aforementioned keywords were selected, among which 34 articles have been included in this review. Results from this search suggest that a number of diterpenes and their derivatives have been found to exert antiobesity effects through various mechanisms, such as overweight reduction or modification of body mass index, protein-tyrosine phosphatase 1B inhibition, lipase activity inhibition, antiadipogenesis effect, among others. Carnosic acid, carnosol and the derivatives of abietic acid, steviol, and andrographolide are examples of important antiobesity diterpenes and their derivatives. Of note, plant-derived diterpenes may be potential candidates for managing obesity and obesity-related diseases and disorders in human and other animals. K E Y W O R D S metabolic diseases, obesity, plant diterpenes

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Higher intakes of dietary caffeine are associated with 25-hydroxyvitamin D deficiency

Chen

Kord‐Varkaneh

Santos

et al. 2022

International Journal for Vitamin and Nutrition Research

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Abstract. Low serum 25-hydroxyvitamin D [25(OH)D] levels remain a challenge worldwide. While some in vitro studies show a caffeine-induced decrease in vitamin D receptor expression, there is a paucity of research to define the extent of caffeine intake on 25(OH)D levels. Therefore, we aimed to associate dietary caffeine intake with 25(OH)D deficiency through a recognized dataset. Using data collected from the 2005–2006 National Health and Nutrition Examination Survey (NHANES), 25(OH)D levels and dietary caffeine intake were extracted from 13134 individuals (30–47 years, interquartile range). We used one-way ANOVA and chi-square tests for quantitative and qualitative variables, respectively, and performed multivariate logistic regression for four models to assess the odds ratio (OR) of 25(OH)D deficiency (<20 ng/ml or <50 nmol/L) based on quartiles of dietary caffeine intake. Both crude and multivariable models detected higher OR for 25(OH)D deficiency according to the highest intakes of caffeine (15.8±9.5, 51.9±11.9, and 177±156 mg/d) when compared to the reference category (2.19±1.04 mg/d), in which the OR in the highest category of caffeine intake was 1.24 (95% CI: 1.12 to 1.37) and 1.48 (95% CI: 1.16 to 1.78) for the crude model and the most complete multivariable analysis (adjustment for age, sex, race, body mass index, smoking, physical activity, occupation, energy intake, protein intake, and fat intake), respectively. In conclusion, higher dietary intakes of caffeine were associated with 25(OH)D deficiency in a representative sample of the American population, but further investigation is warranted to determine causation.

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Coffee Intake and obesity

Cited by 5 publications

References 139 publications

Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Anti‐obesity effect of plant diterpenes and their derivatives: A review

Higher intakes of dietary caffeine are associated with 25-hydroxyvitamin D deficiency

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