Anti‐obesity effect of plant diterpenes and their derivatives: A review

Islam, Muhammad Torequl; Ali, Eunüs S.; Mubarak, Mohammad S.

doi:10.1002/ptr.6602

Cited by 20 publications

(14 citation statements)

References 69 publications

(94 reference statements)

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“…Thus, many terpenoids have important physiological activities and are important sources for developing new drugs from natural plants. For the regulation of lipid modulation in NAFLD or related metabolic diseases, diterpenoids, triterpenoids, and tetraterpenoids, especially retinoids, ginsenoside, carotenoid, glycyrrhizinic acid, lycopene, astaxanthin, and others, such as betulinic acid, ursolic acid, andrographolide, and shizukaol, have been well-studied and reviewed. In recent years, research on monoterpenoids in NAFLD has also gradually become attractive, although studies on these are not popular at present.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases

Zhang

Lin

Cheng

et al. 2022

J. Agric. Food Chem.

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The protective effect of plant active ingredients against non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prominent, and the terpenoids have always been the main active compounds in Chinese herbal medicine exerting hepatoprotective effects. However, the related pharmacological effects, especially for monoterpenoids or iridoid glycosides, which have obvious effects on improvement of NAFLD, have not been systematically analyzed. The objective of this review is to systematically examine the molecular mechanisms of monoterpenoids in NAFLD. The signaling pathways of peroxisome proliferator-activated receptor, insulin, nuclear factor κB, toll-like receptor, adipocytokine, RAC-α serine/threonine protein kinase, mammalian target of rapamycin, 5′-AMP-activated protein kinase, and autophagy have been proven to mediate this protective effect. We further compared the experimental data from animal models, including the dosage of these monoterpenoids in detail, and demonstrated that they are effective and safe candidate drugs for NAFLD. This review provides a reference for the development of NAFLD drugs as well as a research guideline for the potential uses of plant monoterpenoids.

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Section: Introductionmentioning

confidence: 99%

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases

Zhang

Lin

Cheng

et al. 2022

J. Agric. Food Chem.

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“…Several natural products are widely used in obesity treatment (10). Various natural products (11)(12)(13)(14), including flavonoids, alkaloids, and terpenoids control obesity by stimulating lipolysis, inhibiting adipogenesis and lipogenesis, and promoting energy expenditure. However, the activities and mechanisms of natural products in modulating lipolytic activity have not yet been systematically summarized.…”

Section: Introductionmentioning

confidence: 99%

Potential lipolytic regulators derived from natural products as effective approaches to treat obesity

Yang

Jiang³

et al. 2022

Front. Endocrinol.

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Epidemic obesity is contributing to increases in the prevalence of obesity-related metabolic diseases and has, therefore, become an important public health problem. Adipose tissue is a vital energy storage organ that regulates whole-body energy metabolism. Triglyceride degradation in adipocytes is called lipolysis. It is closely tied to obesity and the metabolic disorders associated with it. Various natural products such as flavonoids, alkaloids, and terpenoids regulate lipolysis and can promote weight loss or improve obesity-related metabolic conditions. It is important to identify the specific secondary metabolites that are most effective at reducing weight and the health risks associated with obesity and lipolysis regulation. The aims of this review were to identify, categorize, and clarify the modes of action of a wide diversity of plant secondary metabolites that have demonstrated prophylactic and therapeutic efficacy against obesity by regulating lipolysis. The present review explores the regulatory mechanisms of lipolysis and summarizes the effects and modes of action of various natural products on this process. We propose that the discovery and development of natural product-based lipolysis regulators could diminish the risks associated with obesity and certain metabolic conditions.

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“…Obesity is a complex and chronic disorder influenced by behavioral, genetic and environmental factors [ 1 ]. It is one of the burning issues of public health problems of the running century, affecting all age groups and correlated with oxidative stress that further results in other complications in the form of chronic heart diseases, certain types of cancers (estimated 41% cases), type 2 diabetes (estimated 44% cases), obstructive sleep apnea, osteoarthritis, and psychiatric diseases [ 2 , 3 , 4 , 5 ]. Moreover, obesity is an evolving risk factor for vulnerability and the severity of coronavirus disease 2019 (COVID-19) caused by the acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and it generates alterations in the microbiota and immune responses that are linked with poor virus responses [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

et al. 2022

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Star anise (Illicium verum Hook. fil.) is commonly utilized as a culinary and medicinal fruit and is most famous in indigenous systems of medicine. The present research work aims to appraise and validate the potential of polyphenol-rich star anise tea (SAT) on oxidative stress, obesity and related biochemical parameters in high-fat-sugar-diet (HFSD)-induced obesity model in rats. SAT was prepared using the traditional method in warm water. The Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis was performed for the simultaneous determination of phenolic acids and flavonoids in SAT. Two doses (250 and 500 mg/kg body weight) were selected to investigate the anti-obesity potential of SAT using HFSD-induced obese rat model. Major (>5 mg/100 mL) phenolic acids in SAT were p-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid while catechin and rutin were the major flavonoids detected in the SAT. SAT exhibited 51.3% DPPH radical scavenging activity. In vivo study showed that higher doses of SAT (500 mg/kg body weight) significantly reduced the body weight increase (74.82%) and BMI (0.64 g/cm2). Moreover, significant reductions in the levels of serum total cholesterol, triglyceride, LDL and VLDL were recorded in all the treatment groups in comparison to the HFSDC group. Furthermore, SAT reduced the alterations in MDA, SOD and GSH levels of experimental groups thus showing the potential against oxidative stress. The SAT-500 group showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison to the HFSDC group. The present study proved that SAT exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.

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Anti‐obesity effect of plant diterpenes and their derivatives: A review

Cited by 20 publications

References 69 publications

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases

Potential lipolytic regulators derived from natural products as effective approaches to treat obesity

Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

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