Potential lipolytic regulators derived from natural products as effective approaches to treat obesity

Abstract

Epidemic obesity is contributing to increases in the prevalence of obesity-related metabolic diseases and has, therefore, become an important public health problem. Adipose tissue is a vital energy storage organ that regulates whole-body energy metabolism. Triglyceride degradation in adipocytes is called lipolysis. It is closely tied to obesity and the metabolic disorders associated with it. Various natural products such as flavonoids, alkaloids, and terpenoids regulate lipolysis and can promote weight loss or improve obesity-related metabolic conditions. It is important to identify the specific secondary metabolites that are most effective at reducing weight and the health risks associated with obesity and lipolysis regulation. The aims of this review were to identify, categorize, and clarify the modes of action of a wide diversity of plant secondary metabolites that have demonstrated prophylactic and therapeutic efficacy against obesity by regulating lipolysis. The present review explores the regulatory mechanisms of lipolysis and summarizes the effects and modes of action of various natural products on this process. We propose that the discovery and development of natural product-based lipolysis regulators could diminish the risks associated with obesity and certain metabolic conditions.

Effectiveness of Bay Leaves (Syzygium polyanthum) to Reduce Body Mass Index Among Pre-Menopausal Obese Adults in South Jakarta Regency

“…Existing studies have also demonstrated that flavonoids can regulate lipolysis, promoting weight loss and improving metabolic conditions associated with obesity (X. Yang et al, 2022). Flavonoids have been linked to preventing weight regain after successful weight loss (Lundgren & Thaiss, 2020).…”

The role of TRPV ion channels in adipocyte differentiation: What is the evidence?

“…In addition, capsaicin chronically activates TRPV1‐induced Ca 2+ influx and induces the “browning” phenotype in 3T3‐L1‐adipocytes 82,107 . The activation of TRPV1 by dietary capsaicin increases CX43‐mediated Ca 2+ influx in adipocytes, thus promoting adipocyte differentiation 68,108 . It has been shown that TRPV2 knockout reduces Ca 2+ influx in BAT and weakens β‐adrenergic receptor‐stimulated thermogenesis 70,109 .…”

“…82,107 The activation of TRPV1 by dietary capsaicin increases CX43-mediated Ca 2+ influx in adipocytes, thus promoting adipocyte differentiation. 68,108 It has been shown that TRPV2 knockout reduces Ca 2+ influx in BAT and weakens β-adrenergic receptorstimulated thermogenesis. 70,109 Ye and colleagues reported that both genetic ablation and pharmacological inhibition of TRPV4 induce TRPV4-dependent Ca 2+ influx in adipocytes.…”

Natural H2S‐donors: A new pharmacological opportunity for the management of overweight and obesity

“…In an oversimplified scenario, the activation of lipolysis would represent a suitable treatment for overweight/obesity. However, experimental evidence shows the lack of lipolysis enzymes (such as adipose triglyceride lipase, hormone sensitive lipase, or lipase monoglyceride) in a nonobese or only moderately obese phenotype in humans and mice, while highlighting an increase in basal lipolysis in obesity (Yang, Ge, et al, 2022). The excessive release of free fatty acids may damage tissues, contribute to the progression of obesity, and promote obesity-associated metabolic complications, such as insulin resistance.…”