Coffee-Derived Phenolic Compounds Activate Nrf2 Antioxidant Pathway in I/R Injury In Vitro Model: A Nutritional Approach Preventing Age Related-Damages

Lonati, Elena; Carrozzini, Tatiana; Bruni, Ilaria; Mena, Pedro; Botto, Laura; Cazzaniga, Emanuela; Rio, Daniele Del; Labra, Massimo; Palestini, Paola; Bulbarelli, Alessandra

doi:10.3390/molecules27031049

Cited by 19 publications

(10 citation statements)

References 59 publications

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“…The ROS-scavenging activities of phenolics are structurally attributed to the presence of a benzene ring-bound hydroxyl that can react with ROS, including hydroxyl, superoxide, and peroxyl radicals [ 16 ]. Phenolics also exhibit anti-inflammatory activities by regulation of signaling pathways, including NF-κB and MAPKs [ 17 , 18 ]. NF-κB, a transcription factor, is a transducer of extracellular stress stimuli to intracellular responses, which is associated with the production of various pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and cytokines [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of Antioxidant and Anti-Inflammatory Properties of Papaya Extracts

Jeon

Chung²,

Kim³

et al. 2022

Foods

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Antioxidant and anti-inflammatory properties of papaya (Carica papaya) fruits were evaluated to provide comprehensive information associated with the bioactive compounds. ‘Tainung No. 2’ papaya fruits, cultivated in a greenhouse, Korea, were harvested at unripe and ripe stages and then divided into seed and peel-pulp. Total phenolic and flavonoid contents were determined using spectrophotometry, and individual phenolic compounds were relatively quantified by HPLC-DAD and fifteen standards. Antioxidant activities were measured using four assays: DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) scavenging activities, inhibition of lipid peroxidation, and FRAP (ferric reducing antioxidant power). Anti-inflammatory activities were measured by the regulation of NF-κB signaling pathways with the measurements of ROS and NO productions as the degree of oxidative stress. Total phenol contents increased in seed and peel–pulp extracts during ripening; flavonoid contents increased only in seed extracts. Total phenolic contents were associated with ABTS radical scavenging activity and FRAP. Of fifteen phenolic compounds, chlorogenic acid, cynarin, eupatorine, neochlorogenic acid, and vicenin II were identified among papaya extracts. ROS and NO productions were inhibited in papaya extracts. Especially, NO productions were inhibited higher in ripe seed extracts than in other extracts, which would be associated with the suppression of NF-κB activation and iNOS expression. These results suggest that papaya fruit extracts, including seeds, peels, and pulps, could be potential raw materials for functional foods.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of Antioxidant and Anti-Inflammatory Properties of Papaya Extracts

Jeon

Chung²,

Kim³

et al. 2022

Foods

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“…The evidence was further confirmed by Lemos and team [ 23 ], where CGA was found superior to perform antioxidant profiles and recorded an IR50 below 7.0 μg/mL. Recently, in an effort to reveal the antioxidant effects of CGA-derived circulating metabolites, an activation of the Nrf2/ARE pathway was demonstrated among coffee drinkers [ 24 ]. Consumption of coffee phytoextracts incremented nuclear localization and HO-1 expression.…”

Section: Coffee As Potent Antioxidantmentioning

confidence: 72%

Addressing the Neuroprotective Actions of Coffee in Parkinson’s Disease: An Emerging Nutrigenomic Analysis

Lee

Rodzi

2022

Antioxidants

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Caffeine is one of the predominant dietary components and psychostimulants present in coffee, a widely appreciated beverage. Corroborating epidemiological and laboratory evidence have suggested an inverse association between the dietary intakes of coffee and the risk of Parkinson’s Disease (PD). Growing attention has been paid to the impact of coffee consumption and genetic susceptibility to PD pathogenesis. Coffee is believed to play prominent roles in mediating the gene makeup and influencing the onset and progression of PD. The current review documents a current discovery of the coffee × gene interaction for the protective management of PD. The evidence underlying its potent impacts on the adenosine receptors (A2AR), estrogen receptors (ESR), heme oxygenase (HO), toxicant responsive genes, nitric oxide synthase (NOS), cytochrome oxidase (Cox), familial parkinsonism genetic susceptibility loci, bone marrow stromal cell antigen 1 (BST1), glutamate receptor gene and apolipoprotein E (APOE) genotype expressions is outlined. Furthermore, the neuroprotective mechanisms of coffee for the amelioration of PD are elucidated.

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“…Relieve cerebral ischemic damage by inhibiting ferroptosis and other methods [36]. An experiment on oxygen and glucose deprivation and recovery to simulate reperfusion showed that coffee byproducts reduce the accumulation of reactive oxygen species [37]. Eduardo M Ribeiro, et al found that coffee drinking was not associated with an increased risk of all-cause mortality and cardiovascular events in patients with previous myocardial infarction [38].…”

Section: Discussionmentioning

confidence: 99%

Association of coffee and caffeine consumption with risk of ischemic stroke: a Mendelian randomization study

Wang,

Gao,

Wang

et al. 2024

Preprint

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Background Previous research has not elucidated a causal relationship between coffee and caffeine intake and ischemic stroke. Methods Mendelian randomization (MR) studies were used to assess the causal relationship between coffee and caffeine consumption and the risk of ischemic stroke. Genetic statistically significant single nucleotide polymorphisms (SNPs) for coffee and caffeine intake served as instrumental variables (IVs). Ischemic stroke was used as the outcome, and the IVW, MR-Egger, simple mode, weighted mode, and weighted median methods were used for analysis, and the inverse variance weighting (IVW) method was used as the main method for MR analysis. Further sensitivity analysis was performed using MR-Egger and IVW to assess robustness. Results MR analysis results showed that coffee and caffeine intake were not associated with the risk of ischemic stroke. Twenty-three SNPs of coffee and 19 SNPs of caffeine were selected as IVs, and the F values of all SNPs were greater than 10. The study results show that genetic susceptibility to coffee intake is associated with IS (OR = 1.147, 95% CI: 0.704– 1.869, P = 0.583), and caffeine intake is associated with IS (OR = 0.93, 95% CI: 0.846– 1.021, P = 0.126) had no effect. After excluding SNPs with confounding factors, a sensitivity analysis was performed in this study, and the results were consistent. Conclusion The findings suggest there is insufficient evidence to support an association between coffee and caffeine intake and the risk of ischemic stroke. More research is needed to verify this in the future.

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Coffee-Derived Phenolic Compounds Activate Nrf2 Antioxidant Pathway in I/R Injury In Vitro Model: A Nutritional Approach Preventing Age Related-Damages

Cited by 19 publications

References 59 publications

Comprehensive Assessment of Antioxidant and Anti-Inflammatory Properties of Papaya Extracts

Comprehensive Assessment of Antioxidant and Anti-Inflammatory Properties of Papaya Extracts

Addressing the Neuroprotective Actions of Coffee in Parkinson’s Disease: An Emerging Nutrigenomic Analysis

Association of coffee and caffeine consumption with risk of ischemic stroke: a Mendelian randomization study

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