Coffee consumption prevents obesity-related comorbidities and attenuates brown adipose tissue whitening in high-fat diet-fed mice

Martins, Bruna Cadete; Soares, Alexandre Coelho; Martins, Fabiane Ferreira; Resende, Ângela de Castro; Inada, Kim Ohanna Pimenta; Souza-Mello, Vanessa; Moura‐Nunes, Nathália; Daleprane, Julio Beltrame

doi:10.1016/j.jnutbio.2023.109336

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…Another study involving lean and obese individuals demonstrated that caffeine led to increased energy expenditure and lipid oxidation [ 85 ]. Additionally, a focused study observed that caffeine treatment resulted in increased expression of UCP1 and thermogenic genes in BAT, indicating the potential for BAT activation [ 86 ]. Another study also showed that higher maternal caffeine intake during pregnancy was associated with a higher risk of overweight/obesity and shorter stature in childhood.…”

Section: Natural Productsmentioning

confidence: 99%

Brown Fat and Nutrition: Implications for Nutritional Interventions

Noriega,

Yang,

Wang

2023

Nutrients

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Brown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity. However, the translation of preclinical findings into effective clinical therapies poses challenges, warranting further research to identify the molecular mechanisms underlying the differentiation and function of brown and beige adipocytes. Consequently, research has focused on the development of drugs, such as mirabegron, ephedrine, and thyroid hormone, that mimic the effects of cold exposure to activate brown fat activity. Additionally, nutritional interventions have been explored as an alternative approach to minimize potential side effects. Brown fat and beige fat have emerged as promising targets for addressing nutritional imbalances, with the potential to develop strategies for mitigating the impact of metabolic diseases. Understanding the influence of nutritional factors on brown fat activity can facilitate the development of strategies to promote its activation and mitigate metabolic disorders.

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Section: Natural Productsmentioning

confidence: 99%

Brown Fat and Nutrition: Implications for Nutritional Interventions

Noriega,

Yang,

Wang

2023

Nutrients

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Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update

Martins,

Teixeira

et al. 2024

Molecular Nutrition Food Res

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The discovery of metabolically active brown adipose tissue (BAT) in human adults and the worldwide increase in obesity and obesity‐related chronic noncommunicable diseases (NCDs) has made BAT a therapeutic target in the last two decades. The potential of BAT to oxidize fatty acids rapidly and increase energy expenditure inversely correlates with adiposity, insulin and glucose resistance, and cardiovascular and metabolic diseases. Currently, BAT is recognized by a new molecular signature; several BAT‐derived molecules that act positively on target tissues have been identified and collectively called batokines. Bioactive compounds present in foods are endowed with thermogenic properties that increase BAT activation signaling. Understanding the mechanisms that lead to BAT activation and the batokines secreted by it within the thermogenic state is fundamental for its recruitment and management of obesity and NCDs. This review contributes to recent updates on the morphophysiology of BAT, its endocrine role in obesity, and the main bioactive compounds present in foods involved in classical and nonclassical thermogenic pathways activation.

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Preventive effects of caffeine on nicotine plus high-fat diet-induced hepatic steatosis and gain weight: a possible explanation for why obese smokers with high coffee consumption tend to be leaner

Lu,

Mei,

et al. 2023

Br J Nutr

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Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder, affecting approximately 25% of the population. Coffee-drinking obese smokers exhibit lower body weights and decreased NAFLD rates, but the reasons behind this remain unclear. Additionally, the effect of nicotine, the main component of tobacco, on the development of NAFLD is still controversial. Our study aimed to explore the possible reasons that drinking coffee could alleviate NAFLD and gain weight, and identify the real role of nicotine in NAFLD of obese smokers. A NAFLD model in mice was induced by administering nicotine and a high-fat diet (HFD). We recorded changes in body weight and daily food intake, measured the weights of the liver and visceral fat, and observed liver and adipose tissue histopathology. Lipid levels, liver function, liver malondialdehyde (MDA), superoxide dismutase (SOD), serum inflammatory cytokine levels, and the expression of hepatic genes involved in lipid metabolism were determined. Our results demonstrated that nicotine exacerbated the development of NAFLD, and caffeine had a hepatoprotective effect on NAFLD. The administration of caffeine could ameliorate nicotine-plus-HFD-induced NAFLD by reducing lipid accumulation, regulating hepatic lipid metabolism, alleviating oxidative stress, attenuating inflammatory response, and restoring hepatic functions. These results might explain why obese smokers with high coffee consumption exhibit the lower incidence rate of NAFLD and tend to be leaner. It is essential to emphasize that the detrimental impact of smoking on health is multifaceted. Smoking cessation remains the sole practical and effective strategy for averting the tobacco-related complications and reducing the risk of mortality.

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Coffee consumption prevents obesity-related comorbidities and attenuates brown adipose tissue whitening in high-fat diet-fed mice

Cited by 4 publications

References 54 publications

Brown Fat and Nutrition: Implications for Nutritional Interventions

Brown Fat and Nutrition: Implications for Nutritional Interventions

Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update

Preventive effects of caffeine on nicotine plus high-fat diet-induced hepatic steatosis and gain weight: a possible explanation for why obese smokers with high coffee consumption tend to be leaner

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