Coffee consumption, health benefits and side effects: a narrative review and update for dietitians and nutritionists

Barrea, Luigi; Pugliese, Gabriella; Frías-Toral, Evelyn; Ghoch, Marwan El; Castellucci, Bianca; Chapela, Sebastián Pablo; Carignano, Maria de los Angeles; Laudisio, Daniela; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna

doi:10.1080/10408398.2021.1963207

Cited by 42 publications

(36 citation statements)

References 201 publications

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“…Caffeine and SCS, as the bioactive components of food, have the ability to prevent inflammatory and oxidative stress-related diseases, such as obesity, metabolic syndrome and type 2 diabetes. 27,28 The most important mechanism of the anti-obesity of caffeine appears to be the antagonism of adenosine receptors, the density of which in adipose tissue was higher than in other tissues. Mature adipocytes contain A1 adenosine receptors that inhibit lipolysis by decreasing adenylate cyclase activity, 29 suggesting that caffeine might have an important effect on lipid accumulation via promoting lipolysis.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, SCS could slow down the metabolism of caffeine, thereby maintaining caffeine in the body for a long action time. Based on the previous studies that caffeine and SCS alone could alleviate the abnormal glucose and lipid metabolism, [27][28][29][30][31][32] the combination of the two substances not only exerted the effect of SCS, but also prolonged the effect of caffeine, thereby promoting the improvement of glucose and lipid metabolism. Collectively, SCS in conjunction with caffeine showed a better effect in improving insulin resistance and lipid metabolism, especially inhibiting lipid accumulation and controlling weight gain.…”

Section: Discussionmentioning

confidence: 99%

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The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high‐fat diet‐fed mice by extending the action duration of caffeine

Zhao

et al. 2022

J Sci Food Agric

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BACKGROUND Sea cucumber saponins (SCSs) exhibit a unique structure and high bioactivities and might have specialized implications on caffeine metabolic process by altering the activity of N‐demethylation enzyme CYP1A2. The present study aimed to clarify the effects of SCS on caffeine metabolism in vivo and in vitro, as well as the synergistic anti‐obesity effect of SCS and caffeine on high‐fat diet‐induced obese mice. RESULTS Results found that SCS administration significantly postponed the elimination rate of caffeine and its metabolites in vivo, and further study found CYP1A2‐mediated caffeine metabolism was remarkably inhibited in a dose‐dependent manner in vitro. The synergistic effect of the SCS and caffeine combination could decrease the total weight of white adipose tissue by 52% compared with high‐fat diet‐treated group. CONCLUSION SCS could prolong caffeine action time, and the combination of the two substances exhibited joint action on high‐fat diet‐induced obese mice. These findings might provide a basis for the development of functional foods and potential application using the combination of SCS and caffeine. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high‐fat diet‐fed mice by extending the action duration of caffeine

Zhao

et al. 2022

J Sci Food Agric

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“…Medical herbs are known to be ideal for human health because they have fewer side effects than synthetic medications [ 8 ]. In addition to stimulating the nervous system, coffee oil has been shown to improve mood, alertness, and other psychoactive responses, neurological disorders, and metabolic syndrome conditions [ 9 , 10 ]. When it comes to the prevention of various diseases, olive oils are an essential ingredient in Mediterranean diets.…”

Section: Introductionmentioning

confidence: 99%

Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion

Zeid

Al-Asmari

Altayb

et al. 2022

Life

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Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks. Exposure to MAL resulted in statistically altered antioxidant enzymes and histopathological findings of necrotic seminiferous tubules and spermatogenetic arrest in rats after seven weeks of treatment. The effects of MAL intoxication on physiological and histopathological changes were improved by the use of these oils. Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Coffee oil and olive oil were found to be promising therapeutic agents for MAL-induced testicular toxicity and oxidative damage.

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“…Coffee is most widely used hot beverage all over the world. It helps in preventing inflammation and diseases related to oxidative stress (Barrea et al 2021). Based on the type of processing, the composition of waste generated and quality of coffee beans will vary.…”

Section: Introductionmentioning

confidence: 99%

Optimization by uniform design U8(83) approach for enhanced caffeine degradation in synthetic wastewater in bioreactor

Shanmugam

Gummadi

2022

Letters in Applied Microbiology

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Significance and Impact of the Study: Caffeine degradation in coffee wastewater is crucial but less explored area in current treatment strategies. This research focus on the caffeine degradation in a reactor where we used uniform design methodology and mathematical model derived from its data. Experimental design yielded a highest caffeine degradation of 23Á59 mg L −1 h −1 at 0Á3 g L −1 biomass, 200 rev min −1 and 1Á8 vvm which is highest ever reported along with reduction of critical parameters like COD, BOD and TOC. Regression model developed from experimental data predicted an optimum caffeine degradation rate of 24Á2 mg L −1 h −1 at 0Á35 g L −1 , 395 rev min −1 and 1Á62 vvm which was confirmed experimentally.

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Coffee consumption, health benefits and side effects: a narrative review and update for dietitians and nutritionists

Cited by 42 publications

References 201 publications

The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high‐fat diet‐fed mice by extending the action duration of caffeine

The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high‐fat diet‐fed mice by extending the action duration of caffeine

Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion

Optimization by uniform design U8(83) approach for enhanced caffeine degradation in synthetic wastewater in bioreactor

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