The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high‐fat diet‐fed mice by extending the action duration of caffeine
Abstract:BACKGROUND
Sea cucumber saponins (SCSs) exhibit a unique structure and high bioactivities and might have specialized implications on caffeine metabolic process by altering the activity of N‐demethylation enzyme CYP1A2. The present study aimed to clarify the effects of SCS on caffeine metabolism in vivo and in vitro, as well as the synergistic anti‐obesity effect of SCS and caffeine on high‐fat diet‐induced obese mice.
RESULTS
Results found that SCS administration significantly postponed the elimination rate of… Show more
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