Coffee Consumption and Risk of Stroke in Women

Larsson, Susanna C.; Virtamo, Jarmo; Wolk, Alicja

doi:10.1161/strokeaha.110.603787

Cited by 85 publications

(68 citation statements)

References 19 publications

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“…But the threshold daily amount of theobromine to modulate platelet function requires further investigation. Studies of coffee consumption, where caffeine is clearly a key bioactive, have also shown a reduced risk of CHD mortality and ischaemic stroke in habitual coffee drinkers [45][46][47]. When these findings are considered in conjunction with observations from chocolate studies, this suggests that daily intake of methylxanthines is a key dietary factor modulating platelet function.…”

Section: Platelet Aggregationmentioning

confidence: 88%

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

Rull

Zain

Shiel

et al. 2015

Vascular Pharmacology

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Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg flavanols/day for 6 weeks) on blood pressure, heart rate, vascular function and platelet aggregation in men with pre-hypertension or mild hypertension. Vascular function was assessed by pulse wave analysis using radial artery applanation tonometry in combination with inhaled salbutamol (0.4 mg) to assess changes due to endothelium-dependent vasodilatation. HFDC did not significantly reduce blood pressure compared to baseline or LFDC. Heart rate was increased by LFDC compared to baseline, but not by HFDC. Vascular responses to salbutamol tended to be greater after HFDC. Platelet aggregation induced by collagen or the thromboxane analogue U46619 was unchanged after LFDC or HFDC, whereas both chocolates reduced responses to ADP and the thrombin receptor activator peptide, SFLLRNamide (TRAP6), relative to baseline. Pre-incubation of platelets with theobromine also attenuated platelet aggregation induced by ADP or TRAP6. We conclude that consumption of HFDC confers modest improvements in cardiovascular function. Platelet aggregation is modulated by a flavanol-independent mechanism that is likely due to theobromine.

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Section: Platelet Aggregationmentioning

confidence: 88%

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

Rull

Zain

Shiel

et al. 2015

Vascular Pharmacology

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“…[10,107] Coffee consumption is the principal supply of antioxidants in the western diet; reduce the risk of cardiovascular and other inflammatory diseases in postmenopausal women.…”

Section: Health Benefit Of Coffee Consumption Description Of Action Smentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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Coffee is the world's beloved drink that is the most regularly consumed caffeine-containing beverage next to water and tea. It contains a multipart combination of chemicals constituents, which associated with health benefits, most consumers, begin their day with a minimum a cup of coffee after eating food, and end their workday with coffee. It is considered as a significant part of modern daily life because it has an alerting outcome on the human brain. Opposing this, various groups report experiencing uneven health risks thus hesitant to drink coffee, this suggests individual disparity to coffee intolerance. The aim of this review was to in brief summarize health benefits and risks coffee consumption. Most of the informative reports suggested that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among these it is used to boosts our physical performance, burn fat, reduces risk of stroke, liver, prostate and colorectal cancer by 20%, risk of Parkinson's disease by 25%, lower risk of Type II diabetes, reduces risk of dementia and protects our mind, brightens our mood, helps us to fight depression and minimize risk of suicide by 50%. In addition, coffee consumers have less risk of heart disease, with strongly integrated DNA. Also reports that coffee drinking has also naturally extended sleep latency, minimizes total sleep time and its effectiveness, and worsened supposed sleep feature.However, from positive health prospect of coffee consumption, a recent study finds coffee consumption does not always provide protective benefits because overdrinking is associated with negative impact or risk on our health. Some negative impact of coffee consumption on our health; it reduces appetite levels for food, impact on pregnant women, on people with cholesterol, cause insomnia and restlessness, breast tissue cysts in women, incontinence digestive disorders, and risk of headaches. In addition, decrease fertility probability in female and male, cause allergies and miscarriage, forceful heart contractions, anxiety, depression and the need for anxiety medication, inhibits collagen production in the skin of human being, less hearing loss improvement, does not help with extended sleep deprivation interferes with ossification and could also lead to greater risk of bone fracture. Finally, the most recent studies reported that coffee consumption is beneficial for our health when it is optimum range approximately four cups on average. The supplementary research will be crucial to make clear that both the health benefits and risk of coffee consumption.

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“…Recently, in a cohort of Swedish women (coffee >1 cups/day), risk of stroke was reduced in CI, but not in ICH, compared with <1 cup/day. 8 In recent meta-analyses, the association between coffee consumption and the risk of CHD still remains controversial. 29,30 Our study showed no significant association between coffee consumption and CHD.…”

Section: May 2013mentioning

confidence: 99%

The Impact of Green Tea and Coffee Consumption on the Reduced Risk of Stroke Incidence in Japanese Population

Kokubo

Iso

Saito

et al. 2013

Stroke

138

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Background and Purpose— Few prospective studies have examined the impact of both green tea and coffee consumption on strokes. We investigated the association of the combination of those consumption with stroke incidence in a general population. Methods— We studied 82 369 Japanese (aged 45–74 years; without cardiovascular disease [CVD] or cancer in 1995 and 1998 for Cohort I and II, respectively) who received 13 years of mean follow-up through the end of 2007. Green tea and coffee consumption was assessed by self-administered food frequency questionnaire at baseline. Results— In the 1 066 718 person-years of follow-up, we documented the incidence of strokes (n=3425) and coronary heart disease (n=910). Compared with seldom drinking green tea, the multivariable-adjusted hazard ratios (95% confidence intervals) of all strokes were 0.86 (0.78–0.95) and 0.80 (0.73–0.89) in green tea 2 to 3 and ≥4 cups/d, respectively. Higher green tea consumption was associated with inverse risks of CVD and strokes subtypes. Compared with seldom drinking coffee, the multivariable-adjusted hazard ratios (95% confidence intervals) of all strokes were 0.89 (0.80–0.99), 0.80 (0.72–0.90), and 0.81 (0.72–0.91) for coffee 3 to 6 times/week and 1 and ≥2 times/day, respectively. Coffee consumption was associated with an inverse risk of CVD and cerebral infarction. Higher green tea or coffee consumption reduced the risks of CVD and stroke subtypes (especially in intracerebral hemorrhage, P for interaction between green tea and coffee=0.04). None of the significant association was observed in coronary heart disease. Conclusions— Higher green tea and coffee consumption were inversely associated with risk of CVD and stroke in general population.

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Coffee Consumption and Risk of Stroke in Women

Cited by 85 publications

References 19 publications

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

Review on Health Benefit and Risk of Coffee Consumption

The Impact of Green Tea and Coffee Consumption on the Reduced Risk of Stroke Incidence in Japanese Population

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