Coffee Consumption and Pancreatic Cancer Risk: A Meta-Epidemiological Study of Population-based Cohort Studies

Abstract

Objective: Previous systematic reviews evaluating the association between coffee consumption and pancreatic cancer showed inconsistent results. The aim was to conduct a meta-epidemiological study to explore further the association between coffee consumption and the incidence of pancreatic cancer. Methods: The selection criteria were defined as a population-based prospective cohort study reporting adjusted relative risk (RR) and their 95% confidence interval (95%CI) of pancreatic cancer occurrence according to coffee consumption. Adjusted RR for the highest versus the lowest level of coffee consumption in each study was extracted. A fixed-effect model was applied to calculate a summary RR (sRR) and its 95%CI. Two-stage random-effects dose-response meta-analysis (DRMA) was performed to estimate the incidence risk per unit dose (cup per day). Results: Twelve cohort studies were selected for meta-analysis. The total number of cohort participants was 3,230,053, and pancreatic cancer incidents were 10,587. The sRR of pancreatic cancer risk for the highest versus the lowest level of coffee consumption indicated no statistical significance (sRR=0.98, 95% CI: 0.88-1.10; I-squared=0.0%). Two-stage random-effect DRMA showed the non-linear relationship between the amount of coffee consumption and pancreatic cancer risk. And the RR for an increment of one cup per day of coffee consumption was 0.97 (95%CI: 0.91-1.04, P=0.42), without statistically significant. Conclusion: There was no association between coffee consumption habits and pancreatic cancer risk. And there was no statistical significance in the dose-response relationship between the amount of coffee consumption and pancreatic cancer risk. Finding the turning point would be important because it can be critical information for the prevention of pancreatic cancer.

Type 2 diabetes prevention diet and the risk of pancreatic cancer: A large prospective multicenter study

“…In this study, we observed an inverse association between coffee consumption and the risk of pancreatic cancer, indicating that coffee could be a main contributor to the observed association of type 2 prevention diabetes diet with the risk of pancreatic cancer. Notably, the association of coffee consumption with the risk of pancreatic cancer has been debated for decades; however, most previous studies revealed a null association [37]. A recent prospective study of 193,439 subjects found that increased consumption of filtered coffee was associated with a reduced risk of pancreatic cancer (HR for 4 versus 1 cup/day: 0.74; 95% CI: 0.57, 0.95), while such an inverse association was not found for total and boiled coffee consumption [38].…”

Pro-Inflammatory Food, Gut Microbiota, and Cardiovascular and Pancreatic Diseases

“…A meta-analysis by Gao et al examined 25 studies and showed that there was no appreciable link between fish intake and pancreatic cancer risk with an RR of 1.00 (95% CI: 0.93-1.07) [41]. A meta-analysis by Bae et al with twelve cohort studies and 10,587 pancreatic cancer incidents showed no increased risk of pancreatic cancer among patients with the highest versus the lowest level of coffee consumption with a summary RR of 0.98 (95% CI: 0.88-1.10) [38].…”

Analysis of levels and Clinical value of CA19-9, NLR and SIRI in patients with Pancreatic Cancer with different Clinical Features

“…Pancreatic cancer is a common malignant tumor in the clinic (1). Foreign investigation results show that pancreatic cancer ranks fourth in tumor mortality and is the digestive system tumor with the worst prognosis (2).…”