Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies

Bravi, Francesca; Tavani, Alessandra; Bosetti, Cristina; Boffetta, Paolo; Vecchia, Carlo La

doi:10.1097/cej.0000000000000252

Cited by 112 publications

(82 citation statements)

References 47 publications

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“…To elucidate this issue, five systematic reviews or meta-analyses have been published7891035. In a meta-analysis of four cohort and 5 case-control studies, Larsson et al .…”

Section: Discussionmentioning

confidence: 99%

“…performed an updated meta-analysis of cohort studies and observed a 15% decreased risk in liver cancer for an increment of 1 cup of coffee per day35. In a model comparing regular, low, and high consumption with no or occasional coffee consumption, the pooled RRs with 95 CIs were 0.66 (0.55–0.78) for regular, 0.78 (0.66–0.91) for low, and 0.50 (0.43–0.58) for high coffee consumption, respectively 35. Compared with previous meta-analyses, our study had two major strengths.…”

Section: Discussionmentioning

confidence: 99%

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An updated dose–response meta-analysis of coffee consumption and liver cancer risk

Cao

Chen

et al. 2016

Sci Rep

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Prospective cohort studies of the relationship between coffee consumption and liver cancer risk have drawn different conclusions. Therefore, a dose-response meta-analysis of prospective cohort studies was performed to disentangle this causal relationship. Prospective cohort studies of the association between coffee consumption and liver cancer risk published prior to Jan 9, 2016 were identified by searching in the PubMed and EMBASE databases. Extracted data were analyzed using a random-effects model. Of the 2892 records identified using the search strategy, a total of twenty cohort studies from ten publications were included in the final meta-analysis. The pooled estimate of relative risk (RR) with 95% confidence interval (CI) for highest vs. non/occasional coffee drinkers was 0.55(0.44–0.67). No evidence of publication bias was observed (p for Egger’s test = 0.229). Sensitivity analysis indicated the results were robust. Dose-response analysis revealed a significant linear dose-response relationship between coffee consumption and liver cancer risk (p = 0.36). Subgroup analyses stratified by pre-specified variables (gender, geographic region, and adjusted factors) indicated similar results within individual subgroups. Our meta-analysis suggested that coffee consumption is inversely associated with liver cancer risk.

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“…To elucidate this issue, five systematic reviews or meta-analyses have been published7891035. In a meta-analysis of four cohort and 5 case-control studies, Larsson et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An updated dose–response meta-analysis of coffee consumption and liver cancer risk

Cao

Chen

et al. 2016

Sci Rep

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“…Increased consumption of tea and coffee, two of the most popular beverages worldwide, has been associated with decreased risk of cancers of several sites in human studies. [1][2][3][4][5][6][7][8][9][10] Less is known about the association between tea or coffee consumption and risk of glioma, a cancer for which few lifestyle factors have been identified. 11,12 Coffee is a rich source of caffeine, and both tea and coffee contain additional biologically active compounds.…”

Section: Introductionmentioning

confidence: 99%

A prospective study of tea and coffee intake and risk of glioma

Coté

Bever

Wilson

et al. 2019

Intl Journal of Cancer

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Tea and coffee have antioxidant and neuroprotective effects. Observational studies suggest that tea and coffee intake may reduce cancer risk, but data on glioma risk are inconclusive. We evaluated the association between tea, coffee and caffeine intake and glioma risk in the female Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) and the male Health Professionals Follow‐Up Study (HPFS). Cumulative intake was derived from validated quadrennial food frequency questionnaires. Glioma cases were confirmed by medical record review. Multivariable‐adjusted hazard ratios of glioma by beverage intake category were estimated using Cox proportional hazards models. We documented 554 incident cases of glioma (256 in NHS, 87 in NHSII and 211 in HPFS). Compared to <1 cup/week, higher tea consumption was borderline inversely associated with glioma risk in pooled cohorts (hazard ratio [HR] = 0.73, 95% confidence interval [CI]: 0.49–1.10 for >2 cups/day, p‐trend = 0.05), but not in women (HR = 0.74, 95% CI: 0.47–1.18 for >2 cups/day, p‐trend = 0.11) or men (HR = 0.70, 95% CI: 0.30–1.60 for >2 cups/day, p‐trend = 0.30) separately. Overall, we observed no significant associations between caffeinated, decaffeinated or total coffee intake and glioma risk. There were no material differences in the results with baseline values, 8‐year lagged responses, or when limited to glioblastoma (n = 362). In three large prospective cohort studies, tea intake was borderline inversely associated with glioma risk. No significant associations were observed for coffee intake and glioma risk. These results merit further exploration in prospective studies.

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“…Previous epidemiologic studies have evaluated the association between increased coffee consumption and reduced cancer risk. Also, several recent meta-analyses show a positive effect of coffee consumption on preventing liver cancer [10], endometrial cancer [11], and oral cancer [7]. …”

Section: Introductionmentioning

confidence: 99%

Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis

Han

Kim

2017

IJERPH

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An inverse association has been reported between coffee consumption and the risk of several cancers. However, the association between coffee and thyroid cancer is controversial. Thus, this study aimed to evaluate the association between coffee consumption and the risk of thyroid cancer through a systematic review and meta-analysis. Published studies were examined from PubMed, Embase, Cochrane Central, and the reference lists of the retrieved articles. The summary odds ratio (OR) for the association between coffee consumption was categorized as highest versus lowest consumption, and thyroid cancer risk was calculated using a fixed effects model. Subgroup analyses by study design, geographic location, source of controls, and adjusted variables were performed. A total of 1039 thyroid cancer cases and 220,816 controls were identified from five case-control studies and two cohort studies. The summary OR for the association between coffee consumption and thyroid cancer risk was 0.88 (95% confidence interval (CI) = 0.71–1.07). There was no significant heterogeneity among the study results (I² = 0%, p = 0.79). However, the beneficial effect of coffee consumption on thyroid cancer was found only in hospital-based case-control studies (OR= 0.59, 95% CI= 0.37–0.93). There was no significant association between coffee consumption and thyroid cancer risk according to our meta-analysis results. These findings should be interpreted with caution because of potential biases and confounding variables. Further prospective studies with a larger number of cases are encouraged to confirm these results.

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Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies

Cited by 112 publications

References 47 publications

An updated dose–response meta-analysis of coffee consumption and liver cancer risk

An updated dose–response meta-analysis of coffee consumption and liver cancer risk

A prospective study of tea and coffee intake and risk of glioma

Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis

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