Coffee and the Liver

Arauz, Jonathan; Ramos‐Tovar, Erika; Muriel, Pablo

doi:10.1016/b978-0-12-804274-8.00048-5

Cited by 7 publications

(6 citation statements)

References 87 publications

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“…Also, some other mechanisms responsible for the beneficial effects of coffee intake on the liver have been hypothesized including immunomodulatory, antiinflammatory, and antifibrotic mechanisms. 24 Furthermore, the present study showed a significant reduction in the mean serum levels of TB and unconjugated bilirubin in the participants studied after the consumption of coffee when compared with baseline values respectively. However, there was no significant difference in the mean serum ALP activity (p=0.954), as well as conjugated bilirubin level in participants after the consumption of coffee when compared baseline (p>0.05).…”

Section: Discussionsupporting

confidence: 53%

Effect of coffee consumption on liver enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase), total and conjugated bilirubin levels among students in Nnewi

et al. 2020

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Background: Coffee has a number of bioactive compounds that have beneficial effects on human health in general and more importantly is the fact that coffee consumption has positive impact on the liver function. The present study investigated the effect of coffee consumption on liver enzymes: alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), total bilirubin (TB) and conjugated bilirubin (CB) levels among student in Nnewi.Methods: A total of twenty-five (25) apparently healthy participants aged between 18 and 30 years which were randomly recruited from College of Health Sciences’ students to serve as both test and control group. Each participant was advised to abstain from coffee and similar beverages for a period of three weeks prior to the commencement of the study. Subsequently, in addition to their normal diet, each of the subjects was given 2 gm of coffee dissolved in 150 ml of hot water in which 50 mg of non-dairy creamer was added before breakfast daily for 28 consecutive days. 6 ml each of baseline and test samples (after an overnight fast) were collected at day 0 and 29 respectively from each participant. Liver enzymes such as ALT, AST, and ALP activity as well as TB and CB levels was determined using standard laboratory methods.Results: This showed significant reductions in the mean serum AST and ALT activity, TB and unconjugated bilirubin (UB) levels with no significant alterations in the mean ALP activity and CB level in participants studied after short-term coffee consumption.Conclusions: This study revealed the hepatoprotective effect of coffee intake at short term basis.

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Section: Discussionsupporting

confidence: 53%

Effect of coffee consumption on liver enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase), total and conjugated bilirubin levels among students in Nnewi

et al. 2020

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“…On the other hand, increasing evidence indicates that caffeine can protect the liver from various types of acute and chronic damage (Arauz et al 2017;Ramos-Tovar and Muriel 2019;Vargas-Pozada and Muriel 2020). Previous studies have suggested that caffeine may have therapeutic potential against NASH; however, no studies have demonstrated the efficacy of caffeine in this disease, and its mechanism of action is largely unknown.…”

Section: Discussionmentioning

confidence: 99%

The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats

Vargas-Pozada

Ramos‐Tovar²,

Acero-Hernández

et al. 2023

Can. J. Physiol. Pharmacol.

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The antioxidant effect of caffeine, associated with its ability to upregulate the nuclear factor-E2-related factor-2 (Nrf2)-signaling pathway, was explored as a possible mechanism for the attenuation of liver damage. Nonalcoholic steatohepatitis (NASH) was induced in rats by the administration of a high-fat, high-sucrose, high-cholesterol diet (HFSCD) for 15 weeks. Liver damage was induced in rats by intraperitoneal administration of thioacetamide (TAA) for six weeks. Caffeine was administered orally at a daily dose of 50 mg/kg body weight during the period of NASH induction to evaluate its ability to prevent disease development. Meanwhile, rats received TAA for three weeks, after which 50 mg/kg caffeine was administered daily for three weeks with TAA to evaluate its capacity to interfere with the progression of hepatic injury. HFSCD administration induced hepatic steatosis, decreased Nrf2 levels, increased oxidative stress, induced the activation of nuclear factor-κB (NF-κB), and elevated proinflammatory cytokine levels, leading to hepatic damage. TAA administration produced similar effects, excluding steatosis. Caffeine increased Nrf2 levels; attenuated oxidative stress markers, including malondialdehyde and 4-hydroxynonenal; restored normal, reduced glutathione levels; and reduced NF-κB activation, inflammatory cytokine levels, and damage. Our findings suggest that caffeine may be useful in the treatment of human liver diseases.

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“…Other underlying etiologies implicated in liver diseases include viral hepatitis B & C, non-alcoholic steatohepatitis, certain autoimmune diseases, and as mentioned earlier drugs and certain pharmaceuticals, typically used to fight these diseases, can cause liver or kidney damage. Pharmacological agents through their metabolism produce oxidative stress and inflammation resulting overtime in organ fibrosis [17,18]. Organ fibrosis begins as an imbalance between the synthesis and degradation of the extracellular matrix (ECM), inducing remodeling and loss of key components which further exacerbates to fibrosis, as the structural integrity of the ECM becomes compromised [19].…”

Section: Non-communicable Diseasesmentioning

confidence: 99%

“…Interestingly this leads also to high expression of CTGF and in turn inducing a vicious cycle of profibrotic cytokines [23]. Compounds found in coffee are known to have a reducing effect over fibrosis by restoring redox balance, thereby inactivating the mechanisms that induce HSC differentiation, particularly caffeine blocks smooth muscle alpha and MMP2 and 9 [18,24]. In addition, the overall protective effects of coffee are seen even in the mitochondria as HSP70, an innate immune defense factor is activated, also DJ-1 autophagy factor and redox-sensing protein (ROS scavenger) activates inducing glutathione synthesis [4,25].…”

Section: Coffeementioning

confidence: 99%

A molecular outlook review on how coffee and oats can help redefine the way we take care of our health

Delgado-Gallegos¹,

Garza-Juarez²,

G-Buentello³

et al. 2021

TheGMS

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Chronic degenerative diseases like obesity, metabolic syndrome, diabetes, fatty liver, have gained high prevalence in the world, due to sedentarism, improper nutritional habits as well as alcohol and tobacco consumption. Studies have shown that regular consumption of breakfast leads to a wide range of benefits, especially for the liver. The liver is a key organ for metabolic homeostasis regulating and governing energy metabolism, mostly providing nutrients for reabsorption. Benefits of a nutrimental quality breakfast seem to help lower body mass index, prevent metabolic diseases, and overall improve quality of life. Unfortunately, these include either high cholesterol or high-sugar foods including cold cuts, bread, eggs, and sugary beverages. Also, much of the population’s work schedule relates to long hours and high-level of stress, therefore malnutrition, and inadequate eating schedules are common.

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Coffee and the Liver

Cited by 7 publications

References 87 publications

Effect of coffee consumption on liver enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase), total and conjugated bilirubin levels among students in Nnewi

Effect of coffee consumption on liver enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase), total and conjugated bilirubin levels among students in Nnewi

The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats

A molecular outlook review on how coffee and oats can help redefine the way we take care of our health

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