Coexpression of interleukin-8 receptors in head and neck squamous cell carcinoma

Richards, Bryan L.; Eisma, Roselle J.; Spiro, Jeffrey D.; Lindquist, R R; Kreutzer, Donald L.

doi:10.1016/s0002-9610(97)00165-7

Cited by 92 publications

(56 citation statements)

References 20 publications

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“…The metastatic and angiogenic abilities of a number of tumors have been attributed to elevated levels of ELR þ , angiogenic chemokines such as CXCL1 (Strieter et al, 1995;Keane et al, 1997). The role of these chemokines in tumor growth has also been implicated in many tumor types, including pancreas, head and neck, and non-small-cell lung tumors (Olbina et al, 1996;Richards et al, 1997;Takamori et al, 2000). Thus, it is imperative to discern the mechanisms by which these chemokines are regulated in order to develop targeted therapy in cancer and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…The NF-kB transcription factor represents a central and important component in the transcription of many chemokines. Interestingly, elevated expression of angiogenic chemokines has been observed in many tumor cell types, implicating a role for chemokines in neoplasia (Olbina et al, 1996;Richards et al, 1997;Takamori et al, 2000;Li et al, 2001;Haqq et al, 2005). Constitutive expression of the angiogenic chemokine, CXC ligand 1 (CXCL1), has been shown to transform immortalized melanocytes (Balentien et al, 1991), and high levels of endogenous CXCL1 and CXCL8 have been detected in melanoma (Schadendorf et al, 1994(Schadendorf et al, , 1996Owen et al, 1997;Haghnegahdar et al, 2000;Li et al, 2001;Yang and Richmond, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1

Amiri

Smulson

et al. 2006

Oncogene

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The continuous production of the CXC ligand 1 (CXCL1) chemokine by melanoma cells is a major effector of tumor growth. We have previously shown that the constitutive expression of this chemokine is dependent upon transcription factors nuclear factor-kappa B (NF-jB), stimulating protein-1 (SP1), high-mobility group-I/Y (HMGI/Y), CAAT displacement protein (CDP) and poly(ADPribose) polymerase-1 (PARP-1). In this study, we demonstrate for the first time the mechanism of transcriptional regulation of CXCL1 through PARP-1 in melanoma cells. In its inactive state, PARP-1 binds to the CXCL1 promoter in a sequence-specific manner and prevents binding of NF-jB (p65/p50) to its element. However, activation of the PARP-1 enzymatic activity enhances CXCL1 expression, owing to the loss of PARP-1 binding to the CXCL1 promoter, accompanied by enhanced binding of p65 to the promoter. The delineation of the role of NF-jB-interacting factors in the putative CXCL1 enhanceosome will provide key information in developing strategies to block constitutive expression of this and other chemokines in cancer and to develop targeted therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1

Amiri

Smulson

et al. 2006

Oncogene

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“…It can induce migration in some tumour cells (Wang et al, 1990) and has been implicated in the induction of angiogenesis in such diverse diseases as psoriasis (Schroeder and Christopher, 1986), rheumatoid arthritis (de Marco et al, 1991), idiopathic pulmonary fibrosis (Keane et al, 1997) and some malignant diseases (Folkman, 1986(Folkman, , 1990. Previous studies have demonstrated that IL-8 is expressed by lung (Strieter et al, 1995), bladder (Tachibana et al, 1997), prostate (Green et al, 1997) and head and neck squamous carcinomas (Richards et al, 1997), astrocytoma (Van Meir et al, 1992 and malignant melanoma (Schandendorf et al, 1993;Singh et al, 1994). It has been reported that IL-8 acts as an angiogenic factor in lung carcinoma Strieter et al, 1995;Arenberg et al, 1996); however, the function of IL-8 in the other carcinomas has not been clarified.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, IL-8 up-regulates collagenase type IV mRNA expression and collagenase activity by melanoma cells (Luca et al, 1997) and stimulate cell motility (Wang et al, 1990). Recent studies have shown that IL-8 receptors, IL-8RA and IL-8RB, are expressed by not only microvessel endothelial cells but also tumour cells in head and neck squamous cell carcinoma (Richards et al, 1997) and breast carcinoma (Miller et al, 1998). Therefore, IL-8 may play an important role in tumour growth and progression by both autocrine and paracrine mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice

et al. 1999

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SummaryThe growth and spread of tumour cells depends on adequate vasculature. We have previously reported that the expression of interleukin-8 (IL-8) directly correlates with the vascularity of human gastric carcinomas. To provide evidence for a causal role of IL-8 in angiogenesis and tumorigenicity of human gastric cancer, we used the lipofectin method to stably transfect the human TMK-1 gastric carcinoma cells (low endogenous IL-8) with an IL-8 expression vector or control vector. Transfection with IL-8 did not affect the proliferation of cultured cells, yet the culture supernatants of the transfected (but not control) cells stimulated proliferation of human umbilical vein endothelial cells. The IL-8-transfected and control cells were injected into the gastric wall of nude mice. IL-8-transfected cells produced rapidly growing, highly vascular neoplasms as compared to control cells. These results provide direct evidence for the role of IL-8 in the angiogenesis and tumorigenicity of human gastric carcinomas.

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“…CXCR2 has been described to be expressed on a variety of tumor cells, including breast cancer (Miller et al, 1998), head and neck cancer (Richards et al, 1997), melanoma (Norgauer et al, 1996), pancreatic (Takamori et al, 2000), and ovarian cancer (Venkatakrishnan et al, 2000), all cancers with high metastatic index. In addition, recent investigations have shown that activation of the CXCR2 expressed on microvascular endothelial cells is responsible for the angiogenic response to IL-8 (Addison et al, 2000;Schraufstatter et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway

et al. 2005

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The Kaposi's sarcoma herpesvirus encodes a G-proteincoupled chemokine receptor termed KSHV-GPCR. Expression of this constitutively active GPCR leads to cell transformation and vascular overgrowth characteristic of Kaposi's sarcoma. Previously, we have shown that CXCR2, the closest human homolog, is similarly able to transform cells if continuously stimulated or constitutively activated by amino-acid exchange D138V of the DRY sequence. Here, we demonstrate that STAT3 activation is a prerequisite for transformation in KSHV-GPCR and CXCR2 transfected NIH 3T3 cells. In KSHV-GPCR and D138V transfected cells, STAT-3 is constitutively phosphorylated on Tyr 705 . In CXCR2 transfected NIH 3T3 cells and human microvascular endothelial cells (HMEC), which express the CXCR2 constitutively, STAT3 is phosphorylated upon stimulation with IL-8 (CXCL8). Focus formation in NIH 3T3 cells transfected with the KSHV-GPCR, CXCR2, or the D138V mutant, was blocked by the specific JAK2 inhibitor AG490. Typical functions of the CXCR2 including actin stress fiber formation, haptotaxis, and the angiogenic response in HMEC shown by tube formation in Matrigel were blocked by AG490. These data suggest that the transforming capacity and migratory responses that are involved in tumor development, metastasis, and angiogenesis in KSHV or CXCR2-expressing cells is at least partially mediated through a JAK2-STAT3 dependent pathway.

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Coexpression of interleukin-8 receptors in head and neck squamous cell carcinoma

Cited by 92 publications

References 20 publications

Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1

Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1

Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice

KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway

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