Coexisting endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia

Abstract

A relatively high incidence of EC is seen in patients with a diagnosis of AEH. Diagnostic results of pipelle biopsy and curettage were comparable. Frozen sections of hysterectomy specimens does not guarantee to exclude the possibility of EC, especially in patients with no myometrial invasion.

Hysteroscopic Inspection and Total Curettage Are Insufficient for Discriminating Endometrial Cancer from Atypical Endometrial Hyperplasia

“…These results are similar to those in previous reports (Table 5) (Kurman and Norris 1982;Janicek and Rosenshein 1994;Lambert et al 1994;Hunter et al 1994;Liapis et al 1994;Widra et al 1995;Dunton et al 1996;Xie et al 2002;Agostini et al 2002;Kimura et al 2003;Bilgin et al 2004;Shutter and Wright 2005;Merisio et al 2005;Garuti et al 2006;Trimble et al 2006;Dordević et al 2007). Sampling errors Values are shown as a mean (± s.d.…”

Accuracy of Frozen Sections for Intraoperative Diagnosis of Complex Atypical Endometrial Hyperplasia

“…In the literature studies about the accuracy of FS are limited. Some studies reported low accuracy rate of FS (Bilgin et al, 2004;Indermaur et al, 2007).…”

Which Endometrial Pathologies Need Intraoperative Frozen Sections?

“…It is typically diagnosed by endometrial biopsy or curettage when a woman is noted as suffering from abnormal uterine bleeding particularly in older women. Endometrial hyperplasia is classified into 4 different categories: simple hyperplasia with or without cytological atypia and complex hyperplasia with or without cytological atypia (Bilgin et al, 2004;Indermaur et al, 2007). Atypical endometrial hyperplasia has been strongly associated with endometrial carcinoma.…”

“…Frozen section analysis of hysterectomy specimens in patients with atypical endometrial hyperplasia was found to be necessary to determine the presence of cancer and the need for surgical staging in a different study (Gundem et al, 2003). Bilgin et al (2004) reported that frozen section has a low accuracy rate to excluding the possibility of endometrial cancer in patients with preoperative diagnosis of CAEH (Bilgin et al, 2004). In several studies, it was reported that the underlying adenocarcinoma rate was 47.8% in patients with a preoperative diagnosis of CAEH (Lambert et al, 1994;Valenzuela et al, 2003).…”

“…Gulsah Balik*, Mehmet Kagitci, Isık Ustuner, Funda Akpinar, Emine Seda Guvendag Guven elevated risk of endometrial carcinoma (Bilgin et al, 2004). Endometrial polyp (EMP) is a common benign disease of the uterus.…”