Coexistent Lymphosarcoma and Chronic Granulocytic Leukemia.

Lymphosarcoma during the course of myeloid leukaemia

“…When 'lymphoma' complicates chronic myeloid leukaemia the leukaemia usually has been of the Philadelphia-negative type (Wilson & Van Slyck, 1966). Repeated attempts in the present case failed to produce satisfactory metaphase plates and we therefore cannot comment on this particular aspect of the problem from personal experience.…”

“…Acute leukaemia may be the terminal stage of reticulum cell sarcoma (Beutler, 1954;Zeffren & Ultmann, 1960), lymphosarcoma (Sternberg, 1916;Flashman & Leopold, 1929) or Hodgkin's disease (Skworzoff, 1930;Skworzoff & Kazantzeva, 1930). The association of chronic myeloid leukaemia with malignant lymphoma, however, remains rarely recorded; the complicating disease process has been reticulosarcoma (Hanns, Israel & Sacrez, 1934;Wilcken, 1957;Belotipetskaya & Gets, 1960, lymphosarcoma (Yang, 1936Forkner, 1938;Sardesai & Bhatia, 1959;Howell & Whitfield, 1963;Kurai & Papp, 1965;Wilson & van Slyck, 1966) and Hodgkin's disease (Samwick, Cohn & Swiller, 1955;Lacker & complicated by monocytic leukaemia (Craven, 1936). Usually the diagnosis of chronic myeloid leukaemia has been established prior to recognition of the complicating disease, but in the case of Wilson & Van Slyck, a 54-year-old man, lymphosarcoma occurred 2 years before chronic myeloid leukaemia was detected (see Table 1).…”

Concomitant presentation of two chronic leukemias: Evidence for independent clonal evolution

“…141 ,(2) rosettes with antibody-complement-treated sheep erythrocytes [ 151 , (3) mouse erythrocyte rosettes [ 161 , and (4) cell surface Ig pattern [ 171 . blood lymphocytes [ 181 were used.…”