Coexistent cutaneous T-cell lymphoma and B-cell malignancy

Grange, Florent; Avril, Marie-Françoise; Estève, É.; Joly, P.; Bosq, Jacques; Murets, Anne de; Thomine, E; Ortoli, J C; Duvillard, P.; Vaillant, L.; Bagot, Martine; Wechsler, Janine

doi:10.1016/s0190-9622(94)70232-2

Cited by 36 publications

(37 citation statements)

References 31 publications

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“…The coexistence in the same patient of mycosis fungoides, a peripheral T‐cell lymphoma, and B or plasma cell malignancies (B‐cell malignancies) is unusual. Most reports are case reports, and the largest series comprises only six patients 3–29 Table 3. summarizes the 36 previous cases reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides associated with B-cell malignancies

Barzilai

Trau

David

et al. 2006

British Journal of Dermatology

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This case series indicates that while the coexistence of Hodgkin's lymphoma and mycosis fungoides is extremely rare, the association of mycosis fungoides and B-cell malignancies is not as rare as reflected in the literature, with non-Hodgkin's lymphoma constituting the most common associated B-cell malignancy. In this series as well as in the cases reported in the literature mycosis fungoides usually preceded the development of B-cell malignancies, which may be in accordance with previous reports of an increased risk of developing a second haematological neoplasm. The importance of a competent immune system for patients with mycosis fungoides is well demonstrated in these cases. It is suggested that for greater precision the criteria for diagnosis of composite lymphoma of the skin should include both phenotypic and genotypic features.

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Section: Discussionmentioning

confidence: 99%

Mycosis fungoides associated with B-cell malignancies

Barzilai

Trau

David

et al. 2006

British Journal of Dermatology

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“…Various explanations for the coexistence of different lymphomas in an individual have been proposed (4,8), such as a genetic predisposition for malignancies (9). In our case, the patient's father had died of gastric cancer.…”

Section: Letters To the Editormentioning

confidence: 67%

Mycosis Fungoides with Recurrent Hodgkin’s Lymphoma and Diffuse Large B-cell Lymphoma

Miyagaki¹,

Sugaya²,

Minatani³

et al. 2009

Acta Derm Venerol

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SinMycosis fungoides (MF), a common form of primary ctitaneous T-cell lymphoma (CTCL), is a type of to nonHodgkin's lymphoma (HL). Although the coexistence of multiple distinct lymphoid neoplasms in the same itidividual is rare, cases of CTCL associated with HL or other types of non-Hodgkin's lymphoma have been described previously (1-3). We report here a rare case of MF associated with a composite recurrent HL and diffuse large B-cell lymphoma (DLBCL). CASE REPORTiA 75-year-oid Japatiese man was referred to our hospital with scaly erythematous plaques distributed over most of his body. The patient had a histoiy of nodular-sclerosing subtype HL diagnosed at the age of62 years with persistent fever and left axillary lymph node swelling. Biopsy specimens from axillary lymph nodes showed a pleomorphic cellular infiltróte with bands of fibrosis and contained nunieroiis large atypicul cells, including ReedStemberg cells and lacunar cells {Fig. la). Immunohistochemistry and in situ hybridization showed thai the Reed-Stcmbcrg cells were positive for CD30 and Epstein-Barr vims-encoded RNA (EBER) and negative for CD20. In addition. T-cell markers were negative. These features confirmed the diagnosis of nodularsclerosis subtype of HL. He was treated with polychemotherapy (cyclophosphamide, vincristine, procarbazine and prednisolone) combined with radiation therapy and complete remission was achieved. Mis medical history was otherwise unremarkable.At presentation, scaly erythematous patches and infiltrated plaques were distributed over most of ihe patient's body (Fig. 2a). The skin lesions had initially appeared at the age of 64 years on his left arm and the number of lesions increased year after year. He had no lymphadenopathy. Hislological examination of a skin biopsy specimen from the left shoulder revealed infiltration of small lymphocytes with only subtle nuclear atypia in the epidermis and superficial dennis (Fig. 2b). Immunohistochemieal study showed that these atypical cells were positive forCD3 and CD4., bul negative for CD20 and CD30. Southern blotting analysis of T-cell receptor gene using DNA from lesional skin detected a monoclonal rearrangement band. Further detailed examination revealed no visceral, lymph node, or blood involvement. The patient was diagnosed with MF. T2bNOMOIîO, clinical stage Ib.The skin lesions were treated with oral psoralen-ultraviolet A (PUVA) therapy and topical corticosteroid. resulting in partial improvement. The skin lesions remained stable thereafter. Three years after the diagnosis of MF. a subcutaneous mass (3.5x3.0 cm) appeared on the patient's left lower abdomen. He also developed swelling of multiple lymph nodes, ranging from the aortic bifurcation region to the bilateral inguinal region. Biop.sy specimens from the inguinal lymph nodes showed almost the same pathological findings as those from axillary lymph nodes at the age of 62 years (Fig. Ib). In addition, there was a lesion composed of diffuse infiltration of large-sized centroblasts(FÍg. le). Most large atypical lymphocyt...

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“…A thorough review of the literature on PubMed, using the search terms (“mycosis fungoides” OR “cutaneous T-cell lymphoma”) AND (leukemia OR leukaemia OR lymphoma OR “lymphoid malignancy” OR “Hodgkin's disease” OR “non-Hodgkin's disease” OR “multiple myeloma” OR “B-cell”), identified 68 cases of concomitant mycosis fungoides and a lymphoid malignancy [2, 4, 5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27]. Narrowing the results, we were able to find 5 cases of hairy cell leukemia along with mycosis fungoides reported [2, 5].…”

Section: Discussionmentioning

confidence: 99%

Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man

2017

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The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. B hairy cell leukemia and mycosis fungoides occurring in the same patient seems to be a rare phenomenon with only 5 cases reported in the literature.

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Coexistent cutaneous T-cell lymphoma and B-cell malignancy

Cited by 36 publications

References 31 publications

Mycosis fungoides associated with B-cell malignancies

Mycosis fungoides associated with B-cell malignancies

Mycosis Fungoides with Recurrent Hodgkin’s Lymphoma and Diffuse Large B-cell Lymphoma

Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man

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