Three patients with cutaneous T-cell lymphoma (CTCL) are reported who had concurrent B-cell chronic lymphocytic leukaemia (B-CLL). The separate lineage and clonal nature of the individual lymphoid malignancies were confirmed by gene-rearrangement analysis. The chronology of the illnesses did not support the hypothesis that CTCL predisposes to the development of B-cell proliferative disorders. There was no clear association with immunosuppressive therapy, and HTLV-1 studies were negative in all patients. Consequently, we speculate that a lymphoid stem cell defect, which may lead to the development of either aberrant B- or T-cell clones, may be responsible for such cases of dual lymphoid neoplasia.
Radial diffusivity profiles of atomized (MC, d = 1800 ± 200 µm) and inkjet-printed (MI, d = 40 ± 5 µm) alginate-based artificial cells have been generated using 2D Fluorescence Microscopy. The passive outward diffusion of FITC-Dextrans from MIs (0.5% LV alginate/15% CaCl2 coated with 0.5% Chitosan) and MCs (1.5% MV alginate/1.5% CaCl2) was measured and quantified using a Fickian model. As an expected outcome of miniaturization, the ratios of the outer layer diffusivities defined as D(MIout)/D(MCout) were 4.25 and 5.07 respectively for the 4 and 70 kDa markers, indicative of the enhanced diffusive potential of the miniaturized capsules.
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