Coexistence of two novel resistance plasmids, blaKPC-2-carrying p14057A and tetA(A) -carrying p14057B, in Pseudomonas aeruginosa

Shi, Lingen; Liang, Quanhui; Feng, Jiao; Zhan, Zhe; Zhao, Yachao; Yang, Wenhui; Yang, Huiying; Chen, Yong; Huang, Mei‐Rong; Tong, Yigang; Li, Xiaojun; Yin, Zhe; Wang, Jinglin; Zhou, Dongsheng

doi:10.1080/21505594.2017.1372082

Cited by 21 publications

(17 citation statements)

References 38 publications

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“…The accession number of each sequence is indicated in brackets . Arrows indicate open reading frames with filled colors that differ by function: yellow , transposition; orange , class 1 integrase; red , antimicrobial resistance; green , heavy metal resistance ( Radstrom et al, 1994 ; Minakhina et al, 1999 ; Shi et al, 2018 ).…”

Section: Mobile Genetic Elements Associated With Carbapenemase-encodimentioning

confidence: 99%

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

2021

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Carbapenem-resistant Pseudomonas aeruginosa is one of the major concerns in clinical settings impelling a great challenge to antimicrobial therapy for patients with infections caused by the pathogen. While membrane permeability, together with derepression of the intrinsic beta-lactamase gene, is the global prevailing mechanism of carbapenem resistance in P. aeruginosa, the acquired genes for carbapenemases need special attention because horizontal gene transfer through mobile genetic elements, such as integrons, transposons, plasmids, and integrative and conjugative elements, could accelerate the dissemination of the carbapenem-resistant P. aeruginosa. This review aimed to illustrate epidemiologically the carbapenem resistance in P. aeruginosa, including the resistance rates worldwide and the carbapenemase-encoding genes along with the mobile genetic elements responsible for the horizontal dissemination of the drug resistance determinants. Moreover, the modular mobile elements including the carbapenemase-encoding gene, also known as the P. aeruginosa resistance islands, are scrutinized mostly for their structures.

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Section: Mobile Genetic Elements Associated With Carbapenemase-encodimentioning

confidence: 99%

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

2021

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“…Likewise, the chromosomal bla GES-20 carbapenemase gene was identified in a study of hospital isolates of P. aeruginosa from Mexico [68]. Apart from GES family, and, although KPC is commonly detected in Enterobacteriaceae, reports of KPC-2 in P. aeruginosa are accumulating, including data from Germany [230], Brazil [231], China [232], and Puerto Rico [233]. The bla KPC gene is carried by plasmids, which suggests the possibility of an inter-genus spread from Enterobacteriaceae into non-fermenters, even though evidence of such a spread is still unclear [224].…”

Section: Pseudomonasmentioning

confidence: 99%

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

2020

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Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent the most potent β-lactamases, which hydrolyze a broad variety of β-lactams, including carbapenems, cephalosporins, penicillin, and aztreonam. The major issues associated with carbapenemase production are clinical due to compromising the activity of the last resort antibiotics used for treating serious infections, and epidemiological due to their dissemination into various bacteria across almost all geographic regions. Carbapenemase-producing Enterobacteriaceae have received more attention upon their first report in the early 1990s. Currently, there is increased awareness of the impact of nonfermenting bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, as well as other Gram-negative bacteria that are carbapenemase-producers. Outside the scope of clinical importance, carbapenemases are also detected in bacteria from environmental and zoonotic niches, which raises greater concerns over their prevalence, and the need for public health measures to control consequences of their propagation. The aims of the current review are to define and categorize the different families of carbapenemases, and to overview the main lines of their spread across different bacterial groups.

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“…The first classification of plasmids was based on incompatibility (Inc) groups (the mechanism that prevents the existence of plasmids with the same replication mechanism within the same bacterial cell); specific incompatibility groups were described in Enterobacteriaceae, Pseudomonas spp., and Gram-positive staphylococci (Frost et al, 2005). In MDR strains of P. aeruginosa, a series of plasmids (pS04 90, pBM41, p14057 A, and p14057 B) encoding carbapenemase resistance have been highlighted (Liu et al, 2018;Shi et al, 2018;van der Zee et al, 2018). Strains of A. baumannii show plasmid-encoded resistance to carbapenems (Cameranesi et al, 2018;Leungtongkam et al, 2018;Silva et al, 2018), aminoglycosides (armA) (Upadhyay et al, 2018), colistin (Jaidane et al, 2018), sulfonamides, or streptomycin (Hamidian et al, 2016).…”

Section: Plasmidsmentioning

confidence: 99%

“…In addition, plasmids conferring resistance to various classes of antibiotics have been found in Staphylococcus spp. (Mugnier et al, 2009;Ruiz-Martinez et al, 2011;Hamidian et al, 2016;Holmes et al, 2016;Liu et al, 2016Liu et al, , 2018Becker et al, 2018;Cameranesi et al, 2018;Fessler et al, 2018;Jaidane et al, 2018;Leungtongkam et al, 2018;Shi et al, 2018;Silva et al, 2018;Upadhyay et al, 2018;van der Zee et al, 2018). Resistance plasmids exhibit a high degree of plasticity, which is translated into an increased frequency of insertions, deletions, and changes in DNA (Kado, 2014).…”

Section: Plasmidsmentioning

confidence: 99%

Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance

et al. 2020

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Antimicrobial resistance (AMR) is a significant global threat to both public health and the environment. The emergence and expansion of AMR is sustained by the enormous diversity and mobility of antimicrobial resistance genes (ARGs). Different mechanisms of horizontal gene transfer (HGT), including conjugation, transduction, and transformation, have facilitated the accumulation and dissemination of ARGs in Gram-negative and Gram-positive bacteria. This has resulted in the development of multidrug resistance in some bacteria. The most clinically significant ARGs are usually located on different mobile genetic elements (MGEs) that can move intracellularly (between the bacterial chromosome and plasmids) or intercellularly (within the same species or between different species or genera). Resistance plasmids play a central role both in HGT and as support elements for other MGEs, in which ARGs are assembled by transposition and recombination mechanisms. Considering the crucial role of MGEs in the acquisition and transmission of ARGs, a potential strategy to control AMR is to eliminate MGEs. This review discusses current progress on the development of chemical and biological approaches for the elimination of ARG carriers.

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Coexistence of two novel resistance plasmids, bla_KPC-2-carrying p14057A and tetA(A) -carrying p14057B, in Pseudomonas aeruginosa

Cited by 21 publications

References 38 publications

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance

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