Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

Pattnaik, Naina; Rajguru, Jagadish Prasad; Pattanaik, Samarjeet J; Bardhan, Debajyoti; Nayak, Bikash; Islam, Mustaq Fizur

doi:10.4103/jfmpc.jfmpc_479_20

Cited by 9 publications

(15 citation statements)

References 28 publications

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“…Moreover, in this study female predilection is shown; posterior mandible is also the main occurring site accounting for 67% of the lesions. Female predilection cloud be related to positive influence of oestrogen and progesterone [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are various etiological factors for PGCG such as poor oral hygiene, food impaction, xerostomia, pregnancy, hormonal imbalance, and hyperparathyroidism (HPT) [ 1 , 17 ]. In cases of multiple lesions, both synchronous and metachronous, once removed classic irritating factors, clinicians should suspect hormonal imbalances.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of the PGCG is complete excision of the lesion along with the curettage of the base and borders of the lesion [ 23 ]. The recurrence rate of the lesion is 5.0–70.6% [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral giant cell granuloma (PGCG) is a benign, reactive, exophytic gingival lesion that accounts for less than 10% of all gingival lesions [ 1 ]. PGCG is usually found in adults with peak in incidence in the age group of 30–40 years [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are various etiological factors for PGCG such as poor oral hygiene, food impaction, previous dental extractions, xerostomia, hormonal imbalance such as hyperparathyroidism (HPT) [ 1 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Limongelli

Tempesta

Lauritano

et al. 2020

JCM

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Peripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo Moro University of Bari from 2009 to 2019. Surgical treatment consisted in conservative enucleation of the lesion, if possible, with contextual bone rim osteoplasty with piezosurgical tools and following histological examination. After histological diagnosis of PGCG, PHPT screening was performed dosing parathyroid hormone and serum calcium. In all the patients haematological investigation demonstrated elevated values of parathyroid hormone and serum calcium ruling out an unknown PHPT. Specifically, after endocrinological evaluation, patients showed PHPT related to: parathyroid adenoma (13), parathyroid hyperplasia (two, one of which occurred in a intra-thyroidal parathyroid), and parathyroid carcinoma (1) and were scheduled for surgical treatment. Considering that PGCGs could represent the first clinical sign of an undiagnosed PHPT and the screening of PHPT is a non-invasive and cheap exam, in case of histological diagnosis of a giant cell lesion, both central and peripheral, especially in patients with synchronous or history of methacronous giant cell lesions, parathyroidal screening should be mandatory.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The treatment of the PGCG is complete excision of the lesion along with the curettage of the base and borders of the lesion [ 23 ]. The recurrence rate of the lesion is 5.0–70.6% [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Limongelli

Tempesta

Lauritano

et al. 2020

JCM

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Peripheral giant cell granuloma as a sign of hyperparathyroidism in a patient under hemodialysis: A case report and review of literature

Yousefian,

Aghakouchakzadeh,

Torki

2023

Clinical Case Reports

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Key Clinical MessagePeripheral giant cell granuloma (PGCG) is a benign reactive exophytic oral lesion that originates from the periosteum or the periodontal ligament. It exclusively develops on the gingiva or alveolar mucosa. Hyperparathyroidism (HPT) is a possible etiology for its development. HPT is an endocrine disorder characterized by increased secretion of the parathyroid hormone (PTH). This case report describes a case of recurring PGCG in a patient diagnosed with secondary HPT after paraclinical assessment.

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Mucosal Soft Tissue Lesions

Philipone,

Yoon

2023

Pediatr Dev Pathol

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Mucosal soft tissue lesions are fairly common in the pediatric population. However, the precise prevalence is unknown. This is the result of the limited number of studies, the use of various diagnostic criteria in those studies, and the transient nature of commonly encountered lesions in this population. In this section, we seek to familiarize the pediatric pathologist with a sampling of mucosal soft tissue lesions encountered in pediatric patients, highlight key diagnostic features and correlations with systemic diseases should they exist.

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Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

Cited by 9 publications

References 28 publications

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Peripheral giant cell granuloma as a sign of hyperparathyroidism in a patient under hemodialysis: A case report and review of literature

Mucosal Soft Tissue Lesions

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