Coexistence of Gallbladder Agenesis and Cholangiocarcinoma: Report of a Case

Yoldaş, Ömer; Yazici, Pınar; Özsan, İsmail; Karabuğa, Türker; Alpdoğan, Özcan; Şahin, Erkan Melih; Ünal, Aydın

doi:10.1007/s11605-014-2472-x

Cited by 6 publications

(20 citation statements)

References 20 publications

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“…They suggested that bile stasis may have caused chronic inflammation of the bile duct and this resulted in biliary neoplasm 13. A cholangiocarcinoma has also been reported in a patient with GA 14. We were faced with a therapeutic dilemma for this case.…”

Section: Discussionmentioning

confidence: 90%

Association between gallbladder agenesis and choledochal cyst: cause or coincidence?

et al. 2019

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This case report describes an extremely rare association between gallbladder agenesis and choledochal cyst (CC). A 9-year-old girl presented with recurrent abdominal pain in the right upper quadrant. Radiological studies revealed a CC type IVa and an agenesis of gallbladder and cystic duct. Due to the possibility of biliary neoplasm, the patient underwent cyst resection and hepaticoduodenostomy. Histopathological findings showed inflamed fibrous tissue covered by biliary epithelium with no evidence of malignancy.

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Section: Discussionmentioning

confidence: 90%

Association between gallbladder agenesis and choledochal cyst: cause or coincidence?

et al. 2019

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“…Moreover, the gallbladder may appear absent due to inappropriate migration of the gallbladder primordium; subsequently resulting in ectopic gallbladder that may be located in intrahepatic space. 3 , 4 …”

Section: Discussionmentioning

confidence: 99%

Recurrent pancreatitis in the setting of gallbladder agenesis, ansa pancreatica, Santorinicoele and eventual intraductal papillary mucinous neoplasia (IPMN)

Lee

Davidson

Kia

et al. 2020

Ann Hepatobiliary Pancreat Surg

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Gallbladder agenesis is a rare condition. Patients with gallbladder agenesis can present with biliary type symptoms and rarely pancreatitis. We present the case of a 35-year-old gentleman who was admitted and treated for recurrent pancreatitis on a background of gallbladder agenesis, ansa pancreatica and Santorinicoele. He has had several admissions with pancreatitis and has had multiple imaging modalities during these admissions which we delineate. We discuss this rare anatomical variant and describe the course and management of his illness leading up to his eventual diagnosis of intraductal papillary neoplasia (IPMN).

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“…Gallbladder agenesis is an anomaly that results from the failure of budding of the gallbladder and cystic duct from the common bile duct during the fourth and fifth weeks of embryogenesis (1). The first case reports were published in 1701 by Lemery and Bergman (2).…”

Section: Epidemiologymentioning

confidence: 99%

“…Hence, in a number of cases of symptomatic GBA, the diagnosis is made intraoperatively (4). Congenital defects often associated with GBA include cardiac, gastrointestinal, and genitourinary abnormalities such as duodenal atresia, intestinal malrotation, pancreas divisum, imperforate anus, hypoplasia of the right hepatic lobe, duplication cysts of the hepatic flexure, ventricular septal defect, renal agenesis, undescended testes, and syndactyly (1,3). It can also be associated with genetic syndromes such as trisomy 18 (1).…”

Section: Presentationmentioning

confidence: 99%

Agenesis of the Gallbladder: A Phantom Menace

Nadeau

Jiang²,

Paradis³

2018

UOJM

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Objective: Gallbladder agenesis (GBA) is a rare congenital disorder with an estimated incidence of about 0.06%. Despite the absence of a gallbladder, these patients may present with symptoms mimicking biliary colic or cholecystitis. Ultrasound findings and liver function tests are often misleading. Some of these patients undergo laparoscopy without successful identification of gallbladder and paradoxically report symptom relief. Case: We present a case of GBA in a 54 year-old female, who presented with right-sided abdominal pain. The clinical history and examination were consistent with biliary colic. Initial investigations, including liver function tests, upper endoscopy and ultrasound did not demonstrate upper gastrointestinal pathology and did not clearly identify a gallbladder. Subsequent HIDA scan and CT of the abdomen did not visualize a gallbladder. An MRCP confirmed gallbladder agenesis. The patient was managed conservatively and was symptom free on discharge and follow-up. Discussion: We wish to highlight four learning points: 1. Patients with gallbladder agenesis often present with biliary symptoms. 2. Ultrasound and CT of the liver may not always identify this anomaly. 3. MRCP is the gold standard for making a diagnosis of gall- bladder agenesis. 4. Surgeons must have a high index of suspicion of GBA when the gallbladder is poorly visualized or not identified on ultrasound.

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Coexistence of Gallbladder Agenesis and Cholangiocarcinoma: Report of a Case

Cited by 6 publications

References 20 publications

Association between gallbladder agenesis and choledochal cyst: cause or coincidence?

Association between gallbladder agenesis and choledochal cyst: cause or coincidence?

Recurrent pancreatitis in the setting of gallbladder agenesis, ansa pancreatica, Santorinicoele and eventual intraductal papillary mucinous neoplasia (IPMN)

Agenesis of the Gallbladder: A Phantom Menace

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