Coexistence of ankylosing spondylitis and rheumatoid arthritis in a female patient

Abstract

Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are two distinguished representatives of inflammatory rheumatic diseases. The two diseases differ significantly in their etiology, pathology, clinical signs, and in the nature of articular manifestations. Their association has been a rarity in the literature. Here, authors describe a case of a 55-year-old female patient with AS associated with RA. Her spinal symptoms started in 1979, and the diagnosis of AS was established based on the typical clinical picture and X-ray. She developed severe spinal deformity during the next decades. In 2005, peripheral polyarthritis developed, although neither the diagnosis nor the treatment was modified. In 2007, authors diagnosed seropositive RA. Therapy included anti-inflammatory therapy and traditional disease-modifying agents, eventually followed by biological therapy.

Síndrome de overlap: uma revisão de literatura da associação entre artrite reumatoide, espondilite anquilosante e síndrome de Sjögren

“…Foram prescritos DMARDs, leflunomida e hidroxicloroquina (Guo et al, 2011). Baksay et al (2011) descreve o caso de uma mulher que, aos 25 anos, alguns meses após conceber seu filho, desenvolveu dor e rigidez de coluna cervical, tendo o diagnóstico de espondilite anquilosante confirmado alguns anos depois.…”

“…Metilprednisolona e metotrexato foram prescritos (Baksay et al, 2011 (Varga et al, 2009). Toussirot e Acquaviva (1995) conduziram um estudo retrospectivo com o objetivo de determinar a frequência da positividade do HLA-B27 em pacientes portadores de artrite reumatoide hospitalizados durante os últimos 5 anos em um hospital da França (n = 130).…”

Coexistence of rheumatoid arthritis and ankylosing spondylitis

“…In connection with the secondary ineffectiveness of anti-TNF, the patient was qualified for tocilizumab treatment. In most patients with RA coexisting with AS described during the last decade, biological treatment with TNF was administered [ 17 , 18 ].…”

“…The authors assume that pregnancy might be one of the environmental factors affecting the disclosure of both diseases in individuals with a positive HLA-B27 and HLA-DR4. They also state that until 1998, a total of 60 cases with coexistence of RA and AS had been described and another were reported between 2011 and 2014 [ 17 – 19 ].…”

Combination of ankylosing spondylitis and rheumatoid arthritis: clinical observations and literature review

“…В генотипе наших пациентов присутствовал HLA-B27, определение которого в последние годы стало рутинным тестом, в то время как антигены локуса HLA-DR в обычной практике исследуются редко. У пациентов, представленных в литературе, отмечалось сочетание HLA-B27 и HLA-DR4 [31,32].…”