Coenzyme Q10: The essential nutrient

Saini, Rajiv

doi:10.4103/0975-7406.84471

Cited by 135 publications

(92 citation statements)

References 3 publications

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“…It is contained in some foods, its dosage in blood is feasible, and its deficiency is associated with some diseases, while its supplementation tends to restore a physiological condition (Table 2). Moreover, the supplementation with CoQ 10 is safe, even with chronic exposure to 900 mg/day [175] and in frail patients, like elderly and CKD patients, without any known pharmacological interactions [3]. The results derived from clinical trials testing the efficacy of CoQ 10 supplementation in different settings are often contrasting and complicate the process of making definitive conclusion on its efficacy in a number of conditions.…”

Section: Discussionmentioning

confidence: 99%

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Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy transfer molecule but could be reduced by aging, genetic factors, drugs (e.g., statins), cardiovascular (CV) diseases, degenerative muscle disorders, and neurodegenerative diseases. As CoQ10 is endowed with significant antioxidant and anti-inflammatory features, useful to prevent free radical-induced damage and inflammatory signaling pathway activation, its depletion results in exacerbation of inflammatory processes. Therefore, exogenous CoQ10 supplementation might be useful as an adjuvant in the treatment of cardiovascular diseases such as heart failure, atrial fibrillation, and myocardial infarction and in associated risk factors such as hypertension, insulin resistance, dyslipidemias, and obesity. This review aims to summarize the current evidences on the use of CoQ10 supplementation as a therapeutic approach in cardiovascular diseases through the analysis of its clinical impact on patients’ health and quality of life. A substantial reduction of inflammatory and oxidative stress markers has been observed in several randomized clinical trials (RCTs) focused on several of the abovementioned diseases, even if more RCTs, involving a larger number of patients, will be necessary to strengthen these interesting findings.

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Section: Discussionmentioning

confidence: 99%

“…This molecule can sustain continuous oxidation-reduction cycles and is an excellent electron carrier. CoQ 10 concentration is particularly high in organs such as the kidneys, heart, and liver (Table 1) because they need it as an efficient energy transfer molecule supporting their high metabolic rate [3]. Table 1.…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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“…[1,2] Coenzyme Q10 (CoQ10, ubiquinol-10 or ubiquinone-10) is a fat-soluble vitamin-like structure which can be found in every cell and it function as a coenzyme in the key enzymatic steps during cellular energy production. [3] It shows antioxidant properties by interfering with oxygen-derived radicals and singlet oxygen to prevent lipid peroxidation and damage of biomolecules. [4] Selenium reduces the activity of hydroperoxidase and lipoperoxidase via its glutathione peroxidase-like activity.…”

Section: Introductionmentioning

confidence: 99%

The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction

Kırdağ

Tuglu

Yuvanç

et al. 2019

Turkish Journal of Urology

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Objective: In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model. Material and methods: A total of 24 Sprague-Dawley rats were divided into four groups as Group 1 Control Group, Group 2, PUUO Group, Group 3 PUUO + coenzyme Q group, Group 4 PUUO + selenium group. Paraoxonase (PON), total antioxidant capacity (TAC), and total oxidant levels (TOS) were analyzed biochemically from tissue and blood samples. Tissue samples were examined histopathologically. Results: The TAC in the tissues was found to be statistically significantly increased in Groups 3 and 4, compared to Group 2. Tissue TOS was found to be significantly reduced in Groups 3 and 4, compared to Group 2. Serum PON levels were significantly increased in Group 3 and 4, compared to Group 1 and 2. Histopathological examination showed that interstitial inflammation and congestion were lesser in the coenzyme Q and selenium groups than in the PUUO group. A more significant decrease was found in the selenium group than in the coenzyme Q group. Conclusion: Our study results showed that coenzyme Q and selenium reduced the oxidation and the damage in tissue in PUUO in rats.

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“…Ominously, this is the similar alley in which the body usages to engender coenzyme Q10 (CoQ10). CoQ10 plays a significant role in boosting energy, augments the immune system and acts as significant lipid antioxidants [11]. Studies demonstrated that the blood levels of CoQ10 abated by 40 to 50 percent owing to 1 or 2 months statin therapy and this decline harmfully affects entire system of the body [12].…”

Section: Editorialmentioning

confidence: 99%