Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

Abstract

CoQ10 supplementation at a dosage of 500 mg appears to decrease the inflammatory markers (TNF-α, IL-6, and MMP-9) in patients with MS.

RETRACTED ARTICLE: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome

“…In another study, CoQ10 supplementation significantly reduced the IL-6 protein and TGF-b1 and Lep mRNA levels [6]. In addition, our study was in agreement with findings in cardiac tissue [23], and CoQ10 is known to have anti-inflammatory properties in mouse liver [24] and human plasma [25]. Also, gene expression of TNF-a were significantly decreased following CoQ10 intake in an experimental model of multiple sclerosis for three weeks [26].…”

Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

“…Lee et al found that 12 weeks of CoQ10 supplementation at a dosage of 300 mg/day significantly reduced serum levels of TNF-a in patients with coronary artery disease [26]. In another study, Sanoobar et al showed the significant effect of oral CoQ10 supplementation (500 mg/day) on IL-6 and TNF-a in patients with multiple sclerosis [28]. In contrast to our study, a 200 mg/day dose of CoQ10 for 8 weeks had no effect on hs-CRP levels in patients with diabetes [16].…”

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

“…The endogenous production of coenzyme Q10 declines after the age of 20, and at the age of 80, only half of endogenous production can be found in the heart [40]. Substantial efforts have been done in numerous studies where supplementation of coenzyme Q10 has been evaluated in different conditions, like multiple sclerosis [41,42] , in Parkinson´s disease [43], in patients with renal injury treated with shockwave lithotripsy [44], in male infertility [45], and in heart disease but with inconsistent results [46][47][48]. Fotino et al reported in a meta-analysis consisting of 13 studies and 395 patients increased cardiac function after coenzyme Q10 supplementation even if the total study sample was small [49].…”