Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Farsi, Farnaz; Mohammadshahi, Majid; Alavine­jad, Pezhman; Rezazadeh, Afshin; Zarei, Mehdi; Engali, Kambiz Ahmadi

doi:10.1080/07315724.2015.1021057

Cited by 91 publications

(70 citation statements)

References 36 publications

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“…At the end of the study, the active group benefited from a significant decrease in aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), tumor necrosis factor α, high-sensitivity C-reactive protein (hs-CRP), and NAFLD grade compared to placebo (p < 0.05 for all). In addition, patients who received the CoQ 10 supplement had higher serum levels of adiponectin (p = 0.016) even if serum leptin levels reduced marginally (p = 0.053) [53]. However, CoQ 10 administration (300 mg/day for 12 weeks) in patients with coronary artery disease did not find any significant effect on serum adiponectin levels [54], confirming previous data obtained by Gokbel et al with the supplementation of CoQ 10 100 mg/day in healthy volunteers [55].…”

Section: Insulin-resistance and Type 2 Diabetesmentioning

confidence: 99%

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy transfer molecule but could be reduced by aging, genetic factors, drugs (e.g., statins), cardiovascular (CV) diseases, degenerative muscle disorders, and neurodegenerative diseases. As CoQ10 is endowed with significant antioxidant and anti-inflammatory features, useful to prevent free radical-induced damage and inflammatory signaling pathway activation, its depletion results in exacerbation of inflammatory processes. Therefore, exogenous CoQ10 supplementation might be useful as an adjuvant in the treatment of cardiovascular diseases such as heart failure, atrial fibrillation, and myocardial infarction and in associated risk factors such as hypertension, insulin resistance, dyslipidemias, and obesity. This review aims to summarize the current evidences on the use of CoQ10 supplementation as a therapeutic approach in cardiovascular diseases through the analysis of its clinical impact on patients’ health and quality of life. A substantial reduction of inflammatory and oxidative stress markers has been observed in several randomized clinical trials (RCTs) focused on several of the abovementioned diseases, even if more RCTs, involving a larger number of patients, will be necessary to strengthen these interesting findings.

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Section: Insulin-resistance and Type 2 Diabetesmentioning

confidence: 99%

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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“…A randomised controlled trial by Farhangi et al 35 found supplementation with CoQ10 (100 mg/day for 4 weeks) resulted in decreased systemic levels of biochemical markers of inflammation and oxidative stress. In a more recent randomised controlled trial, 36 NAFLD patients given 100 mg CoQ10 per day for 3 months showed significant reductions in the levels of blood markers for liver inflammation and damage (aspartate aminotransferase, gammaglutamyl peptidase, C-reactive protein).…”

Section: Coq10 Diabetes and Liver Diseasementioning

confidence: 99%

Coenzyme Q10 supplementation for diabetes and its complications: an overview

Mantle¹

2017

Br J Diabetes

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This article reviews the potential role of dietary supplementation with coenzyme Q10 (CoQ10) for the management of patients with type 2 diabetes. The rationale for supplementation with CoQ10 is based on its key roles in cellular energy metabolism and as an antioxidant, and its potential mediation of oxidative stress and inflammation, which have been implicated in the pathogenesis of diabetes. Randomised controlled clinical trials have demonstrated that supplementation with CoQ10 can significantly improve glycaemic control, as well as improving vascular dysfunction. Supplementation with CoQ10 may be of particular importance in type 2 diabetics prescribed statins and in those with fatty liver disease. Supplemental CoQ10 is usually well tolerated, with no significant adverse effects reported in long-term use. The importance of product quality and bioavailability cannot be over-emphasised, since this may be a factor in the disparity of findings from clinical trials supplementing CoQ10.

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“…The two groups had similar age, BMI, and consumed the same type of glucose and lipid-lowering drugs. The dosage that was used in this study has no side effects as per previous study 17 . Every two weeks, patients were called to remind them about the consumption the supplements.…”

Section: Methodsmentioning

confidence: 98%

“…The lipid ratios including TG/HDL-C, TC/ HDL-C, LDL-C/HDL-C, HDL ratio and atherogenic index of plasma (AIP) have predictive values for developing the risk of CVD in T2DM 13,14 . Since CoQ10 has positive effects on insulin resistance 15 , insulin sensitivity, lipid metabolism and dyslipidemia, some studies have suggested using glucose-lowering drugs and CoQ10 together to control levels of lipids and thus to prevent the side effects of the drugs effectively 14,16,17 . The positive effects of CoQ10 on the lipid profile have been reported in animal 18,19 and human 8,20,21 studies and reported results of the effects of CoQ10 on the lipid ratios are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 supplementation effects on lipid ratios in women with type 2 diabetes mellitus: A randomized, double-blind clinical trial study

Zarei¹,

Rezvanfar²,

Khosrowbeygi³

2019

Bangladesh J Med Sci

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Objective: This study had been designed to evaluate the effects of Coenzyme Q10 (CoQ10) supplementation on the lipid ratios in women with type 2 diabetes mellitus (T2DM). Materials and Methods: Sixty-eight women with T2DM were enrolled and randomly divided into two groups. While one group received 100 mg/day of CoQ10 supplement for 12 weeks (n=34) the other was given placebo for the same time duration (n=34). Lipid profile including triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were evaluated at the beginning and at the end of the intervention and lipid ratios were calculated. Results and Discussion: After the intervention, values of non-HDL-C (p=0.001), TG/HDL-C (p=0.03) and LDL-C/HDL-C (p=0.001) were significantly decreased in CoQ10 group. Values of HDL ratio (p=0.002) were increased significantly in CoQ10 group. Conclusion: This study showed that daily supplementation with 100 mg of CoQ10 in women with T2DM could improve some atherogenic lipid ratios that might be useful in preventing cardiovascular diseases in them. Bangladesh Journal of Medical Science Vol.19(1) 2020 p.152-158

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Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Abstract: The present study suggested that CoQ10 supplement at a dosage of 100 mg could be effective for improving the systemic inflammation and biochemical variables in NAFLD.

Cited by 91 publications

References 36 publications

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

Coenzyme Q10 supplementation for diabetes and its complications: an overview

Coenzyme Q10 supplementation effects on lipid ratios in women with type 2 diabetes mellitus: A randomized, double-blind clinical trial study

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