Coenzyme Q10 in essential hypertension

Digiesi, V.; Cantini, Fabrizio; Oradei, A.; Bisi, G; Guarino, G; Brocchi, A; Bellandi, Francesco; Mancini, Mario; Littarru, G. P.

doi:10.1016/0098-2997(94)90036-1

Cited by 95 publications

(77 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coenzyme Q 10 in type 2 diabetes JM Hodgson et al viously reported Singh et al, 1999;Yamagami et al, 1986;Digiesi et al, 1990), but subjects involved in this study had blood pressures at baseline that were not in the hypertensive range where benefits may be more obvious. Therefore, the results of our study in type 2 diabetics are consistent, although less pronounced than those of previous studies in subjects with hypertension, and suggest that CoQ has the potential to lower blood pressure.…”

Section: Discussionmentioning

confidence: 79%

“…Previous controlled intervention studies in humans involving small numbers suggest that CoQ supplementation can lower blood pressure in subjects with uncontrolled or poorly controlled hypertension (Singh et al, 1999;Yamagami et al, 1986;Digiesi et al, 1990). In all these studies, where subjects had blood pressures at baseline of > 160=95, both systolic and diastolic blood pressure fell significantly.…”

Section: Discussionmentioning

confidence: 96%

“…Yamagami et al (1986) found that CoQ resulted in a fall in blood pressure of 19=6 mmHg in 20 subjects who received 100 mg=day of CoQ or placebo for 12 weeks in a parallel designed study. Digiesi et al (1990) found that CoQ resulted in a fall in blood pressure of 11=8 mmHg in 18 subjects who received 100 mg=day CoQ or placebo in a 10-week crossover study. In another study, where 59 hypertensive subjects received 120 mg=day CoQ or placebo for 8 weeks, CoQ resulted in a fall in blood pressure of 15=9 mmHg (Singh et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Several controlled intervention studies involving hypertensive patients have found that CoQ can lower blood pressure appreciably Singh et al, 1999;Yamagami et al, 1986;Digiesi et al, 1990). The effect of CoQ on blood pressure in diabetic subjects has not been explored.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes

et al. 2002

View full text Add to dashboard Cite

Objective: Our objective was to assess effects of dietary supplementation with coenzyme Q 10 (CoQ) on blood pressure and glycaemic control in subjects with type 2 diabetes, and to consider oxidative stress as a potential mechanism for any effects. Subjects and design: Seventy-four subjects with uncomplicated type 2 diabetes and dyslipidaemia were involved in a randomised double blind placebo-controlled 2Â2 factorial intervention. Setting: The study was performed at the University of Western Australia, Department of Medicine at Royal Perth Hospital, Australia. Interventions: Subjects were randomly assigned to receive an oral dose of 100 mg CoQ twice daily (200 mg=day), 200 mg fenofibrate each morning, both or neither for 12 weeks. Main outcome measures: We report an analysis and discussion of the effects of CoQ on blood pressure, on long-term glycaemic control measured by glycated haemoglobin (HbA 1c ), and on oxidative stress assessed by measurement of plasma F 2 -isoprostanes. Results: Fenofibrate did not alter blood pressure, HbA 1c , or plasma F 2 -isoprostanes. There was a 3-fold increase in plasma CoQ concentration (3.4 AE 0.3 mmol=l, P < 0.001) as a result of CoQ supplementation. The main effect of CoQ was to significantly decrease systolic ( 7 6.1 AE 2.6 mmHg, P ¼ 0.021) and diastolic ( 7 2.9 AE 1.4 mmHg, P ¼ 0.048) blood pressure and HbA 1c ( 7 0.37 AE 0.17%, P ¼ 0.032). Plasma F 2 -isoprostane concentrations were not altered by CoQ (0.14 AE 0.15 nmol=l, P ¼ 0.345). Conclusions: These results show that CoQ supplementation may improve blood pressure and long-term glycaemic control in subjects with type 2 diabetes, but these improvements were not associated with reduced oxidative stress, as assessed by F 2 -isoprostanes.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes

et al. 2002

View full text Add to dashboard Cite

show abstract

“…With one exception all these studies found that Q 10 supplementation decreased blood pressure. (Yamagami et al, 1986); Digiesi et al, 1990). Both systolic and diastolic blood pressure were reduced.…”

Section: Hypertensionmentioning

confidence: 97%