Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes

Abstract

Objective: Our objective was to assess effects of dietary supplementation with coenzyme Q 10 (CoQ) on blood pressure and glycaemic control in subjects with type 2 diabetes, and to consider oxidative stress as a potential mechanism for any effects. Subjects and design: Seventy-four subjects with uncomplicated type 2 diabetes and dyslipidaemia were involved in a randomised double blind placebo-controlled 2Â2 factorial intervention. Setting: The study was performed at the University of Western Australia, Department of Medicine at Royal Perth Hospital, Australia. Interventions: Subjects were randomly assigned to receive an oral dose of 100 mg CoQ twice daily (200 mg=day), 200 mg fenofibrate each morning, both or neither for 12 weeks. Main outcome measures: We report an analysis and discussion of the effects of CoQ on blood pressure, on long-term glycaemic control measured by glycated haemoglobin (HbA 1c ), and on oxidative stress assessed by measurement of plasma F 2 -isoprostanes. Results: Fenofibrate did not alter blood pressure, HbA 1c , or plasma F 2 -isoprostanes. There was a 3-fold increase in plasma CoQ concentration (3.4 AE 0.3 mmol=l, P < 0.001) as a result of CoQ supplementation. The main effect of CoQ was to significantly decrease systolic ( 7 6.1 AE 2.6 mmHg, P ¼ 0.021) and diastolic ( 7 2.9 AE 1.4 mmHg, P ¼ 0.048) blood pressure and HbA 1c ( 7 0.37 AE 0.17%, P ¼ 0.032). Plasma F 2 -isoprostane concentrations were not altered by CoQ (0.14 AE 0.15 nmol=l, P ¼ 0.345). Conclusions: These results show that CoQ supplementation may improve blood pressure and long-term glycaemic control in subjects with type 2 diabetes, but these improvements were not associated with reduced oxidative stress, as assessed by F 2 -isoprostanes.

Effect of Coenzyme Q 10 on Blood Glucose Level in Streptozotocin Induced Diabetic Rats

“…In a randomized trial Hodgson et al (2002) found modest improvement in A1C level by this drug in 200mg dose once daily in 12 weeks period which also support the result achieved in this experiments. …”

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

“…This increase in the serum sodium level due to CoQ10 supplementation is attributed to the protective effect and electrolyte retention by CoQ10 on the kidney tissue (Aly, 2012). Broilers fed CoQ10 had lower blood glucose level which was reported to be due to improvement in the β-cell functions which enhances insulin sensitivity and could reduce the insulin requirement for diabetic patients (Hodgson et al, 2002). Low or deficient level of CoQ10 was reported in diabetes mellitus type II patients.…”

Relative Bioavailability of Coenzyme Q10 in Emulsion and Liposome Formulations

“…CoQ10 supplementation has also been reported to restore plasma CoQ10 levels in patients receiving statin therapy for the treatment of dyslipidemia (Laaksonen et al, 1994;Sassi et al, 1994;Young et al, 2007). Recently, CoQ10 is gaining popularity as a supplement that may help in the treatment of various other diseases such as oncologic and endocrinologic disorders (Hodgson et al, 2002;Roffe et al, 2004;Conklin, 2005;Ratnam et al, 2006). CoQ 10 has poor stability against light and very poor solubility in water.…”