Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy

Abstract

We aimed to determine the effect of supplementation with coenzyme Q10 on conventional therapy of children with cardiac failure due to idiopathic dilated cardiomyopathy. In a prospective, randomized, double-blinded, placebo-controlled trial, we randomized 38 patients younger than 18 years with idiopathic dilated cardiomyopathy to receive either coenzyme Q10, chosen for 17 patients, or placebo, administered in the remaining 21. Echocardiographic systolic and diastolic function parameters were determined for every patient at baseline, and after 6 months of supplementation. The index score for cardiac failure in children as established in New York was used for assessing the functional class of the patients. After 6 months supplementation, 10 patients randomized to receive coenzyme Q10 showed improvements in the grading of diastolic function, this being significantly more than that achieved by those randomized to the placebo group (p value = 0.011). The mean score for the index of cardiac failure index for those receiving coenzyme Q10 was also lower than the control group (p value = 0.024).Our results, therefore, indicate that administration of coenzyme Q10 is useful in ameliorating cardiac failure in patients with idiopathic dilated cardiomyopathy through its significant effect on improving diastolic function.

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

“…[8][9][10] It has also been reported that CoQ 10 has a hypotensive effect. 7,11,12) In addition, a number of people who usually intake CoQ 10 as a supplement also receive some kinds of drugs to treat high blood pressure.…”

“…CoQ 10 is a fat-soluble, vitamin-like benzoquinone compound that functions primarily as an antioxidant, a membrane stabilizer, and a cofactor in the oxidative phosphorylation process that leads to the production of adenosine triphosphate (ATP) in its reduced form. [1][2][3] CoQ 10 is widely consumed as a food supplement because of its status as an important nutrient for maintaining human health. The rationale for the use of CoQ 10 as a medical agent for treating cardiovascular diseases is based on its fundamental role in mitochondrial function and cellular bioenergetics.…”

“…There are numerous studies on the therapeutic efficacy of CoQ 10 sup-plementation in human subjects. [5][6][7] However, very little information regarding the interaction between CoQ 10 and drugs in medical use is available.…”

“…CoQ 10 was originally found to be effective in treating cardiovascular disorders such as cardiomyopathy, angina pectoris, and atherosclerosis. [8][9][10] It has also been reported that CoQ 10 has a hypotensive effect.…”

Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies

“…CoQ10 has been reported to have beneficial effects on the heart, lungs, liver, and skin. 1,2 It has been shown that by lowering matrix metalloproteinase levels in fibroblasts, CoQ10 reduces wrinkles. 3 CoQ10 also exerts anti-inflammatory effects on dermal fibroblasts.…”