Coenzyme Q10 for heart failure

Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

“…Meanwhile, coenzyme Q10 did not significantly improve the NYHA cardiac function in patients with heart failure, which is consistent with the results of a previous examination [29]. In this study, we found that coenzyme Q10 can improve exercise tolerance in patients with heart failure; however, in the investigation conducted by Madmani [30], this improvement was not statistically significant.…”

Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

“…Meanwhile, coenzyme Q10 did not significantly improve the NYHA cardiac function in patients with heart failure, which is consistent with the results of a previous examination [29]. In this study, we found that coenzyme Q10 can improve exercise tolerance in patients with heart failure; however, in the investigation conducted by Madmani [30], this improvement was not statistically significant.…”

The Role of Coenzyme Q10 in Cardiovascular Disease Treatment: An Updated 2024 Systematic Review and Meta-Analysis of Prospective Cohort Studies (1990-2024)

“…The primary outcome, ejection fraction, showed a notable increase, indicating an enhancement in systolic performance. This finding aligns with previous studies suggesting that CoQ10 plays a crucial role in improving cardiac function by enhancing mitochondrial energy production and reducing oxidative stress [3,4,7,8,15].…”

“…Both fixed-effect and random-effects models provided similar effect sizes and confidence intervals, reinforcing the consistency of the results [3, 4, 7, 8, 11, 15].…”

“…Sensitivity analyses confirmed the robustness of these results, as excluding high-risk studies and using alternative statistical models did not significantly alter the outcomes [3, 4, 7, 8, 11, 15]. Publication bias was assessed and found to be low, further supporting the credibility of these findings [20, 21, 22, 23, 24].…”

“…The funnel plot, a scatter plot of effect sizes against their standard errors, was visually inspected for asymmetry. In this analysis, the funnel plot did not show significant asymmetry, suggesting a low risk of publication bias [20, 21, 22, 23, 24].…”

Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

“…Meanwhile, coenzyme Q10 did not significantly improve the NYHA cardiac function in patients with heart failure, which is consistent with the results of a previous examination [29]. In this study, we found that coenzyme Q10 can improve exercise tolerance in patients with heart failure; however, in the investigation conducted by Madmani [30], this improvement was not statistically significant.…”

The Role of Coenzyme Q10 in Cardiovascular Disease Treatment: An Updated 2024 Systematic Review and Meta-Analysis of Prospective Cohort Studies (1990-2024)

“…The primary outcome, ejection fraction, showed a notable increase, indicating an enhancement in systolic performance. This finding aligns with previous studies suggesting that CoQ10 plays a crucial role in improving cardiac function by enhancing mitochondrial energy production and reducing oxidative stress [3,4,7,8,15].…”

“…Both fixed-effect and random-effects models provided similar effect sizes and confidence intervals, reinforcing the consistency of the results [3, 4, 7, 8, 11, 15].…”

“…Sensitivity analyses confirmed the robustness of these results, as excluding high-risk studies and using alternative statistical models did not significantly alter the outcomes [3, 4, 7, 8, 11, 15]. Publication bias was assessed and found to be low, further supporting the credibility of these findings [20, 21, 22, 23, 24].…”

“…The funnel plot, a scatter plot of effect sizes against their standard errors, was visually inspected for asymmetry. In this analysis, the funnel plot did not show significant asymmetry, suggesting a low risk of publication bias [20, 21, 22, 23, 24].…”

Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

“…Meanwhile, coenzyme Q10 did not significantly improve the NYHA cardiac function in patients with heart failure, which is consistent with the results of a previous examination [29]. In this study, we found that coenzyme Q10 can improve exercise tolerance in patients with heart failure; however, in the investigation conducted by Madmani [30], this improvement was not statistically significant.…”

The Role of Coenzyme Q10 in Cardiovascular Disease Treatment: An Updated 2024 Systematic Review and Meta-Analysis of Prospective Cohort Studies (1990-2024)

“…The primary outcome, ejection fraction, showed a notable increase, indicating an enhancement in systolic performance. This finding aligns with previous studies suggesting that CoQ10 plays a crucial role in improving cardiac function by enhancing mitochondrial energy production and reducing oxidative stress [3,4,7,8,15].…”

“…Both fixed-effect and random-effects models provided similar effect sizes and confidence intervals, reinforcing the consistency of the results [3, 4, 7, 8, 11, 15].…”

“…Sensitivity analyses confirmed the robustness of these results, as excluding high-risk studies and using alternative statistical models did not significantly alter the outcomes [3, 4, 7, 8, 11, 15]. Publication bias was assessed and found to be low, further supporting the credibility of these findings [20, 21, 22, 23, 24].…”

“…The funnel plot, a scatter plot of effect sizes against their standard errors, was visually inspected for asymmetry. In this analysis, the funnel plot did not show significant asymmetry, suggesting a low risk of publication bias [20, 21, 22, 23, 24].…”