Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery

Abstract

(1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p = 0.01) and oxidative stress (p < 0.01), and significantly higher levels of antioxidant enzymes activities and inflammation after surgery (p < 0.05). The level of coenzyme Q10 was significantly positively correlated with antioxidant capacity (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative stress, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery.

The risks of ubiquinone and β-carotene deficiency and metabolic disorders in patients with oral cancer

“…The median level of ubiquinone was 280 nmol/L, which is lower than that of the healthy population (500-1700 nmol/L) [33]. Patients with cancer have been found to have a serious deficiency of ubiquinone [16,34,35]; in our previous clinical studies, we reported that patients with hepatocarcinoma had significantly lower ubiquinone concentration before or after surgery (before surgery: 320 nmol/L vs. after surgery: 280 nmol/L) [35]. Patients with oral cancer had lower ubiquinone concentration, which might be due to high oxidative stress [36].…”

Coenzyme q10 is potentially usedto improve lipid profile in diabetic hypercholesterolemia-induced periodontitis in the coastal area

“…Coenzyme Q10 can also increase the capacity of antioxidant and cellular energy metabolism in the skin [24]. At a dose of 300 mg/d, coenzyme Q10 supplementation significantly increased antioxidant capacity and reduced oxidative stress and inflammatory response in patients with hepatocellular carcinoma after surgery [25].…”

The Use of Antioxidants in the Treatment of Migraine

“…Coenzyme Q10, also known as ubiquinone, is an endogenously produced lipid compound, which contains 10 isoprenoid units in its molecule [71], and is lipid soluble [72]. It shows antioxidative properties and provides protection to cells against excessive ROS production, which prevents excessive oxidation of nucleic acids or lipid membrane peroxidation.…”

“…It shows antioxidative properties and provides protection to cells against excessive ROS production, which prevents excessive oxidation of nucleic acids or lipid membrane peroxidation. Apart from its antioxidative properties, coenzyme Q10 also shows some anti-inflammatory properties [72], is involved in pyrimidine synthesis (as cofactor), and, in turn, in DNA replication and RNA repair processes. Additionally, it is a modulatory factor of the physicochemical properties of cell membranes and gene expression [73,74].…”